88 Top startups in Waltham for January 2025

We rank Fresenius Medical Care West Scranton, Alignable and LumiraDx in Waltham along with 85 other startups based on an algorithm that scores startups based on total investment, employee count, and quarterly website traffic. Waltham is part of Boston Area which ranks #5 globally and #4 in North America.

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Top Unicorn Startups in Waltham for 2025

Two startups have achieved unicorn status by exceeding USD 1 billion in valuation. Collectively, the top two unicorns in Waltham have raised more than USD 13.9B.
SB Score:707

Devoted Health provides personalized healthcare plans for seniors, offering dedicated guides and cutting-edge technology.

Industry:
Healthtech
Subindustry:
Health Care

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SB Score:457

BostonGene is a leading biomedical software company specializing in cutting-edge solutions for personalized cancer treatment. Their innovative technology enables healthcare providers to tailor therapies to individual patients, improving outcomes and transforming the future of cancer care.

Industry:
Healthtech
Subindustry:
Health Care

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Total amount:2

Best Startups in Waltham for 2025

SB Score:548

Alignable empowers local businesses to network, market, and support their communities. It provides a platform for businesses to grow together, shifting power back to the local level.

Industry:
Software & Data
Subindustry:
SaaS

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SB Score:521

LumiraDx empowers users to improve healthcare, social care, and financial outcomes at a reasonable cost. With LumiraDx, achieving better health and financial stability is more accessible and efficient.

Industry:
Healthtech
Subindustry:
Health Care

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SB Score:506

CallMiner offers AI-driven speech and customer interaction analysis. Enhance customer service and boost efficiency with their cutting-edge technology.

Industry:
Software & Data
Subindustry:
Data Analytics

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SB Score:503

connectRN is a tech platform that enhances clinicians' lives by offering a supportive community, networking opportunities, and access to resources.

Industry:
Healthtech
Subindustry:
Health Care

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SB Score:499

Eleanor Health offers accessible mental health and substance use disorder treatment through clinics, virtual platforms, and in-home services. Receive comprehensive care from qualified professionals to support your journey to wellness.

Industry:
Healthtech
Subindustry:
Health Care

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SB Score:492

InterWell Health, a partnership between Fresenius Medical Care North America, is a physician-focused healthcare initiative. Offering nationwide services, it aims to enhance the healthcare experience through collaboration and innovation.

Industry:
Healthtech
Subindustry:
Health Care

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SB Score:478

PaymentWorks is a secure platform helping businesses prevent B2B payment fraud and stay compliant. Mitigate risk and ensure regulatory adherence with ease.

Industry:
Software & Data
Subindustry:
Cybersecurity

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SB Score:466

6 River Systems is revolutionizing e-commerce and retail fulfillment automation. Founded in 2015 by industry veterans, the Boston-based company aims to redefine warehouse operations.

Industry:
Ecommerce & Retail
Subindustry:
Retail

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10th

Uptycs
SB Score:466

Uptycs is a cutting-edge security analytics platform that harnesses the power of osquery for scalability. It empowers users with advanced tools to enhance their security measures effectively and efficiently.

Industry:
Hardware & IoT
Subindustry:
Hardware

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SB Score:455

Vecna Robotics provides innovative solutions for automating material handling, optimizing workflows, and streamlining fulfillment processes. Their technologies seamlessly integrate into existing operations to increase efficiency and productivity.

Industry:
Transportation
Subindustry:
Logistics

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Total amount:88

Top 38 Healthtech Startups in Waltham for 2025

The top three Healthtech startups in Waltham have raised more than USD 953M. Waltham is part of Boston Area which ranks #2 globally for the Healthtech industry.
SB Score:521

LumiraDx empowers users to improve healthcare, social care, and financial outcomes at a reasonable cost. With LumiraDx, achieving better health and financial stability is more accessible and efficient.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

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SB Score:503

connectRN is a tech platform that enhances clinicians' lives by offering a supportive community, networking opportunities, and access to resources.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

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Total amount:38

Top 21 Software & Data Startups in Waltham for 2025

The top three Software & Data startups in Waltham have raised more than USD 283M. Waltham is part of Boston Area which ranks #5 globally for the Software & Data industry.
SB Score:548

Alignable empowers local businesses to network, market, and support their communities. It provides a platform for businesses to grow together, shifting power back to the local level.

Industry:
Software & Data
Subindustry:
SaaS

National Rank (United States)

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SB Score:506

CallMiner offers AI-driven speech and customer interaction analysis. Enhance customer service and boost efficiency with their cutting-edge technology.

Industry:
Software & Data
Subindustry:
Data Analytics

National Rank (United States)

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SB Score:478

PaymentWorks is a secure platform helping businesses prevent B2B payment fraud and stay compliant. Mitigate risk and ensure regulatory adherence with ease.

Industry:
Software & Data
Subindustry:
Cybersecurity

National Rank (United States)

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Total amount:21

Top 5 Ecommerce & Retail Startups in Waltham for 2025

The top three Ecommerce & Retail startups in Waltham have raised more than USD 212M. Waltham is part of Boston Area which ranks #11 globally for the Ecommerce & Retail industry.
SB Score:466

6 River Systems is revolutionizing e-commerce and retail fulfillment automation. Founded in 2015 by industry veterans, the Boston-based company aims to redefine warehouse operations.

Industry:
Ecommerce & Retail
Subindustry:
Retail

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SB Score:397

TakeOff empowers grocers with an automated software platform for e-Commerce success. Boost your online presence and streamline operations with our innovative solution.

Industry:
Ecommerce & Retail
Subindustry:
Ecommerce

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SB Score:339

SeQure DX offers secure data exchange services for non-commercial sites. Simplifying data sharing with advanced encryption technology, SeQure DX ensures confidentiality and integrity for all your digital information.

Industry:
Ecommerce & Retail
Subindustry:
Ecommerce & Retail-Other

National Rank (United States)

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Total amount:5

Most Funded Startups in Waltham for 2025

The top three most funded startups in Waltham have raised total funding of more than USD 953M. Upstream Bio has 0.28% more funding than Zenas BioPharma.
SB Score:445

Upstream Bio is dedicated to advancing innovative antibody therapies for the treatment of severe asthma, aiming to improve patients' quality of life. By targeting underlying mechanisms of the disease, the company strives to provide effective solutions for those suffering from this challenging condition.

Industry:
Healthtech
Subindustry:
Health Care

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SB Score:436

Zenas BioPharma is a Florida-based biopharmaceutical company dedicated to creating innovative immune-based therapies for patients. By harnessing the power of the immune system, Zenas aims to develop effective treatments that enhance patient outcomes and improve quality of life.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

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Total amount:88

Top Hiring Startups in Waltham by Employee Number

The top three hiring startups in Waltham have an median employee size that is between [1001-5000]
SB Score:521

LumiraDx empowers users to improve healthcare, social care, and financial outcomes at a reasonable cost. With LumiraDx, achieving better health and financial stability is more accessible and efficient.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
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SB Score:492

InterWell Health, a partnership between Fresenius Medical Care North America, is a physician-focused healthcare initiative. Offering nationwide services, it aims to enhance the healthcare experience through collaboration and innovation.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:506

CallMiner offers AI-driven speech and customer interaction analysis. Enhance customer service and boost efficiency with their cutting-edge technology.

Industry:
Software & Data
Subindustry:
Data Analytics

National Rank (United States)

0

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Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
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Total amount:88

Explore the Startup Ecosystem of Waltham

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Top Cities for Startups in United States - Ranked by StartupBlink
StartupBlink ranks the startup ecosystems of more than 100 countries and 1,000 cities. Download our latest Global Startup Ecosystem Report.
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2024 National Rank CityGlobal RankTotal Score

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Quantity Score
Quality ScoreBusiness Score
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1st
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710.966
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251.377
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3rd
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121.937
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4th
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5th
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109.679
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