63 Top startups in Greenville for January 2025

We rank 6AM City, Fuel3D and KIYATEC in Greenville along with 60 other startups based on an algorithm that scores startups based on total investment, employee count, and quarterly website traffic. Greenville ranks #208 globally and #63 in United States.

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Best Startups in Greenville for 2025

SB Score:518

6AM is creating a network of local media outlets with a focus on daily newsletters, designed to scale.

Industry:
Social & Leisure
Subindustry:
Digital Media

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SB Score:433

Fuel3D is a portable 3D scanning system that captures shapes and colors for various creative uses. Capture high-quality 3D images with ease and explore endless creative possibilities.

Industry:
Hardware & IoT
Subindustry:
3D Printing

National Rank (United States)

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SB Score:428

KIYATEC enhances in vitro models of human biology for improved research. They specialize in creating advanced, accurate models to better understand complex biological processes.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

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4th

Atom
SB Score:394

Atom boosts sales team efficiency by interacting with customers through popular messaging apps like WhatsApp, similar to Hubspot scoring.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

National Rank (United States)

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SB Score:383

Earnnest offers a digital platform for secure real estate money transfers, simplifying transactions.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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SB Score:377

Hook Security offers innovative cybersecurity training to help organizations identify and respond to security threats. Our goal is for everyone to recognize and combat technology manipulation.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

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7th

Base
SB Score:371

Base is a powerful SaaS platform designed to simplify executive assistants' daily tasks. It streamlines responsibilities, making work more efficient.

Industry:
Software & Data
Subindustry:
Apps

National Rank (United States)

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SB Score:369

Glytec provides insulin management software to healthcare providers, enhancing care quality and cost-effectiveness.

Industry:
Healthtech
Subindustry:
Health Care

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SB Score:341

SimpliPhy is a user-friendly cloud app that simplifies data management. It enables seamless collaboration and secure storage, making it easy for users to access and share files from anywhere.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

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SB Score:333

Bubble Paperâ„¢ creates innovative paper packaging solutions for industries, void fill, and cold chain needs. Their optimized products are designed to provide efficient and sustainable packaging options for businesses.

Industry:
Energy & Environment
Subindustry:
Cleantech

National Rank (United States)

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SB Score:332

Ribometrix develops small molecule drugs for human diseases, using a platform approach. Their innovative therapeutics aim to treat a variety of conditions, offering new hope for patients in need of effective treatments.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

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Regional Rank (North America)

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Total amount:63

Top 17 Software & Data Startups in Greenville for 2025

The top three Software & Data startups in Greenville have raised more than USD 21.6M. Greenville ranks #301 globally for the Software & Data industry.

1st

Atom
SB Score:394

Atom boosts sales team efficiency by interacting with customers through popular messaging apps like WhatsApp, similar to Hubspot scoring.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:383

Earnnest offers a digital platform for secure real estate money transfers, simplifying transactions.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:377

Hook Security offers innovative cybersecurity training to help organizations identify and respond to security threats. Our goal is for everyone to recognize and combat technology manipulation.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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Total amount:17

Top 13 Healthtech Startups in Greenville for 2025

The top three Healthtech startups in Greenville have raised more than USD 125M. Greenville ranks #171 globally for the Healthtech industry.
SB Score:428

KIYATEC enhances in vitro models of human biology for improved research. They specialize in creating advanced, accurate models to better understand complex biological processes.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:369

Glytec provides insulin management software to healthcare providers, enhancing care quality and cost-effectiveness.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:341

SimpliPhy is a user-friendly cloud app that simplifies data management. It enables seamless collaboration and secure storage, making it easy for users to access and share files from anywhere.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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Total amount:13

Top 5 Energy & Environment Startups in Greenville for 2025

The top three Energy & Environment startups in Greenville have raised more than USD 38.8M. Greenville ranks #148 globally for the Energy & Environment industry.
SB Score:333

Bubble Paperâ„¢ creates innovative paper packaging solutions for industries, void fill, and cold chain needs. Their optimized products are designed to provide efficient and sustainable packaging options for businesses.

Industry:
Energy & Environment
Subindustry:
Cleantech

National Rank (United States)

0

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Regional Rank (North America)

0

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SB Score:300

tForm utilizes cutting-edge Industry 4.0 technologies to create eco-friendly packaging solutions. Their innovative approach combines engineering expertise with environmental consciousness to deliver advanced packaging options for businesses.

Industry:
Energy & Environment
Subindustry:
Cleantech

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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Total amount:5

Most Funded Startups in Greenville for 2025

The top three most funded startups in Greenville have raised total funding of more than USD 125M. KIYATEC has 0.08% more funding than Ribometrix.
SB Score:428

KIYATEC enhances in vitro models of human biology for improved research. They specialize in creating advanced, accurate models to better understand complex biological processes.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

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Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

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SB Score:332

Ribometrix develops small molecule drugs for human diseases, using a platform approach. Their innovative therapeutics aim to treat a variety of conditions, offering new hope for patients in need of effective treatments.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

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SB Score:369

Glytec provides insulin management software to healthcare providers, enhancing care quality and cost-effectiveness.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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Total amount:63

Top Hiring Startups in Greenville by Employee Number

The top three hiring startups in Greenville have an median employee size that is between [51-100]
SB Score:154

aeCyberSolutions offers proven frameworks and tools for securing industrial control systems/operational technology (ICS/OT). Their advanced methodologies and technology provide reliable protection against cyber threats, ensuring the safety and efficiency of critical infrastructure.

Industry:
Software & Data
Subindustry:
Cybersecurity

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:518

6AM is creating a network of local media outlets with a focus on daily newsletters, designed to scale.

Industry:
Social & Leisure
Subindustry:
Digital Media

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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3rd

Atom
SB Score:394

Atom boosts sales team efficiency by interacting with customers through popular messaging apps like WhatsApp, similar to Hubspot scoring.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:369

Glytec provides insulin management software to healthcare providers, enhancing care quality and cost-effectiveness.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page

Total amount:63

Explore the Startup Ecosystem of Greenville

National Rank

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63rd

3

Regional Rank

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72nd

3

Global Rank

(WorldWide)

208th

12

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Quantity Score
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710.966
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251.377
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121.937
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109.679
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