407 Top startups in Santa Clara for January 2025

We rank Chegg, Palo Alto Networks and Malwarebytes in Santa Clara along with 404 other startups based on an algorithm that scores startups based on total investment, employee count, and quarterly website traffic. Santa Clara is part of San Francisco Bay which ranks #1 globally and #1 in North America.

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Top Unicorn Startups in Santa Clara for 2025

Five startups have achieved unicorn status by exceeding USD 1 billion in valuation. Collectively, the top three unicorns in Santa Clara have raised more than USD 13.8B.
SB Score:638

Netskope provides cloud application security services to defend against online threats. Keep your data safe with Netskope's innovative software solutions.

Industry:
Software & Data
Subindustry:
Cybersecurity

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SB Score:583

Dremio, the Data Lake Engine, revolutionizes data analytics by enabling companies to maximize the value of their data quickly. Developed by industry experts and Apache Arrow creators, Dremio offers a fresh approach to data processing, ensuring faster insights and improved efficiency.

Industry:
Software & Data
Subindustry:
Data Analytics

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SB Score:547

Aviatrix is a cutting-edge platform that offers enhanced security and operational insight across multiple cloud networks. Gain clarity and protection with this innovative solution for seamless cloud management.

Industry:
Software & Data
Subindustry:
Cloud

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Total amount:5

Best Startups in Santa Clara for 2025

SB Score:775

Chegg provides students with a comprehensive learning platform for universities and community colleges. It offers a range of services to help students succeed, including textbooks, study tools, and resources.

Industry:
Edtech
Subindustry:
Education-Other

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SB Score:703

Malwarebytes provides cutting-edge malware protection and removal services for individuals and businesses, safeguarding devices from cyber threats. Enhance your digital security with Malwarebytes' advanced solutions.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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SB Score:660

Securly ensures safe online browsing for kids at school and home by blocking adult content, detecting cyber-bullies/predators, and filtering out inappropriate material from trusted websites like Google and YouTube. Founded by two security experts with over 17 years of experience, Securly is your one-step solution for online safety.

Industry:
Software & Data
Subindustry:
Cybersecurity

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SB Score:656

PayNearMe offers a convenient web and mobile cash payments platform for online purchases and bill payments. Users can easily make transactions without the need for a credit card, making it a hassle-free way to manage finances on the go.

Industry:
Fintech
Subindustry:
Financial Services

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SB Score:642

DataStax offers a powerful data management platform fueled by Apache Cassandra for high-scale applications. Empower your business with enterprise-grade solutions for managing vast amounts of data effortlessly.

Industry:
Software & Data
Subindustry:
Data Analytics

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SB Score:591

Ampere Computing, founded by a former Intel president, develops custom processors for AI and cloud computing. Their ARM-based chips cater to companies' cloud and datacenter needs, offering efficient solutions for advanced applications.

Industry:
Hardware & IoT
Subindustry:
Hardware

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SB Score:583

Revolutionize medical residency interview scheduling with a platform that streamlines the process for both applicants and programs. Save time, reduce stress, and increase efficiency with this innovative tool.

Industry:
Software & Data
Subindustry:
Data Analytics

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SB Score:574

Musely offers an online platform for advanced medical skincare treatments. Users can access personalized skincare solutions through innovative technology, making it easy to achieve healthy and radiant skin.

Industry:
Marketing & Sales
Subindustry:
Content Marketing

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10th

WSO2
SB Score:569

WSO2 is an innovative open source integration vendor, empowering startups to quickly develop digital products with its API-first platform.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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SB Score:565

Couchbase is a cutting-edge NoSQL cloud database designed for vital business applications. It provides high-performance storage and seamless scalability for companies seeking reliable data management solutions.

Industry:
Software & Data
Subindustry:
Data Analytics

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Total amount:407

Top 230 Software & Data Startups in Santa Clara for 2025

The top three Software & Data startups in Santa Clara have raised more than USD 1.12B. Santa Clara is part of San Francisco Bay which ranks #1 globally for the Software & Data industry.
SB Score:703

Malwarebytes provides cutting-edge malware protection and removal services for individuals and businesses, safeguarding devices from cyber threats. Enhance your digital security with Malwarebytes' advanced solutions.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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SB Score:660

Securly ensures safe online browsing for kids at school and home by blocking adult content, detecting cyber-bullies/predators, and filtering out inappropriate material from trusted websites like Google and YouTube. Founded by two security experts with over 17 years of experience, Securly is your one-step solution for online safety.

Industry:
Software & Data
Subindustry:
Cybersecurity

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Total amount:230

Top 19 Fintech Startups in Santa Clara for 2025

The top three Fintech startups in Santa Clara have raised more than USD 309M. Santa Clara is part of San Francisco Bay which ranks #1 globally for the Fintech industry.
SB Score:656

PayNearMe offers a convenient web and mobile cash payments platform for online purchases and bill payments. Users can easily make transactions without the need for a credit card, making it a hassle-free way to manage finances on the go.

Industry:
Fintech
Subindustry:
Financial Services

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SB Score:412

Auradine offers scalable, sustainable, and secure infrastructure solutions using cutting-edge blockchain, security, zero-knowledge, and AI technologies.

Industry:
Fintech
Subindustry:
Blockchain

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SB Score:412

Swirepay is a comprehensive global payments platform that empowers businesses with tools for seamless payments, invoicing, and lending, all in one place. By automating bookkeeping processes, it helps enhance cash flow and streamline financial management for businesses of all sizes.

Industry:
Fintech
Subindustry:
Financial Services

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Total amount:19

Top 22 Healthtech Startups in Santa Clara for 2025

The top three Healthtech startups in Santa Clara have raised more than USD 444M. Santa Clara is part of San Francisco Bay which ranks #1 globally for the Healthtech industry.
SB Score:491

Cyagen Biosciences is a cutting-edge biotech firm specializing in innovative solutions. They provide advanced services in the field of biotechnology, helping clients achieve their research goals with precision and efficiency.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:421

Apollomics is a cutting-edge biotech company focused on developing innovative cancer treatments that activate the immune system and target specific molecular pathways.

Industry:
Healthtech
Subindustry:
Health-Other

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3rd

Zeto
SB Score:391

Zeto revolutionizes EEG technology for hospitals with a wireless, zero-prep headset using dry electrodes. Their advanced cloud platform supports seamless data integration, offering a user-friendly and efficient solution for EEG monitoring.

Industry:
Healthtech
Subindustry:
Health Care

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Total amount:22

Most Funded Startups in Santa Clara for 2025

The top three most funded startups in Santa Clara have raised total funding of more than USD 1.81B. Ampere Computing has 0.13% more funding than CloudMinds Technology.
SB Score:591

Ampere Computing, founded by a former Intel president, develops custom processors for AI and cloud computing. Their ARM-based chips cater to companies' cloud and datacenter needs, offering efficient solutions for advanced applications.

Industry:
Hardware & IoT
Subindustry:
Hardware

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3rd

Plus
SB Score:522

Plus is a leading global provider of advanced automated and fully autonomous driving solutions, headquartered in Silicon Valley, California, with operations in the U.S. and Germany. The company focuses on transforming transportation through innovative technology, enhancing safety and efficiency on the roads.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

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Total amount:407

Top Hiring Startups in Santa Clara by Employee Number

The top three hiring startups in Santa Clara have an median employee size that is between [10001+]
SB Score:337

Hologic creates advanced software for analyzing and visualizing medical breast images, including computer-aided lesion detection and breast density calculations. Their products assist radiologists in efficiently viewing digital images, optimizing workflow, and storing medical records within a practice.

Industry:
Healthtech
Subindustry:
Health Care

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SB Score:197

Letsremotify simplifies the remote hiring process, connecting businesses, startups, and enterprises with pre-vetted US-based tech talent across 100+ skills in just 24 hours. It offers an efficient and rewarding solution for both employers and developers, streamlining the search for top talent in the digital landscape.

Industry:
Edtech
Subindustry:
Education-Other

National Rank (United States)

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SB Score:591

Ampere Computing, founded by a former Intel president, develops custom processors for AI and cloud computing. Their ARM-based chips cater to companies' cloud and datacenter needs, offering efficient solutions for advanced applications.

Industry:
Hardware & IoT
Subindustry:
Hardware

National Rank (United States)

0

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Regional Rank (North America)

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Global Rank (WorldWide)

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Total amount:407

Explore the Startup Ecosystem of Santa Clara

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Top Cities for Startups in United States - Ranked by StartupBlink
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Quantity Score
Quality ScoreBusiness Score
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710.966
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251.377
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121.937
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109.679
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