29 Top startups in Worcester for January 2025

We rank Leal Therapeutics, Vella Bioscience and Stability Health in Worcester along with 26 other startups based on an algorithm that scores startups based on total investment, employee count, and quarterly website traffic. Worcester ranks #454 globally and #134 in United States.

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Best Startups in Worcester for 2025

SB Score:365

Leal Therapeutics pioneers innovative treatments for patients, focusing on developing groundbreaking therapeutics that address unmet medical needs. Their mission is to enhance patient outcomes through cutting-edge research and a commitment to improving health and well-being.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

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Regional Rank (North America)

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SB Score:337

Vella Bioscience is a health-tech company focused on empowering women through sexual wellness. By providing innovative solutions and resources, it enhances women's understanding and experiences, fostering confidence and autonomy in their sexual health journey.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

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SB Score:323

HelixBind, a biotech company in Massachusetts, specializes in innovative technologies. They create cutting-edge solutions for the healthcare industry, focusing on improving diagnostics and treatments.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:305

OpenCity is a dynamic Live Chat Platform designed for restaurants and nightclubs. Engage with customers in real-time, boost customer service, and streamline communication. Join OpenCity to revolutionize your venue's online presence.

Industry:
Social & Leisure
Subindustry:
Entertainment

National Rank (United States)

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SB Score:304

Blustream connects companies with customers by using product usage data for better post-sale engagement.

Industry:
Software & Data
Subindustry:
Data Analytics

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SB Score:283

ComputerVault, accessible at www.ComputerVault.com, partners with TD SYNNEX and Arrow Electronics to provide cutting-edge software solutions. Positioned as the exclusive alternative to VMware and Citrix, ComputerVault offers a robust on-premises private cloud that enhances efficiency and performance for businesses seeking reliable virtualization options.

Industry:
Software & Data
Subindustry:
Software

National Rank (United States)

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Regional Rank (North America)

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SB Score:262

Revolutionize trucking management with our AI-powered web platform. Simplify on-the-go operations and optimize efficiency with cutting-edge technology. Experience the future of trucking business management at your fingertips.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

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SB Score:249

EnerConnex, led by experts with 20+ years in deregulated energy markets, simplifies access to electricity and natural gas options.

Industry:
Energy & Environment
Subindustry:
Energy

National Rank (United States)

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Regional Rank (North America)

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MassHire Central Region Workforce Board is a collaborative effort catering to a variety of employers and job seekers. Their mission is to connect individuals with job opportunities and support businesses in finding the right talent.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

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SB Score:240

Juniper Biomedical is a pioneering medical device company specializing in implantable neuromodulation technology. It develops a micro-implant that provides targeted treatment for various pelvic health conditions, enhancing patient outcomes through precision and innovation in neuromodulation.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

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Regional Rank (North America)

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Total amount:29

Top 9 Software & Data Startups in Worcester for 2025

The top three Software & Data startups in Worcester have raised more than USD 25M. Worcester ranks #365 globally for the Software & Data industry.
SB Score:304

Blustream connects companies with customers by using product usage data for better post-sale engagement.

Industry:
Software & Data
Subindustry:
Data Analytics

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:283

ComputerVault, accessible at www.ComputerVault.com, partners with TD SYNNEX and Arrow Electronics to provide cutting-edge software solutions. Positioned as the exclusive alternative to VMware and Citrix, ComputerVault offers a robust on-premises private cloud that enhances efficiency and performance for businesses seeking reliable virtualization options.

Industry:
Software & Data
Subindustry:
Software

National Rank (United States)

0

View

Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:262

Revolutionize trucking management with our AI-powered web platform. Simplify on-the-go operations and optimize efficiency with cutting-edge technology. Experience the future of trucking business management at your fingertips.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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Total amount:9

Top 11 Healthtech Startups in Worcester for 2025

The top three Healthtech startups in Worcester have raised more than USD 73.8M. Worcester ranks #251 globally for the Healthtech industry.
SB Score:365

Leal Therapeutics pioneers innovative treatments for patients, focusing on developing groundbreaking therapeutics that address unmet medical needs. Their mission is to enhance patient outcomes through cutting-edge research and a commitment to improving health and well-being.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:337

Vella Bioscience is a health-tech company focused on empowering women through sexual wellness. By providing innovative solutions and resources, it enhances women's understanding and experiences, fostering confidence and autonomy in their sexual health journey.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

0

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Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

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Total amount:11

Top 3 Social & Leisure Startups in Worcester for 2025

The top three Social & Leisure startups in Worcester have raised more than USD 17.1M. Worcester ranks among the top 10 locations in the world for startups in Social & Leisure, holding the 3rd position.
SB Score:305

OpenCity is a dynamic Live Chat Platform designed for restaurants and nightclubs. Engage with customers in real-time, boost customer service, and streamline communication. Join OpenCity to revolutionize your venue's online presence.

Industry:
Social & Leisure
Subindustry:
Entertainment

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

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SB Score:223

Creative Hub Worcester provides inclusive and affordable artistic programs for all. It offers a welcoming space for creative expression, ensuring everyone has the opportunity to participate and showcase their talents.

Industry:
Social & Leisure
Subindustry:
Arts

National Rank (United States)

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Regional Rank (North America)

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SB Score:30

Zephyr Workshop creates and publishes tabletop games with a focus on compact size and immersive storytelling. Their games are designed to bring joy through innovative mechanics and premium components, inviting players to explore new worlds and experience unforgettable adventures.

Industry:
Social & Leisure
Subindustry:
Gaming

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

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Total amount:3

Most Funded Startups in Worcester for 2025

The top three most funded startups in Worcester have raised total funding of more than USD 81.2M. Leal Therapeutics has 0.72% more funding than Helixbind.
SB Score:365

Leal Therapeutics pioneers innovative treatments for patients, focusing on developing groundbreaking therapeutics that address unmet medical needs. Their mission is to enhance patient outcomes through cutting-edge research and a commitment to improving health and well-being.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:323

HelixBind, a biotech company in Massachusetts, specializes in innovative technologies. They create cutting-edge solutions for the healthcare industry, focusing on improving diagnostics and treatments.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:304

Blustream connects companies with customers by using product usage data for better post-sale engagement.

Industry:
Software & Data
Subindustry:
Data Analytics

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page

Total amount:29

Top Hiring Startups in Worcester by Employee Number

The top three hiring startups in Worcester have an median employee size that is between [11-50]
SB Score:283

ComputerVault, accessible at www.ComputerVault.com, partners with TD SYNNEX and Arrow Electronics to provide cutting-edge software solutions. Positioned as the exclusive alternative to VMware and Citrix, ComputerVault offers a robust on-premises private cloud that enhances efficiency and performance for businesses seeking reliable virtualization options.

Industry:
Software & Data
Subindustry:
Software

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:365

Leal Therapeutics pioneers innovative treatments for patients, focusing on developing groundbreaking therapeutics that address unmet medical needs. Their mission is to enhance patient outcomes through cutting-edge research and a commitment to improving health and well-being.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:323

HelixBind, a biotech company in Massachusetts, specializes in innovative technologies. They create cutting-edge solutions for the healthcare industry, focusing on improving diagnostics and treatments.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page

Total amount:29

Explore the Startup Ecosystem of Worcester

National Rank

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134th

24

Regional Rank

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152nd

26

Global Rank

(WorldWide)

454th

77

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251.377
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121.937
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109.679
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