Top Startup Exits in San Diego for 2025

In San Diego, we rank 15 startup exits based on an algorithm that considers factors such as total investment, quarterly employee count, and website traffic. Startup exits in San Diego are falling behind the performance of their global counterparts.

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Top Startup Exits in San Diego for 2025

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Qpex Biopharma develops a pipeline of agents addressing critical needs for the treatment of infectious diseases. It develops multiple antibiotic drugs intended to combat antimicrobial resistance.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

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VelosBio is an operator of a clinical-stage biopharmaceutical company intended to develop novel, first-in-class, ROR1-directed therapeutics to transform the lives of patients with cancer. The company's ROR1-directed therapeutics is a cell-surface protein that is expressed on many hematologic and solid tumors but is absent from normal tissues, making it an attractive tumor-specific therapeutic target and has demonstrated positive preclinical results in tumor models, enabling institutions to get novel targeted therapies for use as monotherapy or in combination across a broad range of cancers. It was founded in 2017 and headquartered in San Diego, California.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

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Total amount:15

Best Healthtech Startup Exits in San Diego for 2025

San Diego exits in the Healthtech industry are overperforming their global industry peers. The top three Healthtech exits in San Diego have raised more than USD 2.68B, an amount that is higher than the global industry average.
Unranked

Qpex Biopharma develops a pipeline of agents addressing critical needs for the treatment of infectious diseases. It develops multiple antibiotic drugs intended to combat antimicrobial resistance.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

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VelosBio is an operator of a clinical-stage biopharmaceutical company intended to develop novel, first-in-class, ROR1-directed therapeutics to transform the lives of patients with cancer. The company's ROR1-directed therapeutics is a cell-surface protein that is expressed on many hematologic and solid tumors but is absent from normal tissues, making it an attractive tumor-specific therapeutic target and has demonstrated positive preclinical results in tumor models, enabling institutions to get novel targeted therapies for use as monotherapy or in combination across a broad range of cancers. It was founded in 2017 and headquartered in San Diego, California.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

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Regional Rank (North America)

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Global Rank (WorldWide)

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Unranked

DTx Pharma develops technology that will unleash RNA-based therapeutics as the modality of choice for personalized treatment across therapeutic areas. DTx Pharma believes its approach to delivering RNA medicines solves some of the issues that limited previous-generation platforms, including poor pharmacokinetics and insufficient cellular uptake.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

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Regional Rank (North America)

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Global Rank (WorldWide)

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Total amount:13

Largest Startup Exits in San Diego by Funding

The top three largest startup exits in San Diego have raised total funding of more than USD 116M. Among the top three funded exits, the most popular industry, based on total funding, is Healthtech.
Unranked

TuSimple is a self-driving truck company developing a technology that allows driving from depot to depot without human intervention. The company's trucks are capable of self-driving from depot to depot and do so every day for its customers. It develops a commercial-ready Level 4 (SAE) fully autonomous driving solution for the logistics industry. The company is driven by a mission to increase safety, decrease transportation costs, and reduce carbon emissions. In 2015, Jianan Hao, Mo Chen, and Xiaodi Hou headquartered the company in San Diego, California.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

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Unranked

Receptos is a privately-held drug discovery and development company which utilizes pioneering G protein-coupled receptor (GPCR) technology to facilitate information-driven drug design for developing best- and first-in-class drugs.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

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Unranked

BioLegend is a biotechnology firm that offers immunological reagents for biomedical research.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

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Regional Rank (North America)

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Global Rank (WorldWide)

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Total amount:15

Top Hiring Startup Exits in San Diego by Employee Size

The top three hiring startup exits in San Diego have an average employee size that is smaller than to the global average. Among these, the Healthtech industry features the startup exit with the largest workforce.
Unranked

Receptos is a privately-held drug discovery and development company which utilizes pioneering G protein-coupled receptor (GPCR) technology to facilitate information-driven drug design for developing best- and first-in-class drugs.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

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Regional Rank (North America)

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Global Rank (WorldWide)

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Unranked

BioLegend is a biotechnology firm that offers immunological reagents for biomedical research.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

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Regional Rank (North America)

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Global Rank (WorldWide)

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Vividion is a biotechnology company focused on developing innovative therapeutics that treat major unmet clinical needs using the first platform for proteome-wide drug and target discovery.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

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Regional Rank (North America)

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Global Rank (WorldWide)

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Total amount:15

Explore the Startup Ecosystem of San Diego

National Rank

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Regional Rank

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10th

1

Global Rank

(WorldWide)

24th

2

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Top Cities for Startups in United States - Ranked by StartupBlink

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2024 National Rank CityGlobal Rank
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Total Score

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Quantity Score
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Quality Score
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Business Score
1st
0
1st
0
710.966
00.00
00.00
00.00
2nd
0
2nd
0
251.377
00.00
00.00
00.00
3rd
0
4th
0
121.937
00.00
00.00
00.00
4th
0
5th
0
109.679
00.00
00.00
00.00
5th
0
12th
0
52.052
00.00
00.00
00.00
6th
0
15th
0
42.256
00.00
00.00
00.00
7th
+
1
17th
+
4
41.259
00.00
00.00
00.00
8th
-
1
19th
-
1
37.971
00.00
00.00
00.00
9th
0
24th
-
2
34.098
00.00
00.00
00.00
10th
0
25th
+
1
33.768
00.00
00.00
00.00
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