465 Top startups in Santa Clara for April 2025

We rank Chegg, Palo Alto Networks and Malwarebytes in Santa Clara along with 462 other startups based on an algorithm that scores startups based on total investment, employee count, and quarterly website traffic. Santa Clara is part of San Francisco Bay startup ecosystem which ranks #1 globally and #1 in North America.

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Top Unicorn Startups in Santa Clara for 2025

Five startups have achieved unicorn status by exceeding USD 1 billion in valuation. Collectively, the top three unicorns in Santa Clara have raised more than USD 27.5B.
SB Score:597

Netskope links users to the internet, any application, and their infrastructure from any device, on or off the network, in a secure and fast manner. Unlike competitors who force security and networking choices, their global security private cloud offers complete computation capabilities at the edge. It's fast everywhere, data-driven, and cloud-savvy, all while promoting good digital citizenship and lowering the total cost of ownership.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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SB Score:563

Dremio is a data lake engine that offers tools to help streamline and curate data. It accelerates analytical processing for BI tools, data science, machine learning, and SQL clients, learns from data and queries and makes data engineers, analysts, and data scientists more productive, and helps data consumers to be more self-sufficient. Jacques Nadeau and Tomer Shiran founded the company in 2015 in Mountain View, California.

Industry:
Software & Data
Subindustry:
Software

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SB Score:516

Aviatrix is a cutting-edge platform that offers enhanced security and operational insight across multiple cloud networks. Gain clarity and protection with this innovative solution for seamless cloud management.

Industry:
Software & Data
Subindustry:
Cloud

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Total amount:5

Best Startups in Santa Clara for 2025

SB Score:734

Chegg provides students with a comprehensive learning platform for universities and community colleges. It offers a range of services to help students succeed, including textbooks, study tools, and resources.

Industry:
Edtech
Subindustry:
Education-Other

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SB Score:665

Malwarebytes provides cutting-edge malware protection and removal services for individuals and businesses, safeguarding devices from cyber threats. Enhance your digital security with Malwarebytes' advanced solutions.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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SB Score:634

Securly develops a student safety platform. They are designed to help students and children surf the web safely and securely. Their platform is a cloud-based, web-filtering platform for school computers that, through language-sentiment analysis, also detects cyberbullying and self-harm behaviors, enabling teachers and parents to control and track websites used by students on school computers.

Industry:
Edtech
Subindustry:
Education-Other

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SB Score:622

PayNearMe offers a convenient web and mobile cash payments platform for online purchases and bill payments. Users can easily make transactions without the need for a credit card, making it a hassle-free way to manage finances on the go.

Industry:
Fintech
Subindustry:
Financial Services

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SB Score:620

DataStax is the company that powers generative AI applications with real-time, scalable data and production-ready vector data tools that generative AI applications need, and seamless integration with developers’ stacks of choice. The Astra DB vector database provides developers with elegant APIs, powerful real-time data pipelines, and complete ecosystem integrations to quickly build and deploy production-level AI applications.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

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SB Score:584

Arista Networks is a computer networking firm delivering cloud networking solutions for large data center and computer environments. It was founded to deliver software-driven cloud networking solutions for large data center and high-performance computing environments. With more than three million cloud networking ports being deployed worldwide, Arista delivers a portfolio of 1/10/40 and 100 GbE products that redefine network architectures, bring extensibility to networking, and dramatically change the price/performance of data center networks.

Industry:
Hardware & IoT
Subindustry:
Hardware

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SB Score:560

Bluwhale, founded in 2022, is an advanced AI platform that extracts and analyzes data from different blockchains to enhance NFT personalization and discovery. With cutting-edge technology, Bluwhale offers comprehensive blockchain content insights for users.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

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SB Score:555

Couchbase is a cutting-edge NoSQL cloud database designed for vital business applications. It provides high-performance storage and seamless scalability for companies seeking reliable data management solutions.

Industry:
Software & Data
Subindustry:
Data Analytics

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10th

WSO2
SB Score:545

Founded in 2005, WSO2 enables thousands of enterprises, including hundreds of the world’s largest corporations, top universities, and governments, to drive their digital transformation journeys—executing more than 60 trillion transactions and managing over 1 billion identities annually. WSO2's suite of tools for application development and customer identity and access management (CIAM) helps these organizations harness the full power of their APIs to securely create and deliver awesome digital experiences. Our API-first approach to software that runs on-premises and in the cloud helps developers and architects be more productive and rapidly compose digital products that enhance the user experience and deliver stakeholder value. WSO2 has over 800 employees worldwide, with offices in Australia, Brazil, Germany, India, Sri Lanka, the UAE, the UK, and the US.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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11th

Musely
SB Score:545

Musely offers an online platform for advanced medical skincare treatments. Users can access personalized skincare solutions through innovative technology, making it easy to achieve healthy and radiant skin.

Industry:
Marketing & Sales
Subindustry:
Content Marketing

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Total amount:465

Top 228 Software & Data Startups in Santa Clara for 2025

The top three Software & Data startups in Santa Clara have raised more than USD 1.34B. Santa Clara is part of San Francisco Bay startup ecosystem which ranks #1 globally for the Software & Data industry.
SB Score:665

Malwarebytes provides cutting-edge malware protection and removal services for individuals and businesses, safeguarding devices from cyber threats. Enhance your digital security with Malwarebytes' advanced solutions.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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SB Score:620

DataStax is the company that powers generative AI applications with real-time, scalable data and production-ready vector data tools that generative AI applications need, and seamless integration with developers’ stacks of choice. The Astra DB vector database provides developers with elegant APIs, powerful real-time data pipelines, and complete ecosystem integrations to quickly build and deploy production-level AI applications.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

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Total amount:228

Top 23 Fintech Startups in Santa Clara for 2025

The top three Fintech startups in Santa Clara have raised more than USD 374M. Santa Clara is part of San Francisco Bay startup ecosystem which ranks #1 globally for the Fintech industry.
SB Score:622

PayNearMe offers a convenient web and mobile cash payments platform for online purchases and bill payments. Users can easily make transactions without the need for a credit card, making it a hassle-free way to manage finances on the go.

Industry:
Fintech
Subindustry:
Financial Services

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SB Score:468

Roambee offers verifiably better supply chain visibility on demand, for on-time, in-full, in-condition delivery of shipments and assets anywhere in the world. 300+ enterprises are improving customer experience, service levels, product quality, cash cycles, business efficiencies, and sustainability with Roambee’s real-time insights & foresights. More than 50 of them are the top 100 global companies in the Pharma, Food, Electronics, Chemicals, Automotive, Packaging & Containers, and Logistics sectors. The company’s innovative AI-powered platform and end-to-end monitoring solutions deliver reliable, timely, and actionable “supply chain signals” that drive logistics automation. These curated supply chain signals are built on item-level, firsthand IoT sensor data and non-sensor inputs for high accuracy. This enables better multimodal ETAs, OTIF deliveries, 80%+ cold chain compliance, and more, including 4X+ ROI on supply chain assets such as bins, tanks, containers, work in process (WIP), and in-store/warehouse inventory by optimizing utilization and inventory levels. Gartner identifies Roambee as one of the 9 global supply chain technology companies in “2021 Gartner Tracking and Monitoring Business Process Context: Magic Quadrant for Real-Time Transposition Visibility Platforms.” Roambee is also behind the safe and timely distribution of temperature-sensitive vaccines for one of the largest global COVID-19 vaccine makers and food assistance for one of the largest humanitarian organizations in the world. Roambee is headquartered in the Silicon Valley, USA, and is globally operational with offices in Mexico, Brazil, UK, Switzerland, Germany, UAE, India, Singapore, Malaysia, and Indonesia.

Industry:
Fintech
Subindustry:
Financial Services

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SB Score:425

Auradine offers scalable, sustainable, and secure infrastructure solutions using cutting-edge blockchain, security, zero-knowledge, and AI technologies.

Industry:
Fintech
Subindustry:
Blockchain

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Total amount:23

Top 24 Healthtech Startups in Santa Clara for 2025

The top three Healthtech startups in Santa Clara have raised more than USD 488M. Santa Clara is part of San Francisco Bay startup ecosystem which ranks #1 globally for the Healthtech industry.
SB Score:494

Cyagen Biosciences is a cutting-edge biotech firm specializing in innovative solutions. They provide advanced services in the field of biotechnology, helping clients achieve their research goals with precision and efficiency.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:379

Apollomics is a cutting-edge biotech company focused on developing innovative cancer treatments that activate the immune system and target specific molecular pathways.

Industry:
Healthtech
Subindustry:
Health-Other

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3rd

Zeto
SB Score:361

Zeto revolutionizes EEG technology for hospitals with a wireless, zero-prep headset using dry electrodes. Their advanced cloud platform supports seamless data integration, offering a user-friendly and efficient solution for EEG monitoring.

Industry:
Healthtech
Subindustry:
Health Care

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Total amount:24

Most Funded Startups in Santa Clara for 2025

The top three most funded startups in Santa Clara have raised total funding of more than USD 2.26B. CloudMinds Technology has 1.34% more funding than DataStax.
SB Score:620

DataStax is the company that powers generative AI applications with real-time, scalable data and production-ready vector data tools that generative AI applications need, and seamless integration with developers’ stacks of choice. The Astra DB vector database provides developers with elegant APIs, powerful real-time data pipelines, and complete ecosystem integrations to quickly build and deploy production-level AI applications.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

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3rd

Plus
SB Score:476

Plus is a global provider of highly automated driving and fully autonomous driving solutions with headquarters in Silicon Valley, California, and operations in the U.S. and Germany. Named by Forbes as one of America’s Best Startup Employers and by Fast Company as one of the World’s Most Innovative Companies, Plus’s open autonomy technology platform is already powering vehicles in commercial use today. Working with leading vehicle manufacturers, fleets, and other technology companies globally, Plus is helping to make driving safer, more comfortable, and more sustainable. Plus has received a number of industry awards and distinctions for its transformative technology and business momentum from Fast Company, Forbes, Insider, Consumer Electronics Show, AUVSI, and others.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

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Total amount:465

Top Hiring Startups in Santa Clara by Employee Number

The top three hiring startups in Santa Clara have an median employee size that is between [10001+]
SB Score:466

MapR Technologies, a provider of the industry's next-generation data platform for AI and Analytics, enables enterprises to inject analytics into their business processes to increase revenue, reduce costs, and mitigate risks. MapR addresses the data complexities of high-scale and mission-critical distributed processing from the cloud to the edge, IoT analytics, and container persistence. Global 2000 enterprises trust the MapR Data Platform to help them solve their most complex AI and analytics challenges. Amazon, Cisco, Google, Microsoft, SAP, and other leading businesses are all part of the MapR ecosystem.

Industry:
Software & Data
Subindustry:
Data Analytics

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3rd

Kno
SB Score:428

Kno, Inc. is an education software company on a mission to ""Change The Way Students Learn."" We believe engagement is a leading indicator of learning success and grades are a lagging indicator. So we have partnered with over 80 leading publishers to offer more than 200,000 interactive titles that make learning more engaging, efficient, and social for students. They are the same books, only smarter. Each Kno eTextbook is packed with interactive features, assessments, and social sharing tools to engage students at the point of learning. And the Kno platform provides administrators and teachers with the tools they need to easily assign, manage, and monitor their digital learning content and assessments at an enterprise level. As part of Kno's commitment to ""Do Well, Do Good,"" Kno has created the Kno for Good program, a partnership with DonorsChoose.org, to provide $1 for every purchase made through Kno towards a classroom in need. Founded in 2009, Kno, Inc. has emerged as a leader in education software. Kno, Inc. has received funding from Andreessen Horowitz, Intel Capital, Goldman Sachs, FLOODGATE and GSV Capital, and is based in Santa Clara, California. For more information, go to www.kno.com, or follow Kno at http://facebook.com/GoodtoKno and http://twitter.com/GoodtoKNO

Industry:
Social & Leisure
Subindustry:
Communities

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SB Score:423

Zeevo, Inc. develops system-on-chip solutions for Bluetooth and other wireless communications applications.

Industry:
Hardware & IoT
Subindustry:
Hardware

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Total amount:465

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251.377
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121.937
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109.679
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