15 Top startups in Sioux Falls for April 2025

We rank Prismatic, Bridge Medicines and RENEW Energy in Sioux Falls along with 12 other startups based on an algorithm that scores startups based on total investment, employee count, and quarterly website traffic. Sioux Falls startup ecosystem ranks #506 globally and #147 in United States.

Powered by:

Category

Startups

Unicorns

Exits

Coworking Spaces

Accelerators

Best Startups in Sioux Falls for 2025

SB Score:402

Accelerate integration development and provide a seamless marketplace experience for customers. Designed to meet developers' needs, quickly build and deliver native integrations.

Industry:
Ecommerce & Retail
Subindustry:
Ecommerce & Retail-Other

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:285

Bridge Medicines is a cutting-edge drug discovery company. They specialize in developing innovative medicines to address unmet medical needs.

Industry:
Healthtech
Subindustry:
Pharmaceuticals

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:280

RENEW Energy is a dynamic company specializing in asset management services for renewable energy projects. They empower clients to efficiently manage their investments in sustainable energy, ensuring optimal performance and environmental benefits.

Industry:
Energy & Environment
Subindustry:
Energy

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:263

Connecting top C-suite leaders worldwide, this trusted network provides a platform for collaboration and growth. Join the world's most respected community of executives for unparalleled networking opportunities and valuable insights.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:241

Bluepeak facilitates connectivity and accessibility through infrastructure investments, resource provision, and information dissemination, ultimately bringing people together.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page

Advanced Remote Sensing, based in Sioux Falls, South Dakota, offers cutting-edge satellite imagery services for various industries. Founded in 2018, the company provides high-quality data for informed decision-making.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:192

BlueDop Medical is an innovative vascular expert software based in Sioux Falls, South Dakota. It provides healthcare providers with valuable insights and actionable data for better patient care.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:127

Four Percent is a rapidly growing community for modern entrepreneurs, offering top-notch education, tools, resources, and a supportive network to help them excel in their ventures. Join us to become a successful digital entrepreneur and reach your full potential.

Industry:
Marketing & Sales
Subindustry:
Digital Marketing

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:120

Sandbox is a digital technology community offering seminars, instructional videos, and tool recommendations for businesses. Dive into online resources to better understand and leverage digital tools.

Industry:
Edtech
Subindustry:
Edtech

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page

Total amount:15

Top 5 Software & Data Startups in Sioux Falls for 2025

The top three Software & Data startups in Sioux Falls have raised more than USD 1.28M. Sioux Falls startup ecosystem ranks #505 globally for the Software & Data industry.
SB Score:263

Connecting top C-suite leaders worldwide, this trusted network provides a platform for collaboration and growth. Join the world's most respected community of executives for unparalleled networking opportunities and valuable insights.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:241

Bluepeak facilitates connectivity and accessibility through infrastructure investments, resource provision, and information dissemination, ultimately bringing people together.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page

Advanced Remote Sensing, based in Sioux Falls, South Dakota, offers cutting-edge satellite imagery services for various industries. Founded in 2018, the company provides high-quality data for informed decision-making.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page

Total amount:5

Top 2 Fintech Startups in Sioux Falls for 2025

Sioux Falls startup ecosystem ranks among the top 10 locations in the world for startups in Fintech, holding the falseth position.
SB Score:102

CoinLion is a digital currency exchange and portfolio management platform that empowers users to navigate the complexities of digital assets. By incentivizing information sharing, it simplifies asset management and rewards participation, creating an engaging community focused on enhancing the digital investment experience.

Industry:
Fintech
Subindustry:
Blockchain

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:33

InsuranceLibrary.com is the go-to platform for insurance questions, connecting consumers with licensed agents for expert answers. With over 15,000 responses, the site helps thousands daily, providing clarity and guidance on insurance matters.

Industry:
Fintech
Subindustry:
Personal Finance

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page

Total amount:2

Top 2 Edtech Startups in Sioux Falls for 2025

Sioux Falls startup ecosystem ranks among the top 10 locations in the world for startups in Edtech, holding the falseth position.
SB Score:120

Sandbox is a digital technology community offering seminars, instructional videos, and tool recommendations for businesses. Dive into online resources to better understand and leverage digital tools.

Industry:
Edtech
Subindustry:
Edtech

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page

LCB Academy is a tech camp for kids in grades K-12. Students learn programming, science, math, and engineering while doing what they love. Dive into a fun, educational experience at LCB and discover the world of technology!

Industry:
Edtech
Subindustry:
Edtech

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page

Total amount:2

Most Funded Startups in Sioux Falls for 2025

The top three most funded startups in Sioux Falls have raised total funding of more than USD 54.5M. Prismatic has 3.33% more funding than Bridge Medicines.
SB Score:402

Accelerate integration development and provide a seamless marketplace experience for customers. Designed to meet developers' needs, quickly build and deliver native integrations.

Industry:
Ecommerce & Retail
Subindustry:
Ecommerce & Retail-Other

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:285

Bridge Medicines is a cutting-edge drug discovery company. They specialize in developing innovative medicines to address unmet medical needs.

Industry:
Healthtech
Subindustry:
Pharmaceuticals

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:280

RENEW Energy is a dynamic company specializing in asset management services for renewable energy projects. They empower clients to efficiently manage their investments in sustainable energy, ensuring optimal performance and environmental benefits.

Industry:
Energy & Environment
Subindustry:
Energy

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page

Total amount:15

Top Hiring Startups in Sioux Falls by Employee Number

The top three hiring startups in Sioux Falls have an median employee size that is between [101-250]
SB Score:280

RENEW Energy is a dynamic company specializing in asset management services for renewable energy projects. They empower clients to efficiently manage their investments in sustainable energy, ensuring optimal performance and environmental benefits.

Industry:
Energy & Environment
Subindustry:
Energy

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:241

Bluepeak facilitates connectivity and accessibility through infrastructure investments, resource provision, and information dissemination, ultimately bringing people together.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:402

Accelerate integration development and provide a seamless marketplace experience for customers. Designed to meet developers' needs, quickly build and deliver native integrations.

Industry:
Ecommerce & Retail
Subindustry:
Ecommerce & Retail-Other

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:285

Bridge Medicines is a cutting-edge drug discovery company. They specialize in developing innovative medicines to address unmet medical needs.

Industry:
Healthtech
Subindustry:
Pharmaceuticals

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page

Total amount:15

Explore the Startup Ecosystem of Sioux Falls

National Rank

(undefined)

new

Regional Rank

(undefined)

166th

2

Global Rank

(WorldWide)

506th

4

Visit

Top Cities for Startups in United States - Ranked by StartupBlink

StartupBlink ranks the startup ecosystems of more than 100 countries and 1,000 cities. Download our latest Global Startup Ecosystem Report.
Pro
Pro
Pro
Pro
2024 National Rank CityGlobal Rank
informational icon
Total Score

Access subscores for 1000 cities and 100 countries

informational icon
Quantity Score
informational icon
Quality Score
informational icon
Business Score
1st
0
1st
0
710.966
00.00
00.00
00.00
2nd
0
2nd
0
251.377
00.00
00.00
00.00
3rd
0
4th
0
121.937
00.00
00.00
00.00
4th
0
5th
0
109.679
00.00
00.00
00.00
5th
0
12th
0
52.052
00.00
00.00
00.00
6th
0
15th
0
42.256
00.00
00.00
00.00
7th
+
1
17th
+
4
41.259
00.00
00.00
00.00
8th
-
1
19th
-
1
37.971
00.00
00.00
00.00
9th
0
24th
-
2
34.098
00.00
00.00
00.00
10th
0
25th
+
1
33.768
00.00
00.00
00.00
Microsoft Excel icon
Download CSV file
Pro