147 Top startups in San Antonio for April 2025

We rank Airrosti Rehab Centers, Xenex and Wellvana in San Antonio along with 144 other startups based on an algorithm that scores startups based on total investment, employee count, and quarterly website traffic. San Antonio startup ecosystem ranks #151 globally and #47 in United States.

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Best Startups in San Antonio for 2025

SB Score:403

Xenex provides a Pulsed Xenon Full Spectrum UV disinfection solution that effectively reduces bacteria associated with HAIs. This innovative technology offers a powerful defense against infection risks in healthcare settings.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

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SB Score:402

Wellvana is a collaborative model for independent medical providers, offering essential infrastructure for seamless integration.

Industry:
Healthtech
Subindustry:
Health Care

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SB Score:399

FloatMe is a developer of a financial wellness platform offering an app to help millennials cover cash gaps and improve their finances. Its platform provides transparent wage advances with no interest and overdraft protection. They feature bank-grade encryption and overdraft alerts that enable individuals to build an emergency stash and increase their financial health.

Industry:
Software & Data
Subindustry:
Apps

National Rank (United States)

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SB Score:395

Consert Inc. is focused on the design and implementation of intelligent energy distribution and management networks. It drives to join all the players in the energy market to its own network creating market solutions built entirely through opt-in participation. Consert Inc. was formed in 2008 and offers the most complete real-time, energy management and conservation ecosystem available today. Consert’s Energy Management Solution gives energy conservation the attributes of generation and offers utilities the opportunity to gain operational savings, address peak load with measurable and verifiable certainty, and realize new revenue streams, all by empowering consumers to set, monitors and reduce energy consumption. Over the years, Consert has proven itself time and time again with major utilities, including the nation’s largest municipal power and gas company. In addition to full-scale commercial program initiated as pilots for among others, Fayetteville Public Works Commission and Wake Electric Membership Corporation, Consert has partnered with CPS Energy of San Antonio – and its more than 700,000 customers – to reduce peak demand by more than 250 megawatts over the next three years.

Industry:
Energy & Environment
Subindustry:
Energy

National Rank (United States)

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Regional Rank (North America)

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Global Rank (WorldWide)

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United Allergy Services customizes treatment plans based on individual patient responses to allergens. They understand that each patient is unique and tailor their approach to ensure the most effective and personalized care.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

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Regional Rank (North America)

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SB Score:390

Merge offers an innovative ecosystem that includes the award-winning Merge Cube, Headset, Miniverse, and EDU Platform. This all-in-one, curriculum-aligned AR/VR solution enhances learning experiences in classrooms, libraries, STEM labs, and makerspaces, making immersive education accessible and engaging for students.

Industry:
Software & Data
Subindustry:
VR/AR

National Rank (United States)

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Regional Rank (North America)

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SB Score:389

Pozitivf makes fertility care more accessible for individuals and families. By streamlining the process, it empowers users to navigate their fertility journey with ease, offering support and resources tailored to their unique needs.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

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SB Score:388

The AirStrip Technologies platform securely delivers critical patient information, including virtual real-time waveform data, directly from hospital monitoring systems to a doctor or nurse's smart phone, laptop or desktop. The platform is completely reusable, scalable and data independent, and can be employed throughout the healthcare enterprise.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

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Regional Rank (North America)

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SB Score:388

Pocket Worlds is a mobile gaming company that offers engaging and immersive experiences for players on the go. With a focus on creating captivating virtual worlds, users can explore, compete, and socialize in a variety of games designed for their enjoyment.

Industry:
Social & Leisure
Subindustry:
Gaming

National Rank (United States)

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SB Score:382

Seno Medical is revolutionizing breast cancer detection with opto-acoustic imaging technology. Their innovative approach enhances accuracy and early detection.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

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Regional Rank (North America)

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Total amount:147

Top 45 Software & Data Startups in San Antonio for 2025

The top three Software & Data startups in San Antonio have raised more than USD 53M. San Antonio startup ecosystem ranks #134 globally for the Software & Data industry.
SB Score:399

FloatMe is a developer of a financial wellness platform offering an app to help millennials cover cash gaps and improve their finances. Its platform provides transparent wage advances with no interest and overdraft protection. They feature bank-grade encryption and overdraft alerts that enable individuals to build an emergency stash and increase their financial health.

Industry:
Software & Data
Subindustry:
Apps

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

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SB Score:390

Merge offers an innovative ecosystem that includes the award-winning Merge Cube, Headset, Miniverse, and EDU Platform. This all-in-one, curriculum-aligned AR/VR solution enhances learning experiences in classrooms, libraries, STEM labs, and makerspaces, making immersive education accessible and engaging for students.

Industry:
Software & Data
Subindustry:
VR/AR

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

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SB Score:381

With 98% of agencies lacking in-house website hosting expertise, X steps in to provide a solution. X enables agencies to quickly set up stable WordPress websites for their clients in under 2 minutes, eliminating the hassle of handling hosting needs.

Industry:
Software & Data
Subindustry:
Software and Data-Other

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

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Total amount:45

Top 33 Healthtech Startups in San Antonio for 2025

The top three Healthtech startups in San Antonio have raised more than USD 404M. San Antonio startup ecosystem ranks #93 globally for the Healthtech industry.
SB Score:403

Xenex provides a Pulsed Xenon Full Spectrum UV disinfection solution that effectively reduces bacteria associated with HAIs. This innovative technology offers a powerful defense against infection risks in healthcare settings.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

0

View

Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:402

Wellvana is a collaborative model for independent medical providers, offering essential infrastructure for seamless integration.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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Total amount:33

Top 12 Ecommerce & Retail Startups in San Antonio for 2025

The top three Ecommerce & Retail startups in San Antonio have raised more than USD 16.8M. San Antonio startup ecosystem ranks #176 globally for the Ecommerce & Retail industry.
SB Score:380

Sendspark is a dynamic video outreach platform that helps users easily create and send personalized video messages to connect with their audience in a more engaging way.

Industry:
Ecommerce & Retail
Subindustry:
Ecommerce & Retail-Other

National Rank (United States)

0

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Regional Rank (North America)

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Global Rank (WorldWide)

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SB Score:349

Stirista is a database marketing agency that specializes in B2B and B2C data, as well as email marketing services. They help businesses reach their target audience effectively through accurate and up-to-date data.

Industry:
Ecommerce & Retail
Subindustry:
Ecommerce & Retail-Other

National Rank (United States)

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Regional Rank (North America)

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Global Rank (WorldWide)

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SB Score:212

Zen Monkey provides convenient and delicious overnight oats for purchase on their online platform. Enjoy a hassle-free breakfast option that is ready to eat in the morning.

Industry:
Ecommerce & Retail
Subindustry:
Ecommerce

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

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Total amount:12

Most Funded Startups in San Antonio for 2025

The top three most funded startups in San Antonio have raised total funding of more than USD 404M. Airstrip Technologies has 0.76% more funding than VeraDermics.
SB Score:388

The AirStrip Technologies platform securely delivers critical patient information, including virtual real-time waveform data, directly from hospital monitoring systems to a doctor or nurse's smart phone, laptop or desktop. The platform is completely reusable, scalable and data independent, and can be employed throughout the healthcare enterprise.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
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SB Score:359

VeraDermics develops innovative pain-free solutions for skin conditions like warts using advanced drug delivery technology.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:402

Wellvana is a collaborative model for independent medical providers, offering essential infrastructure for seamless integration.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

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Total amount:147

Top Hiring Startups in San Antonio by Employee Number

The top three hiring startups in San Antonio have an median employee size that is between [5001-10000]
SB Score:395

Consert Inc. is focused on the design and implementation of intelligent energy distribution and management networks. It drives to join all the players in the energy market to its own network creating market solutions built entirely through opt-in participation. Consert Inc. was formed in 2008 and offers the most complete real-time, energy management and conservation ecosystem available today. Consert’s Energy Management Solution gives energy conservation the attributes of generation and offers utilities the opportunity to gain operational savings, address peak load with measurable and verifiable certainty, and realize new revenue streams, all by empowering consumers to set, monitors and reduce energy consumption. Over the years, Consert has proven itself time and time again with major utilities, including the nation’s largest municipal power and gas company. In addition to full-scale commercial program initiated as pilots for among others, Fayetteville Public Works Commission and Wake Electric Membership Corporation, Consert has partnered with CPS Energy of San Antonio – and its more than 700,000 customers – to reduce peak demand by more than 250 megawatts over the next three years.

Industry:
Energy & Environment
Subindustry:
Energy

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page

United Allergy Services customizes treatment plans based on individual patient responses to allergens. They understand that each patient is unique and tailor their approach to ensure the most effective and personalized care.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

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SB Score:136

Scaleworks is a private equity firm focused on investing in B2B SaaS companies. It aims to accelerate the growth of sustainable software businesses, fostering their success through strategic support and resources tailored to enhance performance and scalability in the competitive tech landscape.

Industry:
Ecommerce & Retail
Subindustry:
Consumer Goods

National Rank (United States)

0

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Regional Rank (North America)

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Global Rank (WorldWide)

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Total amount:147

Explore the Startup Ecosystem of San Antonio

National Rank

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Regional Rank

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55th

3

Global Rank

(WorldWide)

151st

3

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Top Cities for Startups in United States - Ranked by StartupBlink

StartupBlink ranks the startup ecosystems of more than 100 countries and 1,000 cities. Download our latest Global Startup Ecosystem Report.
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2024 National Rank CityGlobal Rank
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Total Score

Access subscores for 1000 cities and 100 countries

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Quantity Score
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Quality Score
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Business Score
1st
0
1st
0
710.966
00.00
00.00
00.00
2nd
0
2nd
0
251.377
00.00
00.00
00.00
3rd
0
4th
0
121.937
00.00
00.00
00.00
4th
0
5th
0
109.679
00.00
00.00
00.00
5th
0
12th
0
52.052
00.00
00.00
00.00
6th
0
15th
0
42.256
00.00
00.00
00.00
7th
+
1
17th
+
4
41.259
00.00
00.00
00.00
8th
-
1
19th
-
1
37.971
00.00
00.00
00.00
9th
0
24th
-
2
34.098
00.00
00.00
00.00
10th
0
25th
+
1
33.768
00.00
00.00
00.00
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