Top Unicorn Startups in San Diego for 2025

In San Diego, we rank 6 unicorn startups based on an algorithm that considers factors such as total investment, quarterly employee count, and website traffic. Unicorns in San Diego are falling behind the performance of their global counterparts.

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Top Unicorn Startups in San Diego for 2025

SB Score:800

ClickUp combines tasks, docs, spreadsheets, goal tracking, resources, and an inbox in one app for seamless organization. Streamline your workflow and stay productive with all your essential tools in one place.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

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Regional Rank (North America)

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Global Rank (WorldWide)

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SB Score:624

Seismic provides software solutions for global sales and marketing teams, enabling them to streamline processes and drive revenue.

Industry:
Software & Data
Subindustry:
Software

National Rank (United States)

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Regional Rank (North America)

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Global Rank (WorldWide)

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SB Score:581

Drata automates compliance and security workflows for companies, streamlining control monitoring. With Drata, businesses can effortlessly manage security controls, ensuring they meet regulatory requirements with ease.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

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Regional Rank (North America)

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Global Rank (WorldWide)

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Total amount:6

Best Healthtech Startups in San Diego for 2025

San Diego startups in the Healthtech industry are overperforming their global industry peers. The top three Healthtech unicorns in San Diego have raised more than USD 1.58B, an amount that is higher than the global industry average.
SB Score:503

Biosplice Therapeutics specializes in developing advanced treatments for tissue regeneration at the cellular level. Our cutting-edge research focuses on restoring damaged tissues to improve overall health and well-being.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

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Regional Rank (North America)

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Global Rank (WorldWide)

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Total amount:1

Most Valuable Unicorns in San Diego for 2025

The top three most valuable unicorns in San Diego have raised total funding of more than USD 198M. Among the top three funded unicorns, the most popular industry, based on total funding, is Software & Data.
SB Score:800

ClickUp combines tasks, docs, spreadsheets, goal tracking, resources, and an inbox in one app for seamless organization. Streamline your workflow and stay productive with all your essential tools in one place.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:624

Seismic provides software solutions for global sales and marketing teams, enabling them to streamline processes and drive revenue.

Industry:
Software & Data
Subindustry:
Software

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:571

Shield AI utilizes advanced artificial intelligence to safeguard both service members and civilians. Their mission is to provide protection through intelligent systems, ensuring safety and security in high-risk situations.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:581

Drata automates compliance and security workflows for companies, streamlining control monitoring. With Drata, businesses can effortlessly manage security controls, ensuring they meet regulatory requirements with ease.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:503

Biosplice Therapeutics specializes in developing advanced treatments for tissue regeneration at the cellular level. Our cutting-edge research focuses on restoring damaged tissues to improve overall health and well-being.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:569

Tealium's Customer Data Hub seamlessly integrates all your data sources, including mobile, web, and offline, with multiple vendor platforms for a comprehensive view of customer insights.

Industry:
Software & Data
Subindustry:
Software

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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Total amount:6

Top Hiring Unicorns in San Diego by Employee Number

The top three hiring unicorns in San Diego have an average employee size that is smaller than to the global average. Among these, the Software & Data industry features the unicorn with the largest workforce.
SB Score:800

ClickUp combines tasks, docs, spreadsheets, goal tracking, resources, and an inbox in one app for seamless organization. Streamline your workflow and stay productive with all your essential tools in one place.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:581

Drata automates compliance and security workflows for companies, streamlining control monitoring. With Drata, businesses can effortlessly manage security controls, ensuring they meet regulatory requirements with ease.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:571

Shield AI utilizes advanced artificial intelligence to safeguard both service members and civilians. Their mission is to provide protection through intelligent systems, ensuring safety and security in high-risk situations.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:569

Tealium's Customer Data Hub seamlessly integrates all your data sources, including mobile, web, and offline, with multiple vendor platforms for a comprehensive view of customer insights.

Industry:
Software & Data
Subindustry:
Software

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

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View full page

Total amount:6

Explore the Startup Ecosystem of San Diego

National Rank

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9th

0

Regional Rank

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10th

1

Global Rank

(WorldWide)

24th

2

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Top Cities for Startups in United States - Ranked by StartupBlink
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2024 National Rank CityGlobal RankTotal Score

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Quantity Score
Quality ScoreBusiness Score
1st
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1st
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710.966
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2nd
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2nd
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251.377
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3rd
0
4th
0
121.937
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00.00
00.00
4th
0
5th
0
109.679
00.00
00.00
00.00
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