23 Top startups in Frederick for April 2025

We rank RoosterBio, Theradaptive and EDUsys Global in Frederick along with 20 other startups based on an algorithm that scores startups based on total investment, employee count, and quarterly website traffic. Frederick startup ecosystem ranks #497 globally and #144 in United States.

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Best Startups in Frederick for 2025

SB Score:375

RoosterBio provides affordable, high volume living cellular materials like Mesenchymal Stem Cells, making it easier and cheaper to incorporate biologics into various technologies. Their products simplify the process and accelerate the development of cell-based innovations for the future.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

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Regional Rank (North America)

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SB Score:345

Theradaptive is transforming the delivery of protein therapeutics by leveraging its platform technology to convert any protein into a material binding variant. This permits ultra-precise and controlled delivery and retention of protein therapeutics at specific sites within the body. This platform has allowed the company to create therapeutics in several clinical indications including spinal fusion, soft tissue repair, localized oncology treatment, cartilage repair, and several other regenerative medicine applications.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

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SB Score:344

EDUsys Global offers internationally recognized education courses, endorsed by prestigious institutions. Their training programs are designed to enhance skills and knowledge for individuals seeking global recognition in the field of education.

Industry:
Social & Leisure
Subindustry:
Sports

National Rank (United States)

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Regional Rank (North America)

0

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SB Score:319

Fugue keeps cloud infrastructure compliant with security policies, ensuring continuous adherence.

Industry:
Software & Data
Subindustry:
Cloud

National Rank (United States)

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Regional Rank (North America)

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SB Score:311

Akonni Biosystems develops genetic testing devices for accurate and quick analysis. Their innovative technology provides precise results, making genetic testing accessible and efficient for various applications.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

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Regional Rank (North America)

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Global Rank (WorldWide)

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SB Score:309

KnowledgeNet.ai delivers innovative knowledge intelligence solutions that transform organizational collaboration. By harnessing the power of intellectual capital, it enables businesses to connect, share, and utilize their collective expertise more effectively, driving greater efficiency and fostering a culture of continuous learning.

Industry:
General
Subindustry:
Select an Industry first...

National Rank (United States)

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Regional Rank (North America)

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SB Score:303

FESCO Energy provides reliable and durable electricity solutions. Their services ensure a stable and secure power supply for all customers.

Industry:
Energy & Environment
Subindustry:
Energy

National Rank (United States)

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Regional Rank (North America)

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SB Score:284

Veralox Therapeutics develops small molecule therapeutics that treat the underlying pathologies of thrombosis and type one diabetes. Based on an understanding of the molecular mechanisms of these diseases, these efforts will lead to new treatment paradigms and better outcomes for patients.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

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Regional Rank (North America)

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SB Score:282

BioFactura is a biopharmaceutical company specializing in research and manufacturing. They develop innovative medicines and treatments to improve healthcare.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

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Regional Rank (North America)

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SB Score:275

EXOsecure is a cybersecurity service harnessing the power of crowd, cloud, and community to protect your digital assets. With a focus on clarity and engagement, EXOsecure offers advanced protection in a concise and user-friendly manner.

Industry:
Hardware & IoT
Subindustry:
Hardware

National Rank (United States)

0

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Regional Rank (North America)

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Global Rank (WorldWide)

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11th

Tellor
SB Score:266

A decentralized Oracle for DeFi, providing secure and reliable data feeds for decentralized finance applications.

Industry:
Fintech
Subindustry:
Cryptocurrency

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

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Total amount:23

Top 10 Healthtech Startups in Frederick for 2025

The top three Healthtech startups in Frederick have raised more than USD 192M. Frederick startup ecosystem ranks #206 globally for the Healthtech industry.
SB Score:375

RoosterBio provides affordable, high volume living cellular materials like Mesenchymal Stem Cells, making it easier and cheaper to incorporate biologics into various technologies. Their products simplify the process and accelerate the development of cell-based innovations for the future.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:311

Akonni Biosystems develops genetic testing devices for accurate and quick analysis. Their innovative technology provides precise results, making genetic testing accessible and efficient for various applications.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:284

Veralox Therapeutics develops small molecule therapeutics that treat the underlying pathologies of thrombosis and type one diabetes. Based on an understanding of the molecular mechanisms of these diseases, these efforts will lead to new treatment paradigms and better outcomes for patients.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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Total amount:10

Top 5 Software & Data Startups in Frederick for 2025

The top three Software & Data startups in Frederick have raised more than USD 267M. Frederick startup ecosystem ranks among the top 10 locations in the world for startups in Software & Data, holding the falseth position.
SB Score:345

Theradaptive is transforming the delivery of protein therapeutics by leveraging its platform technology to convert any protein into a material binding variant. This permits ultra-precise and controlled delivery and retention of protein therapeutics at specific sites within the body. This platform has allowed the company to create therapeutics in several clinical indications including spinal fusion, soft tissue repair, localized oncology treatment, cartilage repair, and several other regenerative medicine applications.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:319

Fugue keeps cloud infrastructure compliant with security policies, ensuring continuous adherence.

Industry:
Software & Data
Subindustry:
Cloud

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:219

Datakwip's software identifies energy-saving opportunities in buildings, helping users reduce costs and environmental impact.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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Total amount:5

Top 3 Hardware & IoT Startups in Frederick for 2025

The top three Hardware & IoT startups in Frederick have raised more than USD 2.97M. Frederick startup ecosystem ranks among the top 10 locations in the world for startups in Hardware & IoT, holding the falseth position.
SB Score:275

EXOsecure is a cybersecurity service harnessing the power of crowd, cloud, and community to protect your digital assets. With a focus on clarity and engagement, EXOsecure offers advanced protection in a concise and user-friendly manner.

Industry:
Hardware & IoT
Subindustry:
Hardware

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:224

Nanobiofab accelerates nanomaterial research and development by offering innovative nanoprinting technologies and solutions. Additionally, it provides advanced artificial intelligence sensors designed for telemedicine and personalized healthcare, enhancing the efficiency and effectiveness of medical services.

Industry:
Hardware & IoT
Subindustry:
Hardware

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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Matet's Kitchen is a vibrant Filipino food brand that celebrates the rich flavors and traditions of the Philippines. Specializing in authentic recipes and high-quality ingredients, it offers a delightful culinary experience that brings the taste of home to every meal, connecting food lovers with the heart of Filipino cuisine.

Industry:
Hardware & IoT
Subindustry:
Manufacturing

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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Total amount:3

Most Funded Startups in Frederick for 2025

The top three most funded startups in Frederick have raised total funding of more than USD 365M. Fugue has 2.02% more funding than BioFactura.
SB Score:319

Fugue keeps cloud infrastructure compliant with security policies, ensuring continuous adherence.

Industry:
Software & Data
Subindustry:
Cloud

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:282

BioFactura is a biopharmaceutical company specializing in research and manufacturing. They develop innovative medicines and treatments to improve healthcare.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
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SB Score:375

RoosterBio provides affordable, high volume living cellular materials like Mesenchymal Stem Cells, making it easier and cheaper to incorporate biologics into various technologies. Their products simplify the process and accelerate the development of cell-based innovations for the future.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
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Total amount:23

Top Hiring Startups in Frederick by Employee Number

The top three hiring startups in Frederick have an median employee size that is between [51-100]
SB Score:375

RoosterBio provides affordable, high volume living cellular materials like Mesenchymal Stem Cells, making it easier and cheaper to incorporate biologics into various technologies. Their products simplify the process and accelerate the development of cell-based innovations for the future.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
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SB Score:344

EDUsys Global offers internationally recognized education courses, endorsed by prestigious institutions. Their training programs are designed to enhance skills and knowledge for individuals seeking global recognition in the field of education.

Industry:
Social & Leisure
Subindustry:
Sports

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
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SB Score:345

Theradaptive is transforming the delivery of protein therapeutics by leveraging its platform technology to convert any protein into a material binding variant. This permits ultra-precise and controlled delivery and retention of protein therapeutics at specific sites within the body. This platform has allowed the company to create therapeutics in several clinical indications including spinal fusion, soft tissue repair, localized oncology treatment, cartilage repair, and several other regenerative medicine applications.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:311

Akonni Biosystems develops genetic testing devices for accurate and quick analysis. Their innovative technology provides precise results, making genetic testing accessible and efficient for various applications.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page

Total amount:23

Explore the Startup Ecosystem of Frederick

National Rank

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Regional Rank

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163rd

18

Global Rank

(WorldWide)

497th

70

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Top Cities for Startups in United States - Ranked by StartupBlink

StartupBlink ranks the startup ecosystems of more than 100 countries and 1,000 cities. Download our latest Global Startup Ecosystem Report.
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2024 National Rank CityGlobal Rank
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Total Score

Access subscores for 1000 cities and 100 countries

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Quantity Score
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Quality Score
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Business Score
1st
0
1st
0
710.966
00.00
00.00
00.00
2nd
0
2nd
0
251.377
00.00
00.00
00.00
3rd
0
4th
0
121.937
00.00
00.00
00.00
4th
0
5th
0
109.679
00.00
00.00
00.00
5th
0
12th
0
52.052
00.00
00.00
00.00
6th
0
15th
0
42.256
00.00
00.00
00.00
7th
+
1
17th
+
4
41.259
00.00
00.00
00.00
8th
-
1
19th
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1
37.971
00.00
00.00
00.00
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0
24th
-
2
34.098
00.00
00.00
00.00
10th
0
25th
+
1
33.768
00.00
00.00
00.00
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