11 Top startups in Ohio for January 2025

We rank Arcani Coil Care, Cleveland Alzheimer's Disease Research Center and Amplicore in Ohio along with 8 other startups based on an algorithm that scores startups based on total investment, employee count, and quarterly website traffic. Ohio is part of Columbus which ranks #88 globally and #34 in North America.

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Best Startups in Ohio for 2025

SB Score:336

Arcani Coil Care empowers women and children of all curl types to embrace and celebrate their natural textures. Through specialized products and guidance, it fosters confidence and appreciation for diverse curls, helping individuals unlock the full potential of their unique beauty.

Industry:
Ecommerce & Retail
Subindustry:
Consumer Goods

National Rank (United States)

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SB Score:293

Amplicore develops injectable therapeutics for degenerative musculoskeletal disorders, addressing unmet medical needs. With a regenerative approach, the company targets conditions such as osteoarthritis, cartilage damage, degenerative disc disease, and acute meniscus tears, aiming to enhance joint health and improve patients' quality of life.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

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SB Score:262

Graffle empowers developers to interact seamlessly with the Flow blockchain using any programming language. By providing APIs, webhooks, and websockets, Graffle removes technical barriers, enabling teams to effortlessly read, write, and query blockchain data.

Industry:
Software & Data
Subindustry:
SaaS

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SB Score:249

Wraparound Experts offers a range of services designed to support children and families both in schools and at home. The company specializes in behavioral and mental health services, as well as diversity training for children, educators, and families, fostering a more inclusive and supportive environment for all.

Industry:
Ecommerce & Retail
Subindustry:
Consumer Goods

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SB Score:232

Overnight Finance is a cutting-edge asset management protocol that offers conservative stablecoin investors passive yield products through delta-neutral strategies, ensuring a balanced approach to risk and reward. The platform simplifies investment management while maximizing returns in a stable and secure manner.

Industry:
Fintech
Subindustry:
Financial Services

National Rank (United States)

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Regional Rank (North America)

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SB Score:174

DeskViz Inc. is an innovative tech startup dedicated to advancing blockchain research and software development. By focusing on cutting-edge blockchain technologies, DeskViz aims to create a more secure, transparent, and open internet, empowering users and organizations to harness the full potential of decentralized solutions.

Industry:
Software & Data
Subindustry:
Apps

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Regional Rank (North America)

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SB Score:111

Premise Solutions excels in customer service, making them a top choice for IT needs. They go above and beyond to assist with technology decisions, earning them a loyal customer base.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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SB Score:36

DRM provides a comprehensive suite of marketing services, from website development and print design to PR and marketing automation. Their expertise includes campaign creation, corporate identity design, video production, and illustration to help startups elevate their brand and reach their target audience effectively.

Industry:
Marketing & Sales
Subindustry:
Adtech

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SB Score:24

Metasorbex is a pioneering deep-tech corporation focused on developing advanced materials designed to combat climate change. By innovating solutions for carbon capture and environmental restoration, Metasorbex aims to create sustainable technologies that effectively mitigate the impacts of climate change and promote a healthier planet for future generations.

Industry:
Energy & Environment
Subindustry:
Energy

National Rank (United States)

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Regional Rank (North America)

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SB Score:24

Pronity streamlines marketing strategy, cutting out excess and honing in on key drivers of business growth. Marketing is no longer a aimless mouse on a treadmill, but a focused force propelling businesses towards success with a solid foundation.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

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Regional Rank (North America)

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Total amount:11

Top 4 Software & Data Startups in Ohio for 2025

The top three Software & Data startups in Ohio have raised more than USD 3.91M. Ohio is part of Columbus which ranks #81 globally for the Software & Data industry.
SB Score:262

Graffle empowers developers to interact seamlessly with the Flow blockchain using any programming language. By providing APIs, webhooks, and websockets, Graffle removes technical barriers, enabling teams to effortlessly read, write, and query blockchain data.

Industry:
Software & Data
Subindustry:
SaaS

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:174

DeskViz Inc. is an innovative tech startup dedicated to advancing blockchain research and software development. By focusing on cutting-edge blockchain technologies, DeskViz aims to create a more secure, transparent, and open internet, empowering users and organizations to harness the full potential of decentralized solutions.

Industry:
Software & Data
Subindustry:
Apps

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:111

Premise Solutions excels in customer service, making them a top choice for IT needs. They go above and beyond to assist with technology decisions, earning them a loyal customer base.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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Total amount:4

Top 2 Healthtech Startups in Ohio for 2025

The top three Healthtech startups in Ohio have raised more than USD 19.4M. Ohio is part of Columbus which ranks #62 globally for the Healthtech industry.
SB Score:293

Amplicore develops injectable therapeutics for degenerative musculoskeletal disorders, addressing unmet medical needs. With a regenerative approach, the company targets conditions such as osteoarthritis, cartilage damage, degenerative disc disease, and acute meniscus tears, aiming to enhance joint health and improve patients' quality of life.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

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Total amount:2

Top 1 Fintech Startups in Ohio for 2025

The top three Fintech startups in Ohio have raised more than USD 1.7M. Ohio is part of Columbus which ranks #72 globally for the Fintech industry.
SB Score:232

Overnight Finance is a cutting-edge asset management protocol that offers conservative stablecoin investors passive yield products through delta-neutral strategies, ensuring a balanced approach to risk and reward. The platform simplifies investment management while maximizing returns in a stable and secure manner.

Industry:
Fintech
Subindustry:
Financial Services

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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Total amount:1

Most Funded Startups in Ohio for 2025

The top three most funded startups in Ohio have raised total funding of more than USD 23.2M. Cleveland Alzheimer's Disease Research Center has 2.85% more funding than Amplicore.
SB Score:293

Amplicore develops injectable therapeutics for degenerative musculoskeletal disorders, addressing unmet medical needs. With a regenerative approach, the company targets conditions such as osteoarthritis, cartilage damage, degenerative disc disease, and acute meniscus tears, aiming to enhance joint health and improve patients' quality of life.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:262

Graffle empowers developers to interact seamlessly with the Flow blockchain using any programming language. By providing APIs, webhooks, and websockets, Graffle removes technical barriers, enabling teams to effortlessly read, write, and query blockchain data.

Industry:
Software & Data
Subindustry:
SaaS

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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Total amount:11

Top Hiring Startups in Ohio by Employee Number

The top three hiring startups in Ohio have an median employee size that is between [11-50]
SB Score:111

Premise Solutions excels in customer service, making them a top choice for IT needs. They go above and beyond to assist with technology decisions, earning them a loyal customer base.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:336

Arcani Coil Care empowers women and children of all curl types to embrace and celebrate their natural textures. Through specialized products and guidance, it fosters confidence and appreciation for diverse curls, helping individuals unlock the full potential of their unique beauty.

Industry:
Ecommerce & Retail
Subindustry:
Consumer Goods

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:293

Amplicore develops injectable therapeutics for degenerative musculoskeletal disorders, addressing unmet medical needs. With a regenerative approach, the company targets conditions such as osteoarthritis, cartilage damage, degenerative disc disease, and acute meniscus tears, aiming to enhance joint health and improve patients' quality of life.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page

Total amount:11

Explore the Startup Ecosystem of Ohio

National Rank

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30th

6

Regional Rank

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34th

6

Global Rank

(WorldWide)

88th

17

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Top Cities for Startups in United States - Ranked by StartupBlink
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Quantity Score
Quality ScoreBusiness Score
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710.966
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251.377
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121.937
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5th
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109.679
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