282 Top startups in St. Louis for April 2025

We rank Lumeris, Adalo and Clever Real Estate in St. Louis along with 279 other startups based on an algorithm that scores startups based on total investment, employee count, and quarterly website traffic. St. Louis startup ecosystem ranks #115 globally and #40 in United States.

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Best Startups in St. Louis for 2025

SB Score:521

Lumeris is an innovative company transforming accountable care delivery. They provide cutting-edge solutions to improve healthcare outcomes and lower costs.

Industry:
Healthtech
Subindustry:
Health Care

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SB Score:490

Adalo is a tech company focused on Android, software, and IT. Specializing in creating innovative solutions, they offer cutting-edge products for businesses and individuals. With a passion for technology, Adalo strives to make complex systems accessible and user-friendly for all.

Industry:
Software & Data
Subindustry:
Software

National Rank (United States)

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SB Score:475

Clever Real Estate is a company that specializes in the fields of commercial real estate and online marketplaces. It offers a software platform that guides its users through the process of interviewing real estate agents to find the right one for them. The company was founded in 2017 and is headquartered in St Louis, Missouri.

Industry:
Ecommerce & Retail
Subindustry:
Ecommerce

National Rank (United States)

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SB Score:438

Surround Care is dedicated to enhancing healthcare by improving affordability, quality, access, and the overall patient experience for everyone. Their innovative solutions aim to make healthcare more accessible and effective, ensuring that all individuals receive the care they deserve.

Industry:
Healthtech
Subindustry:
Health Care

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SB Score:436

Playbite is a vibrant social gaming platform that enables users to connect, play, earn rewards, and compete in exciting games. Founded by Diego Kafie, Stu Feldt, and Nic Weber, Playbite fosters a dynamic community where gaming meets social interaction.

Industry:
Edtech
Subindustry:
Edtech

National Rank (United States)

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Regional Rank (North America)

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SB Score:431

Travel in style and comfort with wardrobe essentials that are perfect for both the journey and the destination. Our collection of clothing and accessories ensures you look and feel your best no matter where you go.

Industry:
Ecommerce & Retail
Subindustry:
Ecommerce

National Rank (United States)

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SB Score:424

Capacity is an AI-powered helpdesk that streamlines customer and employee support through automation. Enhance efficiency and satisfaction with this innovative solution.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

National Rank (United States)

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Regional Rank (North America)

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SB Score:417

Wugen is creating ready-to-use cellular therapies for treating solid tumors and blood cancers.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

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Regional Rank (North America)

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SB Score:416

Balto enhances contact center performance by providing real-time guidance to boost conversions, improve customer experience, and reduce ramp time.

Industry:
Software & Data
Subindustry:
Data Analytics

National Rank (United States)

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SB Score:415

Native Pet offers organic, highly effective supplements for dogs and cats. With limited ingredients, their products provide optimal nutrition for pets.

Industry:
Foodtech
Subindustry:
Food and Beverage

National Rank (United States)

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Regional Rank (North America)

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SB Score:412

Tunespeak lets users discover and share music, videos, and photos with friends in a fun and interactive online platform.

Industry:
Social & Leisure
Subindustry:
Entertainment

National Rank (United States)

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Regional Rank (North America)

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Total amount:282

Top 52 Healthtech Startups in St. Louis for 2025

The top three Healthtech startups in St. Louis have raised more than USD 1.42B. St. Louis startup ecosystem ranks #50 globally for the Healthtech industry.
SB Score:521

Lumeris is an innovative company transforming accountable care delivery. They provide cutting-edge solutions to improve healthcare outcomes and lower costs.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

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Regional Rank (North America)

0

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Global Rank (WorldWide)

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SB Score:438

Surround Care is dedicated to enhancing healthcare by improving affordability, quality, access, and the overall patient experience for everyone. Their innovative solutions aim to make healthcare more accessible and effective, ensuring that all individuals receive the care they deserve.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

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SB Score:417

Wugen is creating ready-to-use cellular therapies for treating solid tumors and blood cancers.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

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Total amount:52

Top 74 Software & Data Startups in St. Louis for 2025

The top three Software & Data startups in St. Louis have raised more than USD 192M. St. Louis startup ecosystem ranks #133 globally for the Software & Data industry.
SB Score:490

Adalo is a tech company focused on Android, software, and IT. Specializing in creating innovative solutions, they offer cutting-edge products for businesses and individuals. With a passion for technology, Adalo strives to make complex systems accessible and user-friendly for all.

Industry:
Software & Data
Subindustry:
Software

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:424

Capacity is an AI-powered helpdesk that streamlines customer and employee support through automation. Enhance efficiency and satisfaction with this innovative solution.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:416

Balto enhances contact center performance by providing real-time guidance to boost conversions, improve customer experience, and reduce ramp time.

Industry:
Software & Data
Subindustry:
Data Analytics

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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Total amount:74

Top 33 Ecommerce & Retail Startups in St. Louis for 2025

The top three Ecommerce & Retail startups in St. Louis have raised more than USD 45.3M. St. Louis startup ecosystem ranks #140 globally for the Ecommerce & Retail industry.
SB Score:475

Clever Real Estate is a company that specializes in the fields of commercial real estate and online marketplaces. It offers a software platform that guides its users through the process of interviewing real estate agents to find the right one for them. The company was founded in 2017 and is headquartered in St Louis, Missouri.

Industry:
Ecommerce & Retail
Subindustry:
Ecommerce

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:431

Travel in style and comfort with wardrobe essentials that are perfect for both the journey and the destination. Our collection of clothing and accessories ensures you look and feel your best no matter where you go.

Industry:
Ecommerce & Retail
Subindustry:
Ecommerce

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:410

Customily empowers customers to easily personalize products online. With our user-friendly e-commerce platform, users can create unique items by adding their personal touch. Say goodbye to cookie-cutter products and hello to customized goods tailored just for you.

Industry:
Ecommerce & Retail
Subindustry:
Ecommerce

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

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Total amount:33

Most Funded Startups in St. Louis for 2025

The top three most funded startups in St. Louis have raised total funding of more than USD 1.42B. Lumeris has 0.08% more funding than Surround Care.
SB Score:521

Lumeris is an innovative company transforming accountable care delivery. They provide cutting-edge solutions to improve healthcare outcomes and lower costs.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:438

Surround Care is dedicated to enhancing healthcare by improving affordability, quality, access, and the overall patient experience for everyone. Their innovative solutions aim to make healthcare more accessible and effective, ensuring that all individuals receive the care they deserve.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:355

MediBeacon offers clinicians essential optical diagnostics to enhance patient care. Their innovative technology provides critical information for improved medical decision-making.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

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Total amount:282

Top Hiring Startups in St. Louis by Employee Number

The top three hiring startups in St. Louis have an median employee size that is between [1001-5000]
SB Score:521

Lumeris is an innovative company transforming accountable care delivery. They provide cutting-edge solutions to improve healthcare outcomes and lower costs.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

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SB Score:438

Surround Care is dedicated to enhancing healthcare by improving affordability, quality, access, and the overall patient experience for everyone. Their innovative solutions aim to make healthcare more accessible and effective, ensuring that all individuals receive the care they deserve.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:346

EmpowerMe enhances senior living communities by offering top-notch, integrated on-site therapy, diagnostics, and primary care services. By providing comprehensive health solutions, it ensures residents receive the support they need, fostering a healthier and more vibrant living environment.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

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Total amount:282

Explore the Startup Ecosystem of St. Louis

National Rank

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Regional Rank

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46th

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Global Rank

(WorldWide)

115th

3

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Top Cities for Startups in United States - Ranked by StartupBlink

StartupBlink ranks the startup ecosystems of more than 100 countries and 1,000 cities. Download our latest Global Startup Ecosystem Report.
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2024 National Rank CityGlobal Rank
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Total Score

Access subscores for 1000 cities and 100 countries

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Quantity Score
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Quality Score
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Business Score
1st
0
1st
0
710.966
00.00
00.00
00.00
2nd
0
2nd
0
251.377
00.00
00.00
00.00
3rd
0
4th
0
121.937
00.00
00.00
00.00
4th
0
5th
0
109.679
00.00
00.00
00.00
5th
0
12th
0
52.052
00.00
00.00
00.00
6th
0
15th
0
42.256
00.00
00.00
00.00
7th
+
1
17th
+
4
41.259
00.00
00.00
00.00
8th
-
1
19th
-
1
37.971
00.00
00.00
00.00
9th
0
24th
-
2
34.098
00.00
00.00
00.00
10th
0
25th
+
1
33.768
00.00
00.00
00.00
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