97 Top startups in South San Francisco for April 2025

We rank Freenome, Plenty and Birst in South San Francisco along with 94 other startups based on an algorithm that scores startups based on total investment, employee count, and quarterly website traffic. South San Francisco is part of San Francisco Bay startup ecosystem which ranks #1 globally and #1 in North America.

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Best Startups in South San Francisco for 2025

SB Score:536

Freenome is a biotech company developing accurate, accessible, and non-invasive disease screening products for proactively treating cancer and other diseases at their most manageable stages. The company is developing a simple blood test to detect early-stage cancer and make treatments more effective and provides a platform that helps design healthy conditions for an individual based on his/her cell-free genome. The company aims to reinvent disease management through systematized early detection and intervention.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:534

Plenty is a vertical farming company delivering fresh, pesticide-free produce to customers. Get your hands on high-quality greens without harmful chemicals.

Industry:
Foodtech
Subindustry:
Agtech

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SB Score:519

Birst empowers users to easily create and use analytical applications without needing specialized skills. By automating complex tasks, this platform simplifies the process for regular individuals, making business intelligence more accessible and efficient.

Industry:
Software & Data
Subindustry:
SaaS

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SB Score:514

Insitro uses machine learning and biology to revolutionize drug discovery. Their innovative approach transforms the process, making it more efficient and effective.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:477

Carrum Health is a platform connecting individuals with scheduled medical procedures. Access top-tier healthcare providers at competitive prices. Experience hassle-free coordination and payment for your treatment.

Industry:
Healthtech
Subindustry:
Health Care

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SB Score:470

Veracyte is a global genomic diagnostics company that improves patient care by providing answers to clinical questions, informing diagnosis and treatment decisions throughout the patient journey in cancer and other diseases. The company’s growing menu of genomic tests leverage advances in genomic science and technology, enabling patients to avoid risky, costly diagnostic procedures and quicken time to appropriate treatment. The company’s tests in thyroid cancer, lung cancer, breast cancer, and idiopathic pulmonary fibrosis are available to patients, and its lymphoma subtyping test is in development. With Veracyte’s exclusive global license to a best-in-class diagnostics instrument platform, the company is positioned to deliver its tests to patients worldwide.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:468

Sutro Biopharma is a clinical stage drug discovery, development, and manufacturing company. It is mainly engaged in the development of biopharmaceutical products. The company manufactures next-generation protein therapeutics for cancer and autoimmune disorders through its proprietary integrated cell-free protein synthesis platform, XpressCF. Products offered by the company include STRO-001 for patients with multiple myeloma and non-Hodgkin lymphoma and STRO-002 for the treatment of ovarian and endometrial cancers.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:467

ArsenalBio is building a programmable cell therapy company to create highly effective and accessible immune cell therapies to impact outcomes for a much broader number of patients, initially those with cancer. Founded in 2019, ArsenalBio is focused on integrating technologies such as CRISPR-based genome engineering, scaled and high throughput target identification, synthetic biology, and machine learning to advance a new paradigm to discover and develop immune cell therapies. With its programmable and computationally driven approach, ArsenalBio aspires to evolve critical metrics of success for immune cell therapies, including enhanced and broader efficacy, increased patient safety, reduced provider costs and expanded market access.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:456

Genome Medical is a national telegenomics technology, services, and strategy company bringing genomic medicine to everyday care. Through its nationwide network of genetic specialists and an efficient Genome Care DeliveryTM technology platform, we provide expert virtual genetic care for individuals and their families to improve health and well-being. They also help health care providers and their patients navigate the rapidly expanding field of genetics and utilize test results to understand the risk for disease, accelerate disease diagnosis, make informed treatment decisions and lower the cost of care. The company was founded in 2016 and is based in South San Francisco, California, United States.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:448

Cellares revolutionizes cell therapy manufacturing, streamlining processes for optimal efficiency. Their innovative technology enhances production capabilities, leading the way in the advancement of regenerative medicine.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:447

Bright Pattern offers cutting-edge multichannel cloud contact center software, empowering businesses to efficiently engage with customers.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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Regional Rank (North America)

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Total amount:97

Top 11 Software & Data Startups in South San Francisco for 2025

The top three Software & Data startups in South San Francisco have raised more than USD 521M. South San Francisco is part of San Francisco Bay startup ecosystem which ranks #1 globally for the Software & Data industry.
SB Score:519

Birst empowers users to easily create and use analytical applications without needing specialized skills. By automating complex tasks, this platform simplifies the process for regular individuals, making business intelligence more accessible and efficient.

Industry:
Software & Data
Subindustry:
SaaS

National Rank (United States)

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Regional Rank (North America)

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Global Rank (WorldWide)

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SB Score:447

Bright Pattern offers cutting-edge multichannel cloud contact center software, empowering businesses to efficiently engage with customers.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

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Regional Rank (North America)

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Total amount:11

Top 2 Fintech Startups in South San Francisco for 2025

The top three Fintech startups in South San Francisco have raised more than USD 13.9M. South San Francisco is part of San Francisco Bay startup ecosystem which ranks #1 globally for the Fintech industry.
SB Score:278

Dama Financial offers financial services for businesses in restricted industries. Simplifying banking solutions, Dama provides safe and compliant transactions for industries such as cannabis and hemp.

Industry:
Fintech
Subindustry:
Online Banking

National Rank (United States)

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Regional Rank (North America)

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SB Score:204

Coinroll is a Delaware C corporation creating coinroll.app, a fintech platform for institutional investors. The platform streamlines digital investments, offering real-time insights on new opportunities.

Industry:
Fintech
Subindustry:
Cryptocurrency

National Rank (United States)

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Regional Rank (North America)

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Global Rank (WorldWide)

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Total amount:2

Top 65 Healthtech Startups in South San Francisco for 2025

The top three Healthtech startups in South San Francisco have raised more than USD 3.82B. South San Francisco is part of San Francisco Bay startup ecosystem which ranks #1 globally for the Healthtech industry.
SB Score:536

Freenome is a biotech company developing accurate, accessible, and non-invasive disease screening products for proactively treating cancer and other diseases at their most manageable stages. The company is developing a simple blood test to detect early-stage cancer and make treatments more effective and provides a platform that helps design healthy conditions for an individual based on his/her cell-free genome. The company aims to reinvent disease management through systematized early detection and intervention.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:514

Insitro uses machine learning and biology to revolutionize drug discovery. Their innovative approach transforms the process, making it more efficient and effective.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:477

Carrum Health is a platform connecting individuals with scheduled medical procedures. Access top-tier healthcare providers at competitive prices. Experience hassle-free coordination and payment for your treatment.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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Total amount:65

Most Funded Startups in South San Francisco for 2025

The top three most funded startups in South San Francisco have raised total funding of more than USD 5.27B. Freenome has 0.18% more funding than Plenty.
SB Score:536

Freenome is a biotech company developing accurate, accessible, and non-invasive disease screening products for proactively treating cancer and other diseases at their most manageable stages. The company is developing a simple blood test to detect early-stage cancer and make treatments more effective and provides a platform that helps design healthy conditions for an individual based on his/her cell-free genome. The company aims to reinvent disease management through systematized early detection and intervention.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:534

Plenty is a vertical farming company delivering fresh, pesticide-free produce to customers. Get your hands on high-quality greens without harmful chemicals.

Industry:
Foodtech
Subindustry:
Agtech

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:514

Insitro uses machine learning and biology to revolutionize drug discovery. Their innovative approach transforms the process, making it more efficient and effective.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page

Total amount:97

Top Hiring Startups in South San Francisco by Employee Number

The top three hiring startups in South San Francisco have an median employee size that is between [501-1000]
SB Score:536

Freenome is a biotech company developing accurate, accessible, and non-invasive disease screening products for proactively treating cancer and other diseases at their most manageable stages. The company is developing a simple blood test to detect early-stage cancer and make treatments more effective and provides a platform that helps design healthy conditions for an individual based on his/her cell-free genome. The company aims to reinvent disease management through systematized early detection and intervention.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:470

Veracyte is a global genomic diagnostics company that improves patient care by providing answers to clinical questions, informing diagnosis and treatment decisions throughout the patient journey in cancer and other diseases. The company’s growing menu of genomic tests leverage advances in genomic science and technology, enabling patients to avoid risky, costly diagnostic procedures and quicken time to appropriate treatment. The company’s tests in thyroid cancer, lung cancer, breast cancer, and idiopathic pulmonary fibrosis are available to patients, and its lymphoma subtyping test is in development. With Veracyte’s exclusive global license to a best-in-class diagnostics instrument platform, the company is positioned to deliver its tests to patients worldwide.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:534

Plenty is a vertical farming company delivering fresh, pesticide-free produce to customers. Get your hands on high-quality greens without harmful chemicals.

Industry:
Foodtech
Subindustry:
Agtech

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:519

Birst empowers users to easily create and use analytical applications without needing specialized skills. By automating complex tasks, this platform simplifies the process for regular individuals, making business intelligence more accessible and efficient.

Industry:
Software & Data
Subindustry:
SaaS

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page

Total amount:97

Explore the Startup Ecosystem of South San Francisco

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Top Cities for Startups in United States - Ranked by StartupBlink

StartupBlink ranks the startup ecosystems of more than 100 countries and 1,000 cities. Download our latest Global Startup Ecosystem Report.
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2024 National Rank CityGlobal Rank
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Quality Score
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Business Score
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710.966
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251.377
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121.937
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109.679
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