29 Top startups in Littleton for January 2025

We rank Luxonis, Gallus Medical Detox Centers - Phoenix and JETCOOL Technologies in Littleton along with 26 other startups based on an algorithm that scores startups based on total investment, employee count, and quarterly website traffic. Littleton is part of Denver which ranks #31 globally and #14 in North America.

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Best Startups in Littleton for 2025

SB Score:400

Luxonis is a leader in spatial AI and computer vision, focusing on embedded machine learning technology. By offering open-source, MIT-licensed hardware and software, the company empowers developers with innovative tools for training and applying AI, advancing human-level perception in embedded systems.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

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SB Score:380

JETCOOL Technologies designs innovative cooling solutions for high-power electronics, offering compact and high-performance options. Their hardware startup focuses on providing efficient and effective cooling solutions for various electronic devices.

Industry:
Hardware & IoT
Subindustry:
Consumer Electronics

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SB Score:372

DBMEDx creates non-invasive patient monitoring devices using advanced scanning technology. Their devices offer accurate health data in real-time, revolutionizing the way healthcare is delivered.

Industry:
Healthtech
Subindustry:
Health Care

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SB Score:349

Nexo Therapeutics is a pioneering oncology company focused on discovering and developing innovative small molecule therapies for cancer patients who have limited treatment options. By harnessing cutting-edge science, Nexo aims to provide hope and improve outcomes for those in need of effective cancer care.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:337

CereScan offers cutting-edge functional brain imaging using a unique process. Their biotech services help clients visualize brain activity with precision and accuracy.

Industry:
Healthtech
Subindustry:
Biotechnology

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Infinite Power Solutions develops solid-state, rechargeable, thin-film micro-energy storage devices for clean technology applications. Their innovative technology offers sustainable power solutions in a compact form.

Industry:
Energy & Environment
Subindustry:
Cleantech

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Regional Rank (North America)

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SB Score:308

CyGlass offers cutting-edge threat detection solutions for mid-market customers, enabling them to identify and respond to advanced cyber threats that bypass traditional security measures.

Industry:
Hardware & IoT
Subindustry:
Hardware

National Rank (United States)

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SB Score:289

ExoTerra aims to expand space exploration by offering affordable access to a wider audience.

Industry:
Transportation
Subindustry:
Aerospace

National Rank (United States)

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Regional Rank (North America)

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SB Score:255

Emporia, based in Littleton, Colorado, is an electrical company specializing in smart home technology systems like energy monitors, smart plugs, and batteries. Founded in 2018, Emporia offers innovative solutions for creating energy-efficient homes.

Industry:
Energy & Environment
Subindustry:
Energy

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Regional Rank (North America)

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11th

Xairos
SB Score:250

Introducing a global timing service revolutionizing precision timing without relying on GPS. Offering accurate timing solutions worldwide, this service ensures reliable timekeeping for various applications.

Industry:
Software & Data
Subindustry:
Comtech

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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Total amount:29

Top 7 Software & Data Startups in Littleton for 2025

The top three Software & Data startups in Littleton have raised more than USD 6.25M. Littleton is part of Denver which ranks #18 globally for the Software & Data industry.
SB Score:400

Luxonis is a leader in spatial AI and computer vision, focusing on embedded machine learning technology. By offering open-source, MIT-licensed hardware and software, the company empowers developers with innovative tools for training and applying AI, advancing human-level perception in embedded systems.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:250

Introducing a global timing service revolutionizing precision timing without relying on GPS. Offering accurate timing solutions worldwide, this service ensures reliable timekeeping for various applications.

Industry:
Software & Data
Subindustry:
Comtech

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
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Total amount:7

Top 5 Healthtech Startups in Littleton for 2025

The top three Healthtech startups in Littleton have raised more than USD 81.9M. Littleton is part of Denver which ranks #13 globally for the Healthtech industry.
SB Score:372

DBMEDx creates non-invasive patient monitoring devices using advanced scanning technology. Their devices offer accurate health data in real-time, revolutionizing the way healthcare is delivered.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

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SB Score:349

Nexo Therapeutics is a pioneering oncology company focused on discovering and developing innovative small molecule therapies for cancer patients who have limited treatment options. By harnessing cutting-edge science, Nexo aims to provide hope and improve outcomes for those in need of effective cancer care.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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Total amount:5

Top 1 Social & Leisure Startups in Littleton for 2025

Littleton is part of Denver which ranks #17 globally for the Social & Leisure industry.

Total amount:1

Most Funded Startups in Littleton for 2025

The top three most funded startups in Littleton have raised total funding of more than USD 183M. Infinite Power Solutions has 0.43% more funding than Nexo Therapeutics.

Infinite Power Solutions develops solid-state, rechargeable, thin-film micro-energy storage devices for clean technology applications. Their innovative technology offers sustainable power solutions in a compact form.

Industry:
Energy & Environment
Subindustry:
Cleantech

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:349

Nexo Therapeutics is a pioneering oncology company focused on discovering and developing innovative small molecule therapies for cancer patients who have limited treatment options. By harnessing cutting-edge science, Nexo aims to provide hope and improve outcomes for those in need of effective cancer care.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:380

JETCOOL Technologies designs innovative cooling solutions for high-power electronics, offering compact and high-performance options. Their hardware startup focuses on providing efficient and effective cooling solutions for various electronic devices.

Industry:
Hardware & IoT
Subindustry:
Consumer Electronics

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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Total amount:29

Top Hiring Startups in Littleton by Employee Number

The top three hiring startups in Littleton have an median employee size that is between [51-100]
SB Score:400

Luxonis is a leader in spatial AI and computer vision, focusing on embedded machine learning technology. By offering open-source, MIT-licensed hardware and software, the company empowers developers with innovative tools for training and applying AI, advancing human-level perception in embedded systems.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:255

Emporia, based in Littleton, Colorado, is an electrical company specializing in smart home technology systems like energy monitors, smart plugs, and batteries. Founded in 2018, Emporia offers innovative solutions for creating energy-efficient homes.

Industry:
Energy & Environment
Subindustry:
Energy

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:380

JETCOOL Technologies designs innovative cooling solutions for high-power electronics, offering compact and high-performance options. Their hardware startup focuses on providing efficient and effective cooling solutions for various electronic devices.

Industry:
Hardware & IoT
Subindustry:
Consumer Electronics

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page

Total amount:29

Explore the Startup Ecosystem of Littleton

National Rank

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13th

1

Regional Rank

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14th

1

Global Rank

(WorldWide)

31st

0

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251.377
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121.937
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109.679
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