21 Top startups in Natick for April 2025

We rank Sionna Therapeutics, Garuda Therapeutics and Ventus Therapeutics in Natick along with 18 other startups based on an algorithm that scores startups based on total investment, employee count, and quarterly website traffic. Natick is part of Boston Area startup ecosystem which ranks #5 globally and #4 in North America.

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Best Startups in Natick for 2025

SB Score:409

Sionna Therapeutics, established in late 2019, harnesses a decade of scientific investment from large pharmaceutical companies. With a dedicated team of experts, the company is committed to restoring normal CFTR function, aiming to transform the lives of those affected by cystic fibrosis.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:407

Garuda Therapeutics creates ready-to-use stem cell treatments for severe diseases, providing hope for those facing life-threatening conditions.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:362

Empassion Health offers comprehensive care services for patients with advanced illnesses. Founded in 2022, the company focuses on providing quality support and treatment for those in need.

Industry:
Healthtech
Subindustry:
Health Care

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SB Score:345

Introducing Planning Maestro: revolutionizing financial planning with intelligent analytics for modern finance offices. Streamline operations, improve decision-making, and boost productivity with this innovative platform.

Industry:
Software & Data
Subindustry:
Data Analytics

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SB Score:340

Allorion Therapeutics develops small molecule therapies for cancer and autoimmune diseases. Their focus is on creating innovative treatments to improve patient outcomes.

Industry:
Healthtech
Subindustry:
Medtech

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SB Score:308

Attestiv verifies the authenticity of digital media and data, making it easy to trust the information you see online. With their technology, users can ensure the validity of photos and videos, providing peace of mind in a world full of misinformation.

Industry:
Fintech
Subindustry:
Blockchain

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11th

DOTS
SB Score:302

DOTS is revolutionizing point of care detection with a groundbreaking diagnostics platform for consumers and industries. This innovative technology is changing the game in rapid detection, making it easier and more accessible than ever before.

Industry:
Healthtech
Subindustry:
Health-Other

National Rank (United States)

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Total amount:21

Top 14 Healthtech Startups in Natick for 2025

The top three Healthtech startups in Natick have raised more than USD 846M. Natick is part of Boston Area startup ecosystem which ranks #2 globally for the Healthtech industry.
SB Score:409

Sionna Therapeutics, established in late 2019, harnesses a decade of scientific investment from large pharmaceutical companies. With a dedicated team of experts, the company is committed to restoring normal CFTR function, aiming to transform the lives of those affected by cystic fibrosis.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

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SB Score:407

Garuda Therapeutics creates ready-to-use stem cell treatments for severe diseases, providing hope for those facing life-threatening conditions.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

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Regional Rank (North America)

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Total amount:14

Top 3 Software & Data Startups in Natick for 2025

The top three Software & Data startups in Natick have raised more than USD 32.6M. Natick is part of Boston Area startup ecosystem which ranks #5 globally for the Software & Data industry.
SB Score:345

Introducing Planning Maestro: revolutionizing financial planning with intelligent analytics for modern finance offices. Streamline operations, improve decision-making, and boost productivity with this innovative platform.

Industry:
Software & Data
Subindustry:
Data Analytics

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SB Score:300

Salesroom aims to be the leading remote selling platform for mid-market and enterprise B2B account executives, empowering them to enhance their sales processes and engage clients effectively. With innovative tools and features, it streamlines remote interactions, helping teams close deals faster and build lasting relationships.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

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SB Score:176

BrowserUp offers cutting-edge automation tools to streamline testing processes, enabling teams to catch bugs sooner in the development cycle. Boost your release cycle efficiency with BrowserUp's innovative solutions.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

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Total amount:3

Most Funded Startups in Natick for 2025

The top three most funded startups in Natick have raised total funding of more than USD 846M. Ventus Therapeutics has 0.27% more funding than Sionna Therapeutics.
SB Score:409

Sionna Therapeutics, established in late 2019, harnesses a decade of scientific investment from large pharmaceutical companies. With a dedicated team of experts, the company is committed to restoring normal CFTR function, aiming to transform the lives of those affected by cystic fibrosis.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:407

Garuda Therapeutics creates ready-to-use stem cell treatments for severe diseases, providing hope for those facing life-threatening conditions.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

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Regional Rank (North America)

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Total amount:21

Top Hiring Startups in Natick by Employee Number

The top three hiring startups in Natick have an median employee size that is between [51-100]
SB Score:407

Garuda Therapeutics creates ready-to-use stem cell treatments for severe diseases, providing hope for those facing life-threatening conditions.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:345

Introducing Planning Maestro: revolutionizing financial planning with intelligent analytics for modern finance offices. Streamline operations, improve decision-making, and boost productivity with this innovative platform.

Industry:
Software & Data
Subindustry:
Data Analytics

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

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SB Score:293

At Wasabi, enjoy simple, flavorful, and healthy food. Indulge in dishes that embody these qualities, delivered straight to your table.

Industry:
Foodtech
Subindustry:
Food Manufacturing

National Rank (United States)

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Total amount:21

Explore the Startup Ecosystem of Natick

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Top Cities for Startups in United States - Ranked by StartupBlink

StartupBlink ranks the startup ecosystems of more than 100 countries and 1,000 cities. Download our latest Global Startup Ecosystem Report.
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2024 National Rank CityGlobal Rank
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Total Score

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Quantity Score
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Quality Score
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Business Score
1st
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1st
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710.966
00.00
00.00
00.00
2nd
0
2nd
0
251.377
00.00
00.00
00.00
3rd
0
4th
0
121.937
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00.00
00.00
4th
0
5th
0
109.679
00.00
00.00
00.00
5th
0
12th
0
52.052
00.00
00.00
00.00
6th
0
15th
0
42.256
00.00
00.00
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+
1
17th
+
4
41.259
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00.00
00.00
8th
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1
19th
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1
37.971
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00.00
00.00
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0
24th
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2
34.098
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00.00
00.00
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0
25th
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1
33.768
00.00
00.00
00.00
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