15 Top startups in Sioux Falls for January 2025

We rank Prismatic, C-Suite Network and RENEW Energy in Sioux Falls along with 12 other startups based on an algorithm that scores startups based on total investment, employee count, and quarterly website traffic. Sioux Falls ranks #506 globally and #147 in United States.

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Best Startups in Sioux Falls for 2025

SB Score:431

Accelerate integration development and provide a seamless marketplace experience for customers. Designed to meet developers' needs, quickly build and deliver native integrations.

Industry:
Ecommerce & Retail
Subindustry:
Ecommerce & Retail-Other

National Rank (United States)

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SB Score:334

Connecting top C-suite leaders worldwide, this trusted network provides a platform for collaboration and growth. Join the world's most respected community of executives for unparalleled networking opportunities and valuable insights.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

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SB Score:297

RENEW Energy is a dynamic company specializing in asset management services for renewable energy projects. They empower clients to efficiently manage their investments in sustainable energy, ensuring optimal performance and environmental benefits.

Industry:
Energy & Environment
Subindustry:
Energy

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SB Score:290

Bridge Medicines is a cutting-edge drug discovery company. They specialize in developing innovative medicines to address unmet medical needs.

Industry:
Healthtech
Subindustry:
Pharmaceuticals

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SB Score:241

Bluepeak facilitates connectivity and accessibility through infrastructure investments, resource provision, and information dissemination, ultimately bringing people together.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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Advanced Remote Sensing, based in Sioux Falls, South Dakota, offers cutting-edge satellite imagery services for various industries. Founded in 2018, the company provides high-quality data for informed decision-making.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

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SB Score:186

BlueDop Medical is an innovative vascular expert software based in Sioux Falls, South Dakota. It provides healthcare providers with valuable insights and actionable data for better patient care.

Industry:
Healthtech
Subindustry:
Health Care

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SB Score:154

Four Percent is a rapidly growing community for modern entrepreneurs, offering top-notch education, tools, resources, and a supportive network to help them excel in their ventures. Join us to become a successful digital entrepreneur and reach your full potential.

Industry:
Marketing & Sales
Subindustry:
Digital Marketing

National Rank (United States)

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11th

Dromo
SB Score:113

Dromo streamlines the spreadsheet import process with an AI-driven solution that automatically matches Excel columns, reducing onboarding friction. This innovative tool empowers users with flexible options for data cleaning and validation, making data management more efficient and user-friendly.

Industry:
Software & Data
Subindustry:
Software

National Rank (United States)

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Total amount:15

Top 5 Software & Data Startups in Sioux Falls for 2025

The top three Software & Data startups in Sioux Falls have raised more than USD 1.28M. Sioux Falls ranks #505 globally for the Software & Data industry.
SB Score:334

Connecting top C-suite leaders worldwide, this trusted network provides a platform for collaboration and growth. Join the world's most respected community of executives for unparalleled networking opportunities and valuable insights.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:241

Bluepeak facilitates connectivity and accessibility through infrastructure investments, resource provision, and information dissemination, ultimately bringing people together.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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Advanced Remote Sensing, based in Sioux Falls, South Dakota, offers cutting-edge satellite imagery services for various industries. Founded in 2018, the company provides high-quality data for informed decision-making.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

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Total amount:5

Top 2 Fintech Startups in Sioux Falls for 2025

Sioux Falls ranks among the top 10 locations in the world for startups in Fintech, holding the 2nd position.
SB Score:92

CoinLion is a digital currency exchange and portfolio management platform that empowers users to navigate the complexities of digital assets. By incentivizing information sharing, it simplifies asset management and rewards participation, creating an engaging community focused on enhancing the digital investment experience.

Industry:
Fintech
Subindustry:
Blockchain

National Rank (United States)

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SB Score:29

InsuranceLibrary.com is the go-to platform for insurance questions, connecting consumers with licensed agents for expert answers. With over 15,000 responses, the site helps thousands daily, providing clarity and guidance on insurance matters.

Industry:
Fintech
Subindustry:
Personal Finance

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

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Total amount:2

Top 2 Edtech Startups in Sioux Falls for 2025

Sioux Falls ranks among the top 10 locations in the world for startups in Edtech, holding the 3rd position.
SB Score:90

Sandbox is a digital technology community offering seminars, instructional videos, and tool recommendations for businesses. Dive into online resources to better understand and leverage digital tools.

Industry:
Edtech
Subindustry:
Edtech

National Rank (United States)

0

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Regional Rank (North America)

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Global Rank (WorldWide)

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LCB Academy is a tech camp for kids in grades K-12. Students learn programming, science, math, and engineering while doing what they love. Dive into a fun, educational experience at LCB and discover the world of technology!

Industry:
Edtech
Subindustry:
Edtech

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

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Total amount:2

Most Funded Startups in Sioux Falls for 2025

The top three most funded startups in Sioux Falls have raised total funding of more than USD 45.5M. Prismatic has 2.42% more funding than Bridge Medicines.
SB Score:431

Accelerate integration development and provide a seamless marketplace experience for customers. Designed to meet developers' needs, quickly build and deliver native integrations.

Industry:
Ecommerce & Retail
Subindustry:
Ecommerce & Retail-Other

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
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SB Score:290

Bridge Medicines is a cutting-edge drug discovery company. They specialize in developing innovative medicines to address unmet medical needs.

Industry:
Healthtech
Subindustry:
Pharmaceuticals

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
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SB Score:297

RENEW Energy is a dynamic company specializing in asset management services for renewable energy projects. They empower clients to efficiently manage their investments in sustainable energy, ensuring optimal performance and environmental benefits.

Industry:
Energy & Environment
Subindustry:
Energy

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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Total amount:15

Top Hiring Startups in Sioux Falls by Employee Number

The top three hiring startups in Sioux Falls have an median employee size that is between [101-250]
SB Score:297

RENEW Energy is a dynamic company specializing in asset management services for renewable energy projects. They empower clients to efficiently manage their investments in sustainable energy, ensuring optimal performance and environmental benefits.

Industry:
Energy & Environment
Subindustry:
Energy

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
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SB Score:241

Bluepeak facilitates connectivity and accessibility through infrastructure investments, resource provision, and information dissemination, ultimately bringing people together.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:431

Accelerate integration development and provide a seamless marketplace experience for customers. Designed to meet developers' needs, quickly build and deliver native integrations.

Industry:
Ecommerce & Retail
Subindustry:
Ecommerce & Retail-Other

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:334

Connecting top C-suite leaders worldwide, this trusted network provides a platform for collaboration and growth. Join the world's most respected community of executives for unparalleled networking opportunities and valuable insights.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page

Total amount:15

Explore the Startup Ecosystem of Sioux Falls

National Rank

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147th

2

Regional Rank

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166th

2

Global Rank

(WorldWide)

506th

4

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Top Cities for Startups in United States - Ranked by StartupBlink
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710.966
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251.377
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121.937
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109.679
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