239 Top startups in Indianapolis for April 2025

We rank Anagin, Jobvite and Community Health Network in Indianapolis along with 236 other startups based on an algorithm that scores startups based on total investment, employee count, and quarterly website traffic. Indianapolis startup ecosystem ranks #110 globally and #38 in United States.

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Best Startups in Indianapolis for 2025

SB Score:644

Anagin is creating innovative treatments for neuropsychiatric conditions, targeting root causes with minimal side effects. Their goal is to revolutionize therapy options for these disorders.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:632

Jobvite offers comprehensive talent acquisition solutions to streamline recruiting processes, improve hiring outcomes, and reduce costs. Their software and services enhance recruitment quality, efficiency, and affordability for businesses of all sizes.

Industry:
Software & Data
Subindustry:
Data Analytics

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Community Health Network is a nonprofit health system that facilitates specialty and acute care hospitals, surgery centers, home care services, and behavioral and employer health services. Its health services focus on breast and cancer care, diet and nutrition, digestive health, fertility and home care, genetic testing and counselling, medical imaging, mental and behavioral health, neuroscience, and more. Community Health Network offers an online platform that enables its customers to find information and book the services of doctors, and pay bills. It also provides its customers with financial assistance. Community Health Network was founded in 1956 and is based in Indianapolis, Indiana.

Industry:
Social & Leisure
Subindustry:
Communities

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SB Score:536

Empowering successful in-person, virtual, and hybrid events. A versatile solution for all event formats, ensuring seamless execution and maximum impact.

Industry:
Marketing & Sales
Subindustry:
Events

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OneCause Fundraising Solutions empowers nonprofits to maximize donations and expand their donor base. With our innovative platform, organizations can easily raise funds and connect with more supporters to further their mission.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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SB Score:514

ZergNet is the only content recommendation company focused on sending incremental traffic & unique visitors to our partners at scale. In exchange for implementing our content recommendation module, we promote your content on our publishing partners including: Conde Nast, Time, NBC, AOL, Viacom, Warner Bros, Rodale, Wenner, Fox, American Media and most major media companies. Return traffic can be specifically targeted to areas you care about - video, sponsored sections, galleries, etc. Our larger partners get hundreds of thousands of new unique visitors every day from us - driving a significant increase in sales revenue.

Industry:
Marketing & Sales
Subindustry:
Adtech

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SB Score:481

Bloomerang empowers nonprofits to connect with and retain their supporters through a user-friendly donor database solution. By incorporating the latest fundraising strategies and technology, Bloomerang helps organizations boost revenue and decrease donor turnover, all while providing valuable insights for successful fundraising efforts.

Industry:
Software & Data
Subindustry:
Software and Data-Other

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8th

Zylo
SB Score:477

As the leader in SaaS Management, Zylo empowers companies to discover, optimize and govern their SaaS applications while elevating the employee experience. Organizations large and small trust Zylo’s enterprise-proven technology and unparalleled SaaS Management expertise to optimize more than 30 million SaaS licenses and $7 billion in SaaS spend. Zylo’s patent-pending, AI-powered Discovery Engine provides continual, frictionless monitoring of SaaS spend, licenses, and usage to create the industry’s most trusted SaaS system of record. Fueled by more data than any other provider, Zylo delivers actionable insights that allow you to take action quickly to optimize growing SaaS portfolios. For more information, visit zylo.com.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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SB Score:471

BrüMate is the go-to brand for top-quality outdoor drinkware and coolers, perfect for any adventure. Their innovative products ensure your drinks stay cold and refreshing wherever you go, making BrüMate a must-have for outdoor enthusiasts.

Industry:
Ecommerce & Retail
Subindustry:
Ecommerce

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SB Score:443

Appirio accelerates the cloud-powered business, helping enterprises achieve real results from cloud applications and platforms like salesforce.com, Google and Workday. Appirio has worked with more than 500 enterprise customers including organizations like City of Los Angeles, Facebook, Flextronics, Home Depot, International Hotels Group, Japan Post Network, Ltd., L'Oreal, NetApp, NYU, Starbucks, Thomson Reuters and VMware. Appirio's technology-enabled professional services are supported by a team of nearly 500 cloud experts and CloudSpokes (www.cloudspokes.com), a more than 70,000 person-strong global cloud developer community. The company's expertise and innovative brokerage technology have been recognized by organizations such as the World Economic Forum, Bloomberg BusinessWeek, InformationWeek, Gartner, and IDC. Appirio has offices in the U.S., Europe and Japan, and is backed by Sequoia Capital, GGV Capital and General Atlantic.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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SB Score:440

ClusterTruck delivers delicious food straight to your door through their online platform. Enjoy a wide variety of options without leaving the comfort of your home.

Industry:
Foodtech
Subindustry:
Food and Beverage

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Total amount:239

Top 91 Software & Data Startups in Indianapolis for 2025

The top three Software & Data startups in Indianapolis have raised more than USD 250M. Indianapolis startup ecosystem ranks #103 globally for the Software & Data industry.
SB Score:632

Jobvite offers comprehensive talent acquisition solutions to streamline recruiting processes, improve hiring outcomes, and reduce costs. Their software and services enhance recruitment quality, efficiency, and affordability for businesses of all sizes.

Industry:
Software & Data
Subindustry:
Data Analytics

National Rank (United States)

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OneCause Fundraising Solutions empowers nonprofits to maximize donations and expand their donor base. With our innovative platform, organizations can easily raise funds and connect with more supporters to further their mission.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

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SB Score:481

Bloomerang empowers nonprofits to connect with and retain their supporters through a user-friendly donor database solution. By incorporating the latest fundraising strategies and technology, Bloomerang helps organizations boost revenue and decrease donor turnover, all while providing valuable insights for successful fundraising efforts.

Industry:
Software & Data
Subindustry:
Software and Data-Other

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Total amount:91

Top 10 Hardware & IoT Startups in Indianapolis for 2025

The top three Hardware & IoT startups in Indianapolis have raised more than USD 25M. Indianapolis startup ecosystem ranks #68 globally for the Hardware & IoT industry.
SB Score:338

Elate streamlines business operations by integrating internal technologies and data to drive successful outcomes.

Industry:
Hardware & IoT
Subindustry:
Hardware

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SB Score:311

West Fork Whiskey crafts, sells, and distributes exceptional whiskey. Experience the art of distillation with our small-batch, handcrafted spirits, perfect for whiskey enthusiasts and connoisseurs alike.

Industry:
Hardware & IoT
Subindustry:
Manufacturing

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SB Score:294

Amplio enables you to reclaim control of your supply chain by making sourcing more cost-effective.

Industry:
Hardware & IoT
Subindustry:
Hardware

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Total amount:10

Top 30 Healthtech Startups in Indianapolis for 2025

The top three Healthtech startups in Indianapolis have raised more than USD 159M. Indianapolis startup ecosystem ranks #112 globally for the Healthtech industry.
SB Score:644

Anagin is creating innovative treatments for neuropsychiatric conditions, targeting root causes with minimal side effects. Their goal is to revolutionize therapy options for these disorders.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

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Regional Rank (North America)

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2nd

hc1
SB Score:380

HC1 empowers health systems, laboratories, and physicians with real-time lab stewardship and precision prescribing. Streamline processes and improve patient care with cutting-edge technology.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

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SB Score:357

Prevounce is a team of experts creating wellness solutions for healthcare providers. Their dedicated professionals in legal, healthcare, and software fields develop innovative tools to support organizations in delivering better care.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

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Total amount:30

Most Funded Startups in Indianapolis for 2025

The top three most funded startups in Indianapolis have raised total funding of more than USD 369M. Sanctuary Wealth has 0.57% more funding than Appirio.
SB Score:422

Sanctuary Wealth empowers elite advisors with an innovative platform designed for entrepreneurial-minded professionals. It enables them to build and manage their practices with advanced tools, fostering growth and success in a competitive landscape.

Industry:
Fintech
Subindustry:
Financial Services

National Rank (United States)

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SB Score:443

Appirio accelerates the cloud-powered business, helping enterprises achieve real results from cloud applications and platforms like salesforce.com, Google and Workday. Appirio has worked with more than 500 enterprise customers including organizations like City of Los Angeles, Facebook, Flextronics, Home Depot, International Hotels Group, Japan Post Network, Ltd., L'Oreal, NetApp, NYU, Starbucks, Thomson Reuters and VMware. Appirio's technology-enabled professional services are supported by a team of nearly 500 cloud experts and CloudSpokes (www.cloudspokes.com), a more than 70,000 person-strong global cloud developer community. The company's expertise and innovative brokerage technology have been recognized by organizations such as the World Economic Forum, Bloomberg BusinessWeek, InformationWeek, Gartner, and IDC. Appirio has offices in the U.S., Europe and Japan, and is backed by Sequoia Capital, GGV Capital and General Atlantic.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

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SB Score:370

Cityscape Residential is a real estate development and construction company specializing in creating vibrant multifamily communities. They offer full-service solutions to bring high-quality living spaces to life.

Industry:
Ecommerce & Retail
Subindustry:
Proptech

National Rank (United States)

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Total amount:239

Top Hiring Startups in Indianapolis by Employee Number

The top three hiring startups in Indianapolis have an median employee size that is between [5001-10000]
SB Score:536

Empowering successful in-person, virtual, and hybrid events. A versatile solution for all event formats, ensuring seamless execution and maximum impact.

Industry:
Marketing & Sales
Subindustry:
Events

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

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Community Health Network is a nonprofit health system that facilitates specialty and acute care hospitals, surgery centers, home care services, and behavioral and employer health services. Its health services focus on breast and cancer care, diet and nutrition, digestive health, fertility and home care, genetic testing and counselling, medical imaging, mental and behavioral health, neuroscience, and more. Community Health Network offers an online platform that enables its customers to find information and book the services of doctors, and pay bills. It also provides its customers with financial assistance. Community Health Network was founded in 1956 and is based in Indianapolis, Indiana.

Industry:
Social & Leisure
Subindustry:
Communities

National Rank (United States)

0

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Regional Rank (North America)

0

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SB Score:644

Anagin is creating innovative treatments for neuropsychiatric conditions, targeting root causes with minimal side effects. Their goal is to revolutionize therapy options for these disorders.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:443

Appirio accelerates the cloud-powered business, helping enterprises achieve real results from cloud applications and platforms like salesforce.com, Google and Workday. Appirio has worked with more than 500 enterprise customers including organizations like City of Los Angeles, Facebook, Flextronics, Home Depot, International Hotels Group, Japan Post Network, Ltd., L'Oreal, NetApp, NYU, Starbucks, Thomson Reuters and VMware. Appirio's technology-enabled professional services are supported by a team of nearly 500 cloud experts and CloudSpokes (www.cloudspokes.com), a more than 70,000 person-strong global cloud developer community. The company's expertise and innovative brokerage technology have been recognized by organizations such as the World Economic Forum, Bloomberg BusinessWeek, InformationWeek, Gartner, and IDC. Appirio has offices in the U.S., Europe and Japan, and is backed by Sequoia Capital, GGV Capital and General Atlantic.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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Total amount:239

Explore the Startup Ecosystem of Indianapolis

National Rank

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Regional Rank

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44th

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Global Rank

(WorldWide)

110th

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Top Cities for Startups in United States - Ranked by StartupBlink

StartupBlink ranks the startup ecosystems of more than 100 countries and 1,000 cities. Download our latest Global Startup Ecosystem Report.
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2024 National Rank CityGlobal Rank
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Total Score

Access subscores for 1000 cities and 100 countries

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Quantity Score
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Quality Score
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Business Score
1st
0
1st
0
710.966
00.00
00.00
00.00
2nd
0
2nd
0
251.377
00.00
00.00
00.00
3rd
0
4th
0
121.937
00.00
00.00
00.00
4th
0
5th
0
109.679
00.00
00.00
00.00
5th
0
12th
0
52.052
00.00
00.00
00.00
6th
0
15th
0
42.256
00.00
00.00
00.00
7th
+
1
17th
+
4
41.259
00.00
00.00
00.00
8th
-
1
19th
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1
37.971
00.00
00.00
00.00
9th
0
24th
-
2
34.098
00.00
00.00
00.00
10th
0
25th
+
1
33.768
00.00
00.00
00.00
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