Top Unicorn Startups in San Diego for 2025

In San Diego, we rank 6 unicorn startups based on an algorithm that considers factors such as total investment, quarterly employee count, and website traffic. Unicorns in San Diego are falling behind the performance of their global counterparts.

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Top Unicorn Startups in San Diego for 2025

SB Score:760

ClickUp combines tasks, docs, spreadsheets, goal tracking, resources, and an inbox in one app for seamless organization. Streamline your workflow and stay productive with all your essential tools in one place.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

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Regional Rank (North America)

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Global Rank (WorldWide)

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SB Score:641

Seismic provides software solutions for global sales and marketing teams, enabling them to streamline processes and drive revenue.

Industry:
Software & Data
Subindustry:
Software

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SB Score:552

Drata is an advanced security and compliance automation platform with the mission to help companies earn and keep the trust of their users, customers, partners, and prospects. Drata helps thousands of companies streamline their security compliance (SOC 2, ISO 27001, HIPAA, PCI DSS, GDPR, CCPA, CMMC, NIST CSF, etc.) through continuous, automated control monitoring and evidence collection, resulting in lower costs and time spent preparing for annual audits. Drata was founded in 2020 by Adam Markowitz, Daniel Marashlian, and Troy Markowitz and is based in San Diego, California, United States.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

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Regional Rank (North America)

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Global Rank (WorldWide)

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Total amount:6

Best Healthtech Startups in San Diego for 2025

San Diego startups in the Healthtech industry are overperforming their global industry peers. The top three Healthtech unicorns in San Diego have raised more than USD 2.68B, an amount that is higher than the global industry average.
SB Score:398

Biosplice Therapeutics specializes in developing advanced treatments for tissue regeneration at the cellular level. Our cutting-edge research focuses on restoring damaged tissues to improve overall health and well-being.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

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Regional Rank (North America)

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Global Rank (WorldWide)

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Total amount:1

Most Valuable Unicorns in San Diego for 2025

The top three most valuable unicorns in San Diego have raised total funding of more than USD 198M. Among the top three funded unicorns, the most popular industry, based on total funding, is Software & Data.
SB Score:760

ClickUp combines tasks, docs, spreadsheets, goal tracking, resources, and an inbox in one app for seamless organization. Streamline your workflow and stay productive with all your essential tools in one place.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

0

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Regional Rank (North America)

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Global Rank (WorldWide)

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SB Score:641

Seismic provides software solutions for global sales and marketing teams, enabling them to streamline processes and drive revenue.

Industry:
Software & Data
Subindustry:
Software

National Rank (United States)

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Regional Rank (North America)

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Global Rank (WorldWide)

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SB Score:540

Shield AI utilizes advanced artificial intelligence to safeguard both service members and civilians. Their mission is to provide protection through intelligent systems, ensuring safety and security in high-risk situations.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

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Total amount:6

Top Hiring Unicorns in San Diego by Employee Number

The top three hiring unicorns in San Diego have an average employee size that is smaller than to the global average. Among these, the Software & Data industry features the unicorn with the largest workforce.
SB Score:641

Seismic provides software solutions for global sales and marketing teams, enabling them to streamline processes and drive revenue.

Industry:
Software & Data
Subindustry:
Software

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:760

ClickUp combines tasks, docs, spreadsheets, goal tracking, resources, and an inbox in one app for seamless organization. Streamline your workflow and stay productive with all your essential tools in one place.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:552

Drata is an advanced security and compliance automation platform with the mission to help companies earn and keep the trust of their users, customers, partners, and prospects. Drata helps thousands of companies streamline their security compliance (SOC 2, ISO 27001, HIPAA, PCI DSS, GDPR, CCPA, CMMC, NIST CSF, etc.) through continuous, automated control monitoring and evidence collection, resulting in lower costs and time spent preparing for annual audits. Drata was founded in 2020 by Adam Markowitz, Daniel Marashlian, and Troy Markowitz and is based in San Diego, California, United States.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:540

Shield AI utilizes advanced artificial intelligence to safeguard both service members and civilians. Their mission is to provide protection through intelligent systems, ensuring safety and security in high-risk situations.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page

Total amount:6

Explore the Startup Ecosystem of San Diego

National Rank

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Regional Rank

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10th

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Global Rank

(WorldWide)

24th

2

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Top Cities for Startups in United States - Ranked by StartupBlink

StartupBlink ranks the startup ecosystems of more than 100 countries and 1,000 cities. Download our latest Global Startup Ecosystem Report.
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2024 National Rank CityGlobal Rank
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Total Score

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Quantity Score
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Quality Score
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Business Score
1st
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1st
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710.966
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00.00
2nd
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2nd
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251.377
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00.00
00.00
3rd
0
4th
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121.937
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00.00
00.00
4th
0
5th
0
109.679
00.00
00.00
00.00
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