385 Top startups in San Mateo for April 2025

We rank PingPong, GoPro and Yellow.ai in San Mateo along with 382 other startups based on an algorithm that scores startups based on total investment, employee count, and quarterly website traffic. San Mateo is part of San Francisco Bay startup ecosystem which ranks #1 globally and #1 in North America.

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Top Unicorn Startups in San Mateo for 2025

Nine startups have achieved unicorn status by exceeding USD 1 billion in valuation. Collectively, the top three unicorns in San Mateo have raised more than USD 13.7B.
SB Score:661

Verkada's user-friendly software platform, Command, simplifies camera and site management across all devices. Effortlessly monitor and control cameras with intuitive features for seamless operation.

Industry:
Software & Data
Subindustry:
Education-Other

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SB Score:606

Evidation measures health in everyday life and enables anyone to participate in groundbreaking research and health programs. Built upon a foundation of user privacy and control over permissioned health data, Evidation's Achievement platform is trusted by millions of individuals—generating data with unprecedented speed, scale, and rigor. We partner with leading healthcare companies to understand health and disease outside the clinic walls. Guided by our mission to enable and empower everyone to participate in better health outcomes, Evidation is working to bring people individualized, proactive, and accessible healthcare—faster. Founded in 2012, Evidation Heath is headquartered in California. We collaborate as a distributed team with additional offices around the globe. To learn more, visit evidation.com, or follow us on Twitter @evidation

Industry:
Software & Data
Subindustry:
Apps

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SB Score:600

Neo4j is the leading graph data platform, empowering organizations like Comcast, ICIJ, NASA, UBS, and Volvo Cars to harness real-world context in their data for solving challenges of all sizes.

Industry:
Software & Data
Subindustry:
Data Analytics

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Total amount:9

Best Startups in San Mateo for 2025

SB Score:646

Revolutionizing global eCommerce, this unique Fintech startup is dedicated to empowering marketplace sellers worldwide. Their focus on international markets sets them apart, making them the go-to choice for sellers looking to streamline their financial transactions and grow their businesses on a global scale.

Industry:
Fintech
Subindustry:
Financial Services

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SB Score:629

GoPro is an activity image capture company. It is a brand of personal cameras used in extreme action video photography. GoPro produces HD HERO, a line of wearable and gear-mountable cameras and accessories, making it easy for people to capture and share their lives' most exciting moments in high definition. GoPro's products are sold through specialty retailers in more than 50 countries and online. Founded in 2002 by Nicholas Woodman, GoPro is headquartered in San Mateo, California, United States.

Industry:
Hardware & IoT
Subindustry:
Consumer Electronics

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SB Score:605

Yellow.ai is a conversational AI platform, enabling enterprises to unlock business potential at scale. The platform is trusted across 85+ countries by 1000+ enterprises, including Domino’s, Sephora, Hyundai, MG Motors, Biogen International, Edelweiss Broking, Siemens Limited, Food Panda, Zalora, Zenyum, JD.ID, Carrefour, Kuwait Food Company (Americana), Choithrams, Amouage Oman, Arabian Radio Network, Bharat Petroleum, Waste Connections US and Tata. Powered by Dynamic AI agents for enterprises, the company aims to deliver human-like interactions that boost customer satisfaction and increase employee engagement at scale, through its no-code/low-code platform. Recognised by Frost & Sullivan, Forrester, Gartner, IDC, and G2 as a leader, the company has raised more than $102M from blue-chip investors and has offices across six countries.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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SB Score:593

Galxe is the leading Web3 credential data network in the world. A collaborative credential infrastructure enabling brands and developers to engage communities and build robust products in Web3. (Previously known as Project Galaxy)

Industry:
Software & Data
Subindustry:
Enterprise Technology

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SB Score:573

OneSignal is a customer messaging and engagement platform that allows businesses to provide a seamless messaging experience to create meaningful customer connections. OneSignal's multi-channel platform enables businesses to deliver over 8 billion messages daily. OneSignal is designed to scale with businesses and deliver messages more quickly. The platform leverages machine learning to send communications at the optimal time by creating personalized messages and sending them to the right audiences by comparing performance, enabling clients to deliver engaging mobile and web push messages across all platforms.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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SB Score:559

Alpaca creates a modern financial service platform catering to tech-savvy users. Their startup offers a seamless and innovative approach to managing finances for the new generation, providing a user-friendly experience.

Industry:
Fintech
Subindustry:
Fintech-Other

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SB Score:554

Helix integrates genomics data into clinical care, advancing research and personalized health solutions.

Industry:
Software & Data
Subindustry:
Data Analytics

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SB Score:548

Cyence offers a groundbreaking platform that calculates cyber risks in probabilities and dollars, revolutionizing how businesses assess and manage their cybersecurity strategies.

Industry:
Hardware & IoT
Subindustry:
Hardware

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SB Score:545

Engageli is a user-friendly digital learning platform that promotes inclusivity. It provides an engaging online environment for all learners.

Industry:
Edtech
Subindustry:
Edtech

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SB Score:535

Workona provides a cloud-based work management platform that empowers users to efficiently access and manage resources. With features like customizable workspace tabs, tab management, tab suspension, and document templates, it streamlines workflows and enhances productivity for individuals and teams alike.

Industry:
Software & Data
Subindustry:
SaaS

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SB Score:526

Photomath utilizes AI and a smartphone to provide step-by-step explanations for math problems, covering topics from basic arithmetic to advanced calculus. Users can easily understand and learn math concepts through interactive instructions.

Industry:
Edtech
Subindustry:
Edtech

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Total amount:385

Top 201 Software & Data Startups in San Mateo for 2025

The top three Software & Data startups in San Mateo have raised more than USD 1.81B. San Mateo is part of San Francisco Bay startup ecosystem which ranks #1 globally for the Software & Data industry.
SB Score:605

Yellow.ai is a conversational AI platform, enabling enterprises to unlock business potential at scale. The platform is trusted across 85+ countries by 1000+ enterprises, including Domino’s, Sephora, Hyundai, MG Motors, Biogen International, Edelweiss Broking, Siemens Limited, Food Panda, Zalora, Zenyum, JD.ID, Carrefour, Kuwait Food Company (Americana), Choithrams, Amouage Oman, Arabian Radio Network, Bharat Petroleum, Waste Connections US and Tata. Powered by Dynamic AI agents for enterprises, the company aims to deliver human-like interactions that boost customer satisfaction and increase employee engagement at scale, through its no-code/low-code platform. Recognised by Frost & Sullivan, Forrester, Gartner, IDC, and G2 as a leader, the company has raised more than $102M from blue-chip investors and has offices across six countries.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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SB Score:593

Galxe is the leading Web3 credential data network in the world. A collaborative credential infrastructure enabling brands and developers to engage communities and build robust products in Web3. (Previously known as Project Galaxy)

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

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SB Score:573

OneSignal is a customer messaging and engagement platform that allows businesses to provide a seamless messaging experience to create meaningful customer connections. OneSignal's multi-channel platform enables businesses to deliver over 8 billion messages daily. OneSignal is designed to scale with businesses and deliver messages more quickly. The platform leverages machine learning to send communications at the optimal time by creating personalized messages and sending them to the right audiences by comparing performance, enabling clients to deliver engaging mobile and web push messages across all platforms.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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Total amount:201

Top 33 Fintech Startups in San Mateo for 2025

The top three Fintech startups in San Mateo have raised more than USD 777M. San Mateo is part of San Francisco Bay startup ecosystem which ranks #1 globally for the Fintech industry.
SB Score:646

Revolutionizing global eCommerce, this unique Fintech startup is dedicated to empowering marketplace sellers worldwide. Their focus on international markets sets them apart, making them the go-to choice for sellers looking to streamline their financial transactions and grow their businesses on a global scale.

Industry:
Fintech
Subindustry:
Financial Services

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SB Score:559

Alpaca creates a modern financial service platform catering to tech-savvy users. Their startup offers a seamless and innovative approach to managing finances for the new generation, providing a user-friendly experience.

Industry:
Fintech
Subindustry:
Fintech-Other

National Rank (United States)

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3rd

Step
SB Score:516

Step is a financial services company that builds mobile-based banking for teenagers. It helps teens and young adults achieve financial independence and knowledge at an earlier age. The company's mission is to create a bank that gives its users the tools to become smarter with their money and reward them along their financial journey. It was founded in 2018 and headquartered in Palo Alto, California.

Industry:
Fintech
Subindustry:
Financial Services

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Total amount:33

Top 33 Healthtech Startups in San Mateo for 2025

The top three Healthtech startups in San Mateo have raised more than USD 795M. San Mateo is part of San Francisco Bay startup ecosystem which ranks #1 globally for the Healthtech industry.
SB Score:440

Human API is a real-time health data network that gives consumers a simple way to view and share their health data from everywhere - regardless of how or where that data was collected, processed, or stored. The company provides a single, secure connection to data from 90% of US hospitals, electronic medical records, pharmacies, and labs, along with 300+ wearable devices and wellness apps. Consumers are in full control of what companies they share their health data with, and companies have one easy way to access fragmented health data sources. It was founded in 2013 and is based in San Mateo, California.

Industry:
Healthtech
Subindustry:
Health Care

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2nd

Bold
SB Score:425

Bold is a digital fitness program tailored for older adults, empowering them to achieve their strongest, happiest, and healthiest lives from the comfort of home. By offering engaging workouts and wellness resources, Bold supports users in enhancing their overall well-being and vitality.

Industry:
Healthtech
Subindustry:
Health Care

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SB Score:394

MORE Health connects users to top physicians globally through its online medical collaboration platform, providing unparalleled access to expert healthcare.

Industry:
Healthtech
Subindustry:
Health Care

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Total amount:33

Most Funded Startups in San Mateo for 2025

The top three most funded startups in San Mateo have raised total funding of more than USD 2.42B. Veev has 0.42% more funding than Cyera.

1st

Veev
SB Score:484

Veev is a building technology company that reinvents the way homes are built and experienced. Veev's home operating system creates room-specific lighting, shade, and climate control and also offers protection against intrusion and cybercrime, thereby providing clients a one-stop solution to all their smart housing requirements. Key components of the Veev panelized building system include the use of light gauge steel (LGS) for framing, high performance acrylic (HPA) for surfaces and millwork, radiant climate control systems, and a digital home ecosystem. The company is focused currently on high-performance multifamily and accessory dwelling unit (ADU) products. The current development pipeline totals more than 230 units and 620,000 gross building square feet.

Industry:
Hardware & IoT
Subindustry:
Consumer Electronics

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SB Score:443

Cyera offers cloud data security solutions for organizations, providing a clear picture of data reality. Founded in 2021 and based in San Mateo, USA, Cyera helps companies protect their data with confidence.

Industry:
Software & Data
Subindustry:
Cloud

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SB Score:455

Observe offers performance management tools powered by a flexible observability platform. Unlock actionable insights for optimizing your operations and driving business success in real time.

Industry:
Software & Data
Subindustry:
Data Analytics

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Total amount:385

Top Hiring Startups in San Mateo by Employee Number

The top three hiring startups in San Mateo have an median employee size that is between [1001-5000]
SB Score:646

Revolutionizing global eCommerce, this unique Fintech startup is dedicated to empowering marketplace sellers worldwide. Their focus on international markets sets them apart, making them the go-to choice for sellers looking to streamline their financial transactions and grow their businesses on a global scale.

Industry:
Fintech
Subindustry:
Financial Services

National Rank (United States)

0

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Regional Rank (North America)

0

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SB Score:548

Cyence offers a groundbreaking platform that calculates cyber risks in probabilities and dollars, revolutionizing how businesses assess and manage their cybersecurity strategies.

Industry:
Hardware & IoT
Subindustry:
Hardware

National Rank (United States)

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SB Score:451

Apttus enterprise-class software drives the vital business process between the buyer’s interest in a purchase and the realization of revenue. Delivered on the world’s most trusted and comprehensive cloud platform, the Salesforce Platform, Apttus’ Quote-to-Cash solutions increase sales and maximize visibility and control. Applications include Configure-Price-Quote (CPQ), Contract Management, Renewals and Revenue Management. Additionally, Apttus’ patent pending X-Author technology enables Microsoft Office to be a user-interface with full interaction and control between Salesforce and Microsoft Office. Apttus is based in San Mateo, California, with additional offices in London, UK and Ahmedabad, India.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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Total amount:385

Explore the Startup Ecosystem of San Mateo

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Top Cities for Startups in United States - Ranked by StartupBlink

StartupBlink ranks the startup ecosystems of more than 100 countries and 1,000 cities. Download our latest Global Startup Ecosystem Report.
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2024 National Rank CityGlobal Rank
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Total Score

Access subscores for 1000 cities and 100 countries

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Quantity Score
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Quality Score
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Business Score
1st
0
1st
0
710.966
00.00
00.00
00.00
2nd
0
2nd
0
251.377
00.00
00.00
00.00
3rd
0
4th
0
121.937
00.00
00.00
00.00
4th
0
5th
0
109.679
00.00
00.00
00.00
5th
0
12th
0
52.052
00.00
00.00
00.00
6th
0
15th
0
42.256
00.00
00.00
00.00
7th
+
1
17th
+
4
41.259
00.00
00.00
00.00
8th
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1
19th
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1
37.971
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00.00
00.00
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0
24th
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2
34.098
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00.00
00.00
10th
0
25th
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1
33.768
00.00
00.00
00.00
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