65 Top startups in Greenville for April 2025

We rank 6AM City, Atom and Inveterate, Inc in Greenville along with 62 other startups based on an algorithm that scores startups based on total investment, employee count, and quarterly website traffic. Greenville startup ecosystem ranks #208 globally and #63 in United States.

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Best Startups in Greenville for 2025

SB Score:506

6AM is creating a network of local media outlets with a focus on daily newsletters, designed to scale.

Industry:
Social & Leisure
Subindustry:
Digital Media

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2nd

Atom
SB Score:414

Atom boosts sales team efficiency by interacting with customers through popular messaging apps like WhatsApp, similar to Hubspot scoring.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

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SB Score:412

Inveterate offers a seamless solution for eCommerce merchants to implement paid membership loyalty programs, primarily on the Shopify platform. This turnkey system enhances customer engagement and boosts retention, enabling businesses to easily create and manage rewarding experiences for their loyal customers.

Industry:
Ecommerce & Retail
Subindustry:
Ecommerce

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SB Score:377

Pixlmob offers a platform that connects photographers and videographers with skilled editors who enhance images and videos, boosting their quality and visibility. By streamlining the editing process, Pixlmob empowers creatives to focus on their craft while ensuring their work stands out.

Industry:
Social & Leisure
Subindustry:
Entertainment

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SB Score:376

Earnnest offers a digital platform for secure real estate money transfers, simplifying transactions.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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SB Score:346

Hook Security offers innovative cybersecurity training to help organizations identify and respond to security threats. Our goal is for everyone to recognize and combat technology manipulation.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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SB Score:338

KIYATEC enhances in vitro models of human biology for improved research. They specialize in creating advanced, accurate models to better understand complex biological processes.

Industry:
Healthtech
Subindustry:
Biotechnology

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8th

Base
SB Score:330

Assistants are instrumental to the growth of the world’s leading companies, startups, and everything in between – and Base is their support system. Through years of working with EAs, we deeply understand the pain points assistants face in their daily work – as well as the difficulties businesses experience when trying to hire and retain great EA talent. It’s our mission to digitize and modernize in this space, because assistants will never stop being problem solvers and strategic business partners.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

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SB Score:328

Fuel3D is a portable 3D scanning system that captures shapes and colors for various creative uses. Capture high-quality 3D images with ease and explore endless creative possibilities.

Industry:
Hardware & IoT
Subindustry:
3D Printing

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SB Score:321

Ribometrix develops small molecule drugs for human diseases, using a platform approach. Their innovative therapeutics aim to treat a variety of conditions, offering new hope for patients in need of effective treatments.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:318

WAVS Custom is a groundbreaking music tech company that utilizes patented mobile 3D scanning technology to create custom-fit earphones, ensuring an unparalleled audio experience tailored to each user's unique ear shape.

Industry:
Hardware & IoT
Subindustry:
3D Printing

National Rank (United States)

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Regional Rank (North America)

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Total amount:65

Top 17 Software & Data Startups in Greenville for 2025

The top three Software & Data startups in Greenville have raised more than USD 29.5M. Greenville startup ecosystem ranks #301 globally for the Software & Data industry.

1st

Atom
SB Score:414

Atom boosts sales team efficiency by interacting with customers through popular messaging apps like WhatsApp, similar to Hubspot scoring.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

National Rank (United States)

0

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Regional Rank (North America)

0

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SB Score:376

Earnnest offers a digital platform for secure real estate money transfers, simplifying transactions.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

0

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Regional Rank (North America)

0

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SB Score:346

Hook Security offers innovative cybersecurity training to help organizations identify and respond to security threats. Our goal is for everyone to recognize and combat technology manipulation.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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Total amount:17

Top 13 Healthtech Startups in Greenville for 2025

The top three Healthtech startups in Greenville have raised more than USD 138M. Greenville startup ecosystem ranks #171 globally for the Healthtech industry.
SB Score:338

KIYATEC enhances in vitro models of human biology for improved research. They specialize in creating advanced, accurate models to better understand complex biological processes.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

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Regional Rank (North America)

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Global Rank (WorldWide)

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SB Score:321

Ribometrix develops small molecule drugs for human diseases, using a platform approach. Their innovative therapeutics aim to treat a variety of conditions, offering new hope for patients in need of effective treatments.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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Total amount:13

Top 5 Energy & Environment Startups in Greenville for 2025

The top three Energy & Environment startups in Greenville have raised more than USD 41.9M. Greenville startup ecosystem ranks #148 globally for the Energy & Environment industry.
SB Score:282

Bubble Paper™ creates innovative paper packaging solutions for industries, void fill, and cold chain needs. Their optimized products are designed to provide efficient and sustainable packaging options for businesses.

Industry:
Energy & Environment
Subindustry:
Cleantech

National Rank (United States)

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Regional Rank (North America)

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SB Score:282

tForm utilizes cutting-edge Industry 4.0 technologies to create eco-friendly packaging solutions. Their innovative approach combines engineering expertise with environmental consciousness to deliver advanced packaging options for businesses.

Industry:
Energy & Environment
Subindustry:
Cleantech

National Rank (United States)

0

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Regional Rank (North America)

0

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Total amount:5

Most Funded Startups in Greenville for 2025

The top three most funded startups in Greenville have raised total funding of more than USD 173M. Fuel3D has 0.09% more funding than KIYATEC.
SB Score:328

Fuel3D is a portable 3D scanning system that captures shapes and colors for various creative uses. Capture high-quality 3D images with ease and explore endless creative possibilities.

Industry:
Hardware & IoT
Subindustry:
3D Printing

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:338

KIYATEC enhances in vitro models of human biology for improved research. They specialize in creating advanced, accurate models to better understand complex biological processes.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

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SB Score:321

Ribometrix develops small molecule drugs for human diseases, using a platform approach. Their innovative therapeutics aim to treat a variety of conditions, offering new hope for patients in need of effective treatments.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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Total amount:65

Top Hiring Startups in Greenville by Employee Number

The top three hiring startups in Greenville have an median employee size that is between [101-250]

1st

Atom
SB Score:414

Atom boosts sales team efficiency by interacting with customers through popular messaging apps like WhatsApp, similar to Hubspot scoring.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:137

aeCyberSolutions offers proven frameworks and tools for securing industrial control systems/operational technology (ICS/OT). Their advanced methodologies and technology provide reliable protection against cyber threats, ensuring the safety and efficiency of critical infrastructure.

Industry:
Software & Data
Subindustry:
Cybersecurity

National Rank (United States)

0

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Regional Rank (North America)

0

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SB Score:506

6AM is creating a network of local media outlets with a focus on daily newsletters, designed to scale.

Industry:
Social & Leisure
Subindustry:
Digital Media

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

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SB Score:312

Glytec provides insulin management software to healthcare providers, enhancing care quality and cost-effectiveness.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

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Total amount:65

Explore the Startup Ecosystem of Greenville

National Rank

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Regional Rank

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72nd

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Global Rank

(WorldWide)

208th

12

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Top Cities for Startups in United States - Ranked by StartupBlink

StartupBlink ranks the startup ecosystems of more than 100 countries and 1,000 cities. Download our latest Global Startup Ecosystem Report.
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Quantity Score
Quality ScoreBusiness Score
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710.966
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251.377
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121.937
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109.679
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