1152 Top startups in San Diego for April 2025

We rank Cloudbeds, StockTwits and Lytx in San Diego along with 1149 other startups based on an algorithm that scores startups based on total investment, employee count, and quarterly website traffic. San Diego startup ecosystem ranks #24 globally and #9 in United States.

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Top Unicorn Startups in San Diego for 2025

Six startups have achieved unicorn status by exceeding USD 1 billion in valuation. Collectively, the top three unicorns in San Diego have raised more than USD 9.8B.
SB Score:760

ClickUp combines tasks, docs, spreadsheets, goal tracking, resources, and an inbox in one app for seamless organization. Streamline your workflow and stay productive with all your essential tools in one place.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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SB Score:641

Seismic provides software solutions for global sales and marketing teams, enabling them to streamline processes and drive revenue.

Industry:
Software & Data
Subindustry:
Software

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SB Score:552

Drata is an advanced security and compliance automation platform with the mission to help companies earn and keep the trust of their users, customers, partners, and prospects. Drata helps thousands of companies streamline their security compliance (SOC 2, ISO 27001, HIPAA, PCI DSS, GDPR, CCPA, CMMC, NIST CSF, etc.) through continuous, automated control monitoring and evidence collection, resulting in lower costs and time spent preparing for annual audits. Drata was founded in 2020 by Adam Markowitz, Daniel Marashlian, and Troy Markowitz and is based in San Diego, California, United States.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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Total amount:6

Best Startups in San Diego for 2025

SB Score:674

Cloudbeds offers a comprehensive software solution for hotels and accommodations to simplify operations, boost reservations, and elevate guest satisfaction.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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SB Score:652

StockTwits is a dynamic platform for investors and financial professionals to share real-time insights and information about stocks. With over 300,000 members and an audience of 40 million, users can research stocks, connect with others, and stay informed about market trends all in one place.

Industry:
Social & Leisure
Subindustry:
Social Media

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3rd

Lytx
SB Score:576

Lytx, Inc. develops video-based driver safety and fleet management solutions. The company offers DriveCam that identifies, prioritizes, and corrects the causes of poor driving to set standards for driver safety needs, RAIR web-based suite of compliance services that helps carriers manage CSA, hours-of-service, driver vehicle inspection report, and driver qualification aspects, a fleet tracking solution, and a fuel management solution. The company provides its solutions to trucking and transportation organizations, and their drivers, and the construction, distribution, government, transit, utility, waste and environmental, and commercial markets. It serves customers in the United States and internationally. The company was formerly known as DriveCam, Inc. and changed its name to Lytx, Inc. in November 2013. It was founded in 1998 and is based in San Diego, California.

Industry:
Social & Leisure
Subindustry:
Entertainment

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SB Score:575

Classy is a social enterprise that helps nonprofits maximize their impact through a suite of world-class online fundraising tools. The company also hosts the Collaborative and Classy Awards to recognize excellence in social innovation. Since 2011, they've powered tens of millions of donations from over 190 countries and raised over $2 billion for social good.

Industry:
Social & Leisure
Subindustry:
Entertainment

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SB Score:573

Equip Health offers a virtual eating disorder treatment program for families to recover at home. Their program is designed to provide support and guidance for those struggling with eating disorders, making it easier to access help and resources from the comfort of their own home.

Industry:
Healthtech
Subindustry:
Fitness

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SB Score:572

NetraDyne enhances fleet safety with advanced computer vision and data analysis, driving impactful improvements for businesses.

Industry:
Software & Data
Subindustry:
Data Analytics

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SB Score:567

Founded in 2015, Workiz is a SaaS CRM platform for small to medium-sized on-demand field service businesses, such as HVAC, Plumbing and Electrician businesses. With Workiz, field service pros can grow their business by ditching antiquated business management methods such as pen and paper, Excel spreadsheets and Google Calendar. Workiz provides an all-in0one platform which allows them to manage and streamline their operation and continuously grow. Clients report a 22% increase in revenue since starting to use the Workiz platform. Headquartered in San Diego, California, Workiz serves the North America field service markets, and was selected as both a ‘Facebook Playground’ partner and a ‘Google for Startup Accelerator’ partner.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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8th

GovX
SB Score:563

GovX is an eCommerce platform that honors and supports the US Military and First Responder communities. Shop exclusive discounts and products catered to those who serve our country.

Industry:
Ecommerce & Retail
Subindustry:
Ecommerce

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SB Score:561

Experience Cars & Bids, an online auction marketplace for modern enthusiast cars with daily auctions from the 1980s to the 2020s. Buy and sell your dream car with ease on this platform designed for car enthusiasts.

Industry:
Edtech
Subindustry:
Edutainment

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SB Score:560

SDG&E delivers dependable energy service to 3.4 million customers in San Diego and southern Orange counties, ensuring safety and reliability for all.

Industry:
Energy & Environment
Subindustry:
Energy

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SB Score:553

Trust & Will is simplifying estate planning and settlement with attorney-approved, legally valid documents and processes designed to adhere to individual state guidelines. Since 2017, we’ve helped hundreds of thousands of Trust & Will members leave their legacy with an affordable way to create an estate plan or settle the estate of a loved one. Our platform uses bank-level encryption that protects customer data and complies with the highest security standards, including SOC 2 and HIPAA. Trust & Will is the official estate planning benefit provider for AARP members, along with several leading financial institutions, who all believe in our mission of helping every family leave their legacy. To learn more, visit trustandwill.com. Trust & Will is an online service providing legal forms and information. Trust & Will is not a law firm and does not provide legal advice. Trust & Will was founded in 2017 and is headquartered in San Diego, CA.

Industry:
Fintech
Subindustry:
Financial Services

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Total amount:1152

Top 321 Healthtech Startups in San Diego for 2025

The top three Healthtech startups in San Diego have raised more than USD 2.68B. San Diego startup ecosystem ranks among the top 10 locations in the world for startups in Healthtech, holding the 5th position.
SB Score:573

Equip Health offers a virtual eating disorder treatment program for families to recover at home. Their program is designed to provide support and guidance for those struggling with eating disorders, making it easier to access help and resources from the comfort of their own home.

Industry:
Healthtech
Subindustry:
Fitness

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SB Score:524

Cortica specializes in diagnosing autism, ADHD, developmental delays, and other developmental differences. They provide a range of services, including in-home, in-clinic, and telehealth options, ensuring accessible and comprehensive support for individuals and families navigating these challenges.

Industry:
Healthtech
Subindustry:
Health Care

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SB Score:509

Element Biosciences develops advanced tools for genetic analysis, revolutionizing the field with cutting-edge technology. Their focus is on creating innovative solutions to empower researchers and clinicians in understanding and unlocking the secrets of the genome.

Industry:
Healthtech
Subindustry:
Biotechnology

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Total amount:321

Top 324 Software & Data Startups in San Diego for 2025

The top three Software & Data startups in San Diego have raised more than USD 1.32B. San Diego startup ecosystem ranks #20 globally for the Software & Data industry.
SB Score:674

Cloudbeds offers a comprehensive software solution for hotels and accommodations to simplify operations, boost reservations, and elevate guest satisfaction.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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SB Score:572

NetraDyne enhances fleet safety with advanced computer vision and data analysis, driving impactful improvements for businesses.

Industry:
Software & Data
Subindustry:
Data Analytics

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SB Score:567

Founded in 2015, Workiz is a SaaS CRM platform for small to medium-sized on-demand field service businesses, such as HVAC, Plumbing and Electrician businesses. With Workiz, field service pros can grow their business by ditching antiquated business management methods such as pen and paper, Excel spreadsheets and Google Calendar. Workiz provides an all-in0one platform which allows them to manage and streamline their operation and continuously grow. Clients report a 22% increase in revenue since starting to use the Workiz platform. Headquartered in San Diego, California, Workiz serves the North America field service markets, and was selected as both a ‘Facebook Playground’ partner and a ‘Google for Startup Accelerator’ partner.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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Total amount:324

Top 54 Marketing & Sales Startups in San Diego for 2025

The top three Marketing & Sales startups in San Diego have raised more than USD 344M. San Diego startup ecosystem ranks #12 globally for the Marketing & Sales industry.
SB Score:504

Revolutionize your marketing with Intelligence Driven Marketing Automation. Track, personalize, and automate customer journey communications seamlessly. Streamline your processes and engage customers like never before.

Industry:
Marketing & Sales
Subindustry:
Adtech

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SB Score:487

Lawmatics is a comprehensive CRM and marketing automation platform tailored for modern law firms. Streamline client intake, automate marketing, and manage the entire sales process in one place.

Industry:
Marketing & Sales
Subindustry:
CRM

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SB Score:471

Revolutionize customer experiences with a tailored touch. Offering personalized solutions, this startup creates unforgettable interactions. Perfect for businesses looking to stand out in a crowded market.

Industry:
Marketing & Sales
Subindustry:
CRM

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Total amount:54

Most Funded Startups in San Diego for 2025

The top three most funded startups in San Diego have raised total funding of more than USD 2.87B. Cue has 0.44% more funding than Genomatica.

1st

Cue
SB Score:498

Cue helps users track their health at the molecular level, revealing the interplay of activity, food, and sleep. Consumers can track five key health and lifestyle indicators: inflammation, vitamin D, fertility, influenza, and testosterone in just minutes, at home. The Cue sends the data via Bluetooth 4.0 to the user's smartphone, where the free Cue app reveals the interplay of activity, food, and sleep shaping the user at a molecular level.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:449

Genomatica creates eco-friendly chemicals from renewable sources, promoting sustainability in manufacturing.

Industry:
Energy & Environment
Subindustry:
Cleantech

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SB Score:425

Rakuten Medical is a biotechnology company that develops precision, cell-targeting investigational therapies based on its proprietary Alluminox platform comprising drugs, devices, and other related components.

Industry:
Healthtech
Subindustry:
Biotechnology

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Total amount:1152

Top Hiring Startups in San Diego by Employee Number

The top three hiring startups in San Diego have an median employee size that is between [5001-10000]
SB Score:163

Embassy of Things, located in vibrant San Diego, is spearheaded by experienced entrepreneurs specializing in industrial automation, machine learning, big data analytics, and IoT. Committed to innovation, they leverage their expertise to drive success and transform industries through cutting-edge technology solutions.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

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SDG&E delivers dependable energy service to 3.4 million customers in San Diego and southern Orange counties, ensuring safety and reliability for all.

Industry:
Energy & Environment
Subindustry:
Energy

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SB Score:419

Lumena Pharmaceuticals is developing oral therapeutics for rare liver diseases to improve liver function, relieve disease symptoms and dramatically impact patient health. The company’s clinical-stage product candidates carry a reduced risk of systemic toxicities by selectively targeting a transporter in the intestine and are designed to be minimally absorbed in the body. Lumena’s lead candidate, LUM001, has been extensively evaluated in other indications across 12 clinical studies in more than 1,400 subjects. Because of the extensive preclinical and clinical data package for a compound at this stage in development, LUM001 is positioned to rapidly progress through the clinic in pediatric and adult patients with several types of cholestatic liver disease. While Lumena’s primary focus is to develop novel treatments for patients with rare liver diseases, the company’s therapeutic approach also has promising potential in the treatment of metabolic diseases affecting the liver, a significant and growing health problem in children and adults.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:524

Cortica specializes in diagnosing autism, ADHD, developmental delays, and other developmental differences. They provide a range of services, including in-home, in-clinic, and telehealth options, ensuring accessible and comprehensive support for individuals and families navigating these challenges.

Industry:
Healthtech
Subindustry:
Health Care

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Total amount:1152

Explore the Startup Ecosystem of San Diego

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Top Cities for Startups in United States - Ranked by StartupBlink

StartupBlink ranks the startup ecosystems of more than 100 countries and 1,000 cities. Download our latest Global Startup Ecosystem Report.
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2024 National Rank CityGlobal Rank
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Total Score

Access subscores for 1000 cities and 100 countries

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Quantity Score
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Quality Score
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Business Score
1st
0
1st
0
710.966
00.00
00.00
00.00
2nd
0
2nd
0
251.377
00.00
00.00
00.00
3rd
0
4th
0
121.937
00.00
00.00
00.00
4th
0
5th
0
109.679
00.00
00.00
00.00
5th
0
12th
0
52.052
00.00
00.00
00.00
6th
0
15th
0
42.256
00.00
00.00
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1
17th
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4
41.259
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00.00
00.00
8th
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1
19th
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1
37.971
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00.00
00.00
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0
24th
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2
34.098
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00.00
00.00
10th
0
25th
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1
33.768
00.00
00.00
00.00
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