17 Top startups in Santa Clarita for April 2025

We rank Scorpion, SetPoint Medical and Kadenze in Santa Clarita along with 14 other startups based on an algorithm that scores startups based on total investment, employee count, and quarterly website traffic. Santa Clarita is part of Los Angeles Area startup ecosystem which ranks #4 globally and #3 in North America.

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Best Startups in Santa Clarita for 2025

SB Score:456

SetPoint Medical uses unique implantable bioelectronic devices to help patients suffering from severe inflammatory diseases. Their innovative technology offers targeted treatment options for those in need, providing relief and improving quality of life.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:377

Kadenze, a tech company based in Valencia, offers innovative solutions in the technology sector. They provide cutting-edge services to enhance user experience and drive technological advancements.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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SB Score:369

Valencia Technologies specializes in creating coin-sized electroceuticals for treating hypertension. Their innovative devices are developed, manufactured, and sold to provide effective treatment in a compact form.

Industry:
Healthtech
Subindustry:
Health Care

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SB Score:366

PayForward is a cutting-edge Social Financial Platform that propels users forward. It offers a seamless way to connect with others and pay it forward financially, ultimately helping users achieve their goals and dreams.

Industry:
Fintech
Subindustry:
Financial Services

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SB Score:351

H2scan Corporation is headquartered in Valencia, California, and was formed September 18, 2002 through an MBO with capital assistance from Vancouver-based Chrysalix Energy Limited Partnership and Ravinia Venture Fund. The company was created upon the purchase of all sensor assets of DCH Sensor Corporation. Ballard Power Systems Inc., Shell Hydrogen, and Duke Energy formed Chrysalix (www.chrysalix.com) in July 2001. This Partnership has since been joined by The BOC Group, BASF Venture Capital, The Mitsubishi Corporation. The fundamental technology of H2scan sensor systems was developed by the U.S. National Laboratory at Sandia. H2scan has significantly improved upon this technology through US patents and manufacturing trade secrets.

Industry:
Hardware & IoT
Subindustry:
Consumer Electronics

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SB Score:333

Tombot creates robotic animals to improve the lives of those dealing with health challenges, offering innovative companions for individuals, families, and communities.

Industry:
Healthtech
Subindustry:
Assisted Living

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SB Score:318

Celitech is revolutionizing connectivity with a digital-only platform providing global cellular data access through a user-friendly web app and API.

Industry:
Software & Data
Subindustry:
Cloud

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SB Score:277

Hart & Main provides a versatile event venue with both indoor and outdoor spaces, perfect for any occasion. Featuring a full commercial kitchen, a stylish bar, a stunning rooftop deck, and elegant bridal and groom suites, the venue exudes a charming Mid-century vibe for unforgettable celebrations.

Industry:
Social & Leisure
Subindustry:
Entertainment

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SB Score:269

Help Worldwide enables users to effortlessly donate to charity through their everyday shopping. By simply shopping with partner brands, users can generate continuous charitable donations without any extra cost. Join Help Worldwide today to make a difference with every purchase.

Industry:
Social & Leisure
Subindustry:
Communities

National Rank (United States)

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Regional Rank (North America)

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Total amount:17

Top 5 Software & Data Startups in Santa Clarita for 2025

The top three Software & Data startups in Santa Clarita have raised more than USD 10.4M. Santa Clarita is part of Los Angeles Area startup ecosystem which ranks #6 globally for the Software & Data industry.
SB Score:377

Kadenze, a tech company based in Valencia, offers innovative solutions in the technology sector. They provide cutting-edge services to enhance user experience and drive technological advancements.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

0

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Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

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SB Score:318

Celitech is revolutionizing connectivity with a digital-only platform providing global cellular data access through a user-friendly web app and API.

Industry:
Software & Data
Subindustry:
Cloud

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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Total amount:5

Top 2 Social & Leisure Startups in Santa Clarita for 2025

The top three Social & Leisure startups in Santa Clarita have raised more than USD 10.5M. Santa Clarita is part of Los Angeles Area startup ecosystem which ranks #4 globally for the Social & Leisure industry.
SB Score:277

Hart & Main provides a versatile event venue with both indoor and outdoor spaces, perfect for any occasion. Featuring a full commercial kitchen, a stylish bar, a stunning rooftop deck, and elegant bridal and groom suites, the venue exudes a charming Mid-century vibe for unforgettable celebrations.

Industry:
Social & Leisure
Subindustry:
Entertainment

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:269

Help Worldwide enables users to effortlessly donate to charity through their everyday shopping. By simply shopping with partner brands, users can generate continuous charitable donations without any extra cost. Join Help Worldwide today to make a difference with every purchase.

Industry:
Social & Leisure
Subindustry:
Communities

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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Total amount:2

Most Funded Startups in Santa Clarita for 2025

The top three most funded startups in Santa Clarita have raised total funding of more than USD 742M. SetPoint Medical has 3.24% more funding than H2scan.
SB Score:456

SetPoint Medical uses unique implantable bioelectronic devices to help patients suffering from severe inflammatory diseases. Their innovative technology offers targeted treatment options for those in need, providing relief and improving quality of life.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

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SB Score:351

H2scan Corporation is headquartered in Valencia, California, and was formed September 18, 2002 through an MBO with capital assistance from Vancouver-based Chrysalix Energy Limited Partnership and Ravinia Venture Fund. The company was created upon the purchase of all sensor assets of DCH Sensor Corporation. Ballard Power Systems Inc., Shell Hydrogen, and Duke Energy formed Chrysalix (www.chrysalix.com) in July 2001. This Partnership has since been joined by The BOC Group, BASF Venture Capital, The Mitsubishi Corporation. The fundamental technology of H2scan sensor systems was developed by the U.S. National Laboratory at Sandia. H2scan has significantly improved upon this technology through US patents and manufacturing trade secrets.

Industry:
Hardware & IoT
Subindustry:
Consumer Electronics

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page

Total amount:17

Top Hiring Startups in Santa Clarita by Employee Number

The top three hiring startups in Santa Clarita have an median employee size that is between [101-250]
SB Score:456

SetPoint Medical uses unique implantable bioelectronic devices to help patients suffering from severe inflammatory diseases. Their innovative technology offers targeted treatment options for those in need, providing relief and improving quality of life.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:369

Valencia Technologies specializes in creating coin-sized electroceuticals for treating hypertension. Their innovative devices are developed, manufactured, and sold to provide effective treatment in a compact form.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:366

PayForward is a cutting-edge Social Financial Platform that propels users forward. It offers a seamless way to connect with others and pay it forward financially, ultimately helping users achieve their goals and dreams.

Industry:
Fintech
Subindustry:
Financial Services

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page

Total amount:17

Explore the Startup Ecosystem of Santa Clarita

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Top Cities for Startups in United States - Ranked by StartupBlink

StartupBlink ranks the startup ecosystems of more than 100 countries and 1,000 cities. Download our latest Global Startup Ecosystem Report.
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Quantity Score
Quality ScoreBusiness Score
1st
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1st
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710.966
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2nd
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2nd
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251.377
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3rd
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4th
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121.937
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4th
0
5th
0
109.679
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