32 Top startups in Watertown for January 2025

We rank Athenahealth, Neumora Therapeutics and Affini-T Therapeutics in Watertown along with 29 other startups based on an algorithm that scores startups based on total investment, employee count, and quarterly website traffic. Watertown is part of Boston Area which ranks #5 globally and #4 in North America.

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Best Startups in Watertown for 2025

SB Score:786

Athenahealth offers cloud-based business and clinical services for physician practices, including practice management, electronic health record software, payer knowledge-base, and back-office operations. Their web-native solutions streamline healthcare workflows for more efficient and effective patient care.

Industry:
Healthtech
Subindustry:
Health Care

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SB Score:492

Affini-T Therapeutics is a biotechnology company focused on developing innovative T-cell therapies for cancer patients. Utilizing a proven platform, it identifies high-affinity T cell receptors targeting oncogenic mutations, paving the way for advanced treatments for solid tumors.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:443

Tome Biosciences is a pioneering biotechnology company that specializes in programmable gene insertion technology. Utilizing advanced CRISPR techniques, it enables precise insertion of any genetic sequence, regardless of size or location, into any genome, unlocking new possibilities for genetic research and therapeutic applications.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:438

Lyndra Therapeutics revolutionizes medicine with a cutting-edge technology platform for a healthier future. Their innovative approach reinvents drug delivery, creating a more effective and convenient experience for patients.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:415

Zus Health empowers healthcare innovators to develop technologies and services unhindered by traditional obstacles, fostering a new era of healthcare solutions.

Industry:
Healthtech
Subindustry:
Health Care

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SB Score:413

Prolific Works offers an online publishing platform for authors to share and promote their work easily. Join a community of writers and readers to discover new stories and connect with fellow book lovers.

Industry:
Marketing & Sales
Subindustry:
Adtech

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SB Score:401

Seismic Therapeutics is a biotechnology company leveraging machine learning throughout the biologics discovery process to expedite the development of immunology drugs. By integrating advanced technology, it aims to enhance efficiency and innovation in creating effective therapeutic solutions.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:398

Entact Bio is a biotech startup focused on developing medications to enhance protein function. With expertise in DUB biochemistry, chemical biology, and drug development, the team is advancing innovative therapies in the preclinical stage.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:390

Theraplant is a licensed producer of medical marijuana, providing high-quality products for patients seeking natural relief. Their focus is on creating accessible and effective solutions for those in need of alternative medicine options.

Industry:
Foodtech
Subindustry:
Agtech

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SB Score:371

The ExSpiron device, cleared by FDA and CE Mark, measures minute ventilation non-invasively. It provides a clear understanding of breathing patterns, making it easier to monitor respiratory motion.

Industry:
Healthtech
Subindustry:
Biotechnology

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Total amount:32

Top 22 Healthtech Startups in Watertown for 2025

The top three Healthtech startups in Watertown have raised more than USD 1.15B. Watertown is part of Boston Area which ranks #2 globally for the Healthtech industry.
SB Score:786

Athenahealth offers cloud-based business and clinical services for physician practices, including practice management, electronic health record software, payer knowledge-base, and back-office operations. Their web-native solutions streamline healthcare workflows for more efficient and effective patient care.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

0

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Regional Rank (North America)

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Global Rank (WorldWide)

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SB Score:492

Affini-T Therapeutics is a biotechnology company focused on developing innovative T-cell therapies for cancer patients. Utilizing a proven platform, it identifies high-affinity T cell receptors targeting oncogenic mutations, paving the way for advanced treatments for solid tumors.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

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Regional Rank (North America)

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Total amount:22

Top 5 Software & Data Startups in Watertown for 2025

The top three Software & Data startups in Watertown have raised more than USD 26.7M. Watertown is part of Boston Area which ranks #5 globally for the Software & Data industry.
SB Score:279

Monotony.ai operates in Stealth mode, leveraging technology to revolutionize industries. Its innovative solutions are reshaping traditional processes behind the scenes.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

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An AI-powered Pest Identification platform connects users with service providers quickly and efficiently, simplifying the process of addressing pest problems.

Industry:
Software & Data
Subindustry:
Software

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SB Score:42

Multitude Insights empowers law enforcement agencies to harness the power of unstructured data. Founded in 2021 and based in Watertown, Massachusetts, the company equips agencies with innovative tools to analyze and utilize valuable information, enhancing their operational capabilities and decision-making processes.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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Total amount:5

Top 1 Ecommerce & Retail Startups in Watertown for 2025

Watertown is part of Boston Area which ranks #11 globally for the Ecommerce & Retail industry.

Total amount:1

Most Funded Startups in Watertown for 2025

The top three most funded startups in Watertown have raised total funding of more than USD 1.15B. Neumora Therapeutics has 1.16% more funding than Lyndra Therapeutics.
SB Score:438

Lyndra Therapeutics revolutionizes medicine with a cutting-edge technology platform for a healthier future. Their innovative approach reinvents drug delivery, creating a more effective and convenient experience for patients.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

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Regional Rank (North America)

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SB Score:401

Seismic Therapeutics is a biotechnology company leveraging machine learning throughout the biologics discovery process to expedite the development of immunology drugs. By integrating advanced technology, it aims to enhance efficiency and innovation in creating effective therapeutic solutions.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

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Total amount:32

Top Hiring Startups in Watertown by Employee Number

The top three hiring startups in Watertown have an median employee size that is between [101-250]
SB Score:786

Athenahealth offers cloud-based business and clinical services for physician practices, including practice management, electronic health record software, payer knowledge-base, and back-office operations. Their web-native solutions streamline healthcare workflows for more efficient and effective patient care.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:492

Affini-T Therapeutics is a biotechnology company focused on developing innovative T-cell therapies for cancer patients. Utilizing a proven platform, it identifies high-affinity T cell receptors targeting oncogenic mutations, paving the way for advanced treatments for solid tumors.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:443

Tome Biosciences is a pioneering biotechnology company that specializes in programmable gene insertion technology. Utilizing advanced CRISPR techniques, it enables precise insertion of any genetic sequence, regardless of size or location, into any genome, unlocking new possibilities for genetic research and therapeutic applications.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page

Total amount:32

Explore the Startup Ecosystem of Watertown

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251.377
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121.937
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109.679
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