605 Top startups in Philadelphia for April 2025

We rank DuckDuckGo, Piano and Guru in Philadelphia along with 602 other startups based on an algorithm that scores startups based on total investment, employee count, and quarterly website traffic. Philadelphia startup ecosystem ranks #35 globally and #15 in United States.

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Top Unicorn Startups in Philadelphia for 2025

Four startups have achieved unicorn status by exceeding USD 1 billion in valuation. Collectively, the top three unicorns in Philadelphia have raised more than USD 21.2B.
SB Score:744

Gopuff is an on-demand delivery service for snacks and drinks. Users can order directly from their app for quick delivery to their doorstep. Get your favorite munchies and beverages delivered fast with Gopuff.

Industry:
Foodtech
Subindustry:
Online Food Ordering

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SB Score:696

Misfits Market offers affordable, high-quality food to combat food waste. They make it easier for people to access fresh produce while helping reduce waste.

Industry:
Ecommerce & Retail
Subindustry:
Ecommerce & Retail-Other

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SB Score:592

Phenom is the AI solution to help candidates find ideal jobs, assist employers in discovering top talent, and enable managers to build teams efficiently.

Industry:
Software & Data
Subindustry:
Software and Data-Other

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Total amount:4

Best Startups in Philadelphia for 2025

SB Score:859

DuckDuckGo is a privacy-focused search engine that prioritizes user anonymity by not tracking searches or behavior. With a commitment to online privacy, it offers straightforward search services without data profiling, setting a new standard for internet privacy protection through its platform and tools.

Industry:
Software & Data
Subindustry:
Software

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SB Score:635

Piano empowers organizations to analyze and shape customer behavior with a comprehensive platform.

Industry:
Marketing & Sales
Subindustry:
Marketing & Sales-Other

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3rd

Guru
SB Score:574

Guru is a knowledge management platform that enables teams and companies to effectively capture, distribute, and organize knowledge. The platform is designed to act as a single source of truth for information within an organization, allowing employees to easily access the information they require when they need it. Guru enables users to collect knowledge in real-time, whether through manual entry, browser extensions, or connection with other applications. This ensures that critical information is kept and available right away.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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SB Score:516

Honeygrow offers fresh stir-fries, smoothies, salads, and honey bar treats made with locally sourced ingredients. Enjoy a farm-to-table dining experience with a focus on quality and sustainability.

Industry:
Social & Leisure
Subindustry:
Social & Leisure-Other

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SB Score:495

The team is developing a platform for hosting events, catering to the creative individuals who want to bring people together around ideas. Unlike traditional ticket sale engines, this platform focuses on creating a space for collaboration and connection.

Industry:
Marketing & Sales
Subindustry:
Events

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SB Score:469

Crossbeam is the first and largest Ecosystem-Led Growth platform, used by over 19,000 companies to attract, convert, and grow customer relationships using their partner ecosystems.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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SB Score:465

Perpay is a user-friendly FinTech app helping underserved consumers make purchases, pay over time, and boost their credit.

Industry:
Fintech
Subindustry:
Financial Services

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SB Score:464

Cesium provides a comprehensive solution for organizing, viewing, and studying 3D geospatial information, simplifying the process for users.

Industry:
Software & Data
Subindustry:
Data Analytics

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SB Score:453

Chaikin Analytics provides high-quality stock analysis for both professional money managers and self-directed investors. Their proven platform delivers institutional-grade insights to help users make informed investment decisions.

Industry:
Software & Data
Subindustry:
Data Analytics

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SB Score:451

QuotaPath develops a sales commission tracking platform to simplify the process of maximizing quota attainment. Additionally, its platform provides compensation calculation and tracking, forecasting of attainments and earnings, offers a digital quota board to align quotas, and facilitates a digital organizational chart to track role and team changes over time, measure KPIs, and benchmark oneself against teammates. Founded in 2018, the company is headquartered in Philadelphia, Pennsylvania.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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Total amount:605

Top 190 Software & Data Startups in Philadelphia for 2025

The top three Software & Data startups in Philadelphia have raised more than USD 413M. Philadelphia startup ecosystem ranks #40 globally for the Software & Data industry.
SB Score:859

DuckDuckGo is a privacy-focused search engine that prioritizes user anonymity by not tracking searches or behavior. With a commitment to online privacy, it offers straightforward search services without data profiling, setting a new standard for internet privacy protection through its platform and tools.

Industry:
Software & Data
Subindustry:
Software

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2nd

Guru
SB Score:574

Guru is a knowledge management platform that enables teams and companies to effectively capture, distribute, and organize knowledge. The platform is designed to act as a single source of truth for information within an organization, allowing employees to easily access the information they require when they need it. Guru enables users to collect knowledge in real-time, whether through manual entry, browser extensions, or connection with other applications. This ensures that critical information is kept and available right away.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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Total amount:190

Top 104 Healthtech Startups in Philadelphia for 2025

The top three Healthtech startups in Philadelphia have raised more than USD 913M. Philadelphia startup ecosystem ranks #14 globally for the Healthtech industry.
SB Score:446

Century Therapeutics builds an allogeneic iPSC-derived cell therapy platform that integrates gene editing, protein engineering, technical development, and manufacturing capabilities to generate allogeneic, iPSC-derived NK and T cell therapies for both hematological and solid tumor malignancies with significant unmet medical needs.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:439

Patina is revolutionizing senior care by providing tailored healthcare for adults over 65, ensuring a dignified and personalized aging experience for all.

Industry:
Healthtech
Subindustry:
Health Care

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SB Score:436

Vitara Biomedical offers a revolutionary therapeutic platform for premature infants, based on natural physiological processes. Their innovative solution aims to enhance neonatal care by leveraging inspiration from nature.

Industry:
Healthtech
Subindustry:
Health Care

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Total amount:104

Top 79 Ecommerce & Retail Startups in Philadelphia for 2025

The top three Ecommerce & Retail startups in Philadelphia have raised more than USD 37.3M. Philadelphia startup ecosystem ranks #33 globally for the Ecommerce & Retail industry.
SB Score:432

Harness the power of nature for effective cleaning with our startup. Experience potent cleaning solutions derived from natural ingredients. Say goodbye to harsh chemicals and hello to a cleaner, greener home.

Industry:
Ecommerce & Retail
Subindustry:
Consumer Goods

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SB Score:378

Clove designs stylish sneakers specifically for healthcare professionals, blending comfort and functionality. Collaborating with a network of healthcare experts and innovative designers, Clove prioritizes the unique needs of those on the front lines, ensuring they have the footwear that supports their demanding work environments.

Industry:
Ecommerce & Retail
Subindustry:
Ecommerce & Retail-Other

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SB Score:370

NaturAll recommends refrigerating their haircare products for optimal freshness and effectiveness. Keep your hair products cool for a spa-like experience every time you pamper your hair.

Industry:
Ecommerce & Retail
Subindustry:
Ecommerce

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Total amount:79

Most Funded Startups in Philadelphia for 2025

The top three most funded startups in Philadelphia have raised total funding of more than USD 913M. Century Therapeutics has 0.62% more funding than Imvax.
SB Score:446

Century Therapeutics builds an allogeneic iPSC-derived cell therapy platform that integrates gene editing, protein engineering, technical development, and manufacturing capabilities to generate allogeneic, iPSC-derived NK and T cell therapies for both hematological and solid tumor malignancies with significant unmet medical needs.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:335

Imvax specializes in creating personalized vaccines and immunotherapy solutions for patients. Their innovative biotechnology aims to revolutionize treatment strategies.

Industry:
Healthtech
Subindustry:
Biotechnology

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Total amount:605

Top Hiring Startups in Philadelphia by Employee Number

The top three hiring startups in Philadelphia have an median employee size that is between [1001-5000]
SB Score:400

Clarivate Analytics empowers innovation with reliable insights and analytics. Their services help businesses and researchers make informed decisions faster.

Industry:
Software & Data
Subindustry:
Data Analytics

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SB Score:155

Comoto is the premier destination for motorcycle enthusiasts in America, offering a vast selection of aftermarket products through Cycle Gear, J&P Cycles, and RevZilla.com. With 150 stores nationwide and over 90 years of combined expertise, their knowledgeable team is dedicated to fueling every rider's passion for motorcycling.

Industry:
Ecommerce & Retail
Subindustry:
Ecommerce & Retail-Other

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SB Score:635

Piano empowers organizations to analyze and shape customer behavior with a comprehensive platform.

Industry:
Marketing & Sales
Subindustry:
Marketing & Sales-Other

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Total amount:605

Explore the Startup Ecosystem of Philadelphia

National Rank

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Regional Rank

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16th

1

Global Rank

(WorldWide)

35th

2

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Top Cities for Startups in United States - Ranked by StartupBlink

StartupBlink ranks the startup ecosystems of more than 100 countries and 1,000 cities. Download our latest Global Startup Ecosystem Report.
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2024 National Rank CityGlobal Rank
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Total Score

Access subscores for 1000 cities and 100 countries

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Quantity Score
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Quality Score
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Business Score
1st
0
1st
0
710.966
00.00
00.00
00.00
2nd
0
2nd
0
251.377
00.00
00.00
00.00
3rd
0
4th
0
121.937
00.00
00.00
00.00
4th
0
5th
0
109.679
00.00
00.00
00.00
5th
0
12th
0
52.052
00.00
00.00
00.00
6th
0
15th
0
42.256
00.00
00.00
00.00
7th
+
1
17th
+
4
41.259
00.00
00.00
00.00
8th
-
1
19th
-
1
37.971
00.00
00.00
00.00
9th
0
24th
-
2
34.098
00.00
00.00
00.00
10th
0
25th
+
1
33.768
00.00
00.00
00.00
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