24 Top startups in Evanston for April 2025

We rank Synapse Health, BloXroute Labs and Legacy.com in Evanston along with 21 other startups based on an algorithm that scores startups based on total investment, employee count, and quarterly website traffic. Evanston is part of Chicago startup ecosystem which ranks #15 globally and #6 in North America.

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Best Startups in Evanston for 2025

SB Score:437

Synapse Health streamlines the medical supply ordering process for patients, providers, and health plans, aiming to reduce costs and enhance efficiency. Specializing in medical devices and healthcare solutions, it simplifies access to essential personal health products, making healthcare more accessible for everyone involved.

Industry:
Healthtech
Subindustry:
Health Care

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SB Score:426

BloXroute is a blockchain distribution network that helps in scaling blockchains to thousands of transactions/second on-chain. The company's platform utilizes a global network of servers optimized for network performance using compression, encryption, and advanced networking techniques, propagates transactions and blocks faster, enabling clients to make the propagation of data more efficient, resulting in increased transaction throughput.

Industry:
Fintech
Subindustry:
Blockchain

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SB Score:422

Founded in 1998, Legacy.com is an innovative technology company that is the online leader in the memorial and obituary market. As the leader in the online memorial and obituary market, Legacy.com draws more than 18 million unique visitors each month, making it one of the 50 most visited websites in the U.S. In addition to hosting more than 20 million obituaries, Legacy.com also provides newspapers with online solutions for their celebration, pet and public notice categories. Legacy.com is headquartered in Evanston, Illinois, with information technology facilities in nearby Naperville, Illinois. The U.K. and European markets are supported through their London office. In Europe, they also manage iAnnounce, whose parent company, Web Announcements Ltd., was acquired by Legacy.com in 2013. Legacy.com is a privately held company.

Industry:
Social & Leisure
Subindustry:
Entertainment

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SB Score:417

BriteCo, a startup based in Evanston, IL, provides innovative insurance technology solutions. They offer a streamlined and user-friendly platform for individuals looking to protect their valuables.

Industry:
Fintech
Subindustry:
Insurance

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SB Score:402

Everspring creates interactive online and hybrid courses that break free from traditional limitations, offering engaging learning experiences.

Industry:
Edtech
Subindustry:
Edtech

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SB Score:334

Pinch is an on-demand cosmetic injection platform that connects users with medically trained nurse practitioners for convenient, private consultations and procedures. Whether at home, the office, or a hotel, Pinch simplifies the scheduling and booking process for cosmetic treatments tailored to individual needs.

Industry:
Ecommerce & Retail
Subindustry:
Consumer Goods

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SB Score:326

Naurex Inc. is a clinical-stage company developing novel therapies for depression and other CNS disorders based on a new mechanism of action for modulating the N-methyl-D-aspartic acid receptor (NMDAR). Using these discoveries, Naurex researchers have generated novel chemical drug classes known as glycine-site functional partial agonists (GFPAs), which modulate the receptor in a different way than existing NMDAR agents. The company's drug development programs based on its GFPA NMDAR modulators include the first-generation molecule, GLYX-13, the second-generation NRX-1050 small molecule series and additional compounds from Naurex's platform of novel NMDAR modulators.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:273

Sifter is a revolutionary app and website that helps users find products tailored to their wellness needs. Discover and explore items that align with your personal preferences for a healthier lifestyle.

Industry:
Ecommerce & Retail
Subindustry:
Ecommerce

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SB Score:263

Milu Health leverages electronic health records, claims, and pricing data to identify opportunities for reducing healthcare costs, enabling providers and patients to make informed decisions that optimize spending and enhance care efficiency.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

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Regional Rank (North America)

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Minute Molecular Diagnostics is a pioneering company founded in 2017 as a spinout from Northwestern University's Center for Innovation in Global Health Technology. It develops rapid immunoassay devices that enable swift and accurate molecular diagnostics, enhancing healthcare outcomes through innovative testing solutions.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:221

Springrose is a social enterprise focusing on ethically sourced labor, sustainability, and creating comfortable intimates for women. The majority of revenue is reinvested to support these initiatives.

Industry:
Ecommerce & Retail
Subindustry:
Ecommerce & Retail-Other

National Rank (United States)

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Regional Rank (North America)

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Total amount:24

Top 6 Software & Data Startups in Evanston for 2025

The top three Software & Data startups in Evanston have raised more than USD 225K. Evanston is part of Chicago startup ecosystem which ranks #14 globally for the Software & Data industry.
SB Score:171

ForgeWorks is an Evanston-based company founded in 2015 that offers a digital solution platform for civic innovators to design solutions.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

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Regional Rank (North America)

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SB Score:119

Acquirent, LLC. provides outsourced sales solutions for businesses of all kinds. Acquirent's process involves recruiting, training, and managing sales professionals. For more information, contact them today to learn how you can outsource your company's sales function.

Industry:
Software & Data
Subindustry:
Software and Data-Other

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SB Score:73

CartoFront is a groundbreaking search engine designed to revolutionize the way users discover residential and commercial real estate opportunities. By leveraging advanced technology, it enables users to seamlessly explore, compare, and evaluate various properties, streamlining the search process for their ideal real estate investments.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

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Regional Rank (North America)

0

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Global Rank (WorldWide)

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Total amount:6

Top 4 Ecommerce & Retail Startups in Evanston for 2025

The top three Ecommerce & Retail startups in Evanston have raised more than USD 13.6M. Evanston is part of Chicago startup ecosystem which ranks #15 globally for the Ecommerce & Retail industry.
SB Score:334

Pinch is an on-demand cosmetic injection platform that connects users with medically trained nurse practitioners for convenient, private consultations and procedures. Whether at home, the office, or a hotel, Pinch simplifies the scheduling and booking process for cosmetic treatments tailored to individual needs.

Industry:
Ecommerce & Retail
Subindustry:
Consumer Goods

National Rank (United States)

0

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Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

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SB Score:273

Sifter is a revolutionary app and website that helps users find products tailored to their wellness needs. Discover and explore items that align with your personal preferences for a healthier lifestyle.

Industry:
Ecommerce & Retail
Subindustry:
Ecommerce

National Rank (United States)

0

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Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

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SB Score:221

Springrose is a social enterprise focusing on ethically sourced labor, sustainability, and creating comfortable intimates for women. The majority of revenue is reinvested to support these initiatives.

Industry:
Ecommerce & Retail
Subindustry:
Ecommerce & Retail-Other

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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Total amount:4

Top 4 Fintech Startups in Evanston for 2025

The top three Fintech startups in Evanston have raised more than USD 270M. Evanston is part of Chicago startup ecosystem which ranks #18 globally for the Fintech industry.
SB Score:426

BloXroute is a blockchain distribution network that helps in scaling blockchains to thousands of transactions/second on-chain. The company's platform utilizes a global network of servers optimized for network performance using compression, encryption, and advanced networking techniques, propagates transactions and blocks faster, enabling clients to make the propagation of data more efficient, resulting in increased transaction throughput.

Industry:
Fintech
Subindustry:
Blockchain

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:417

BriteCo, a startup based in Evanston, IL, provides innovative insurance technology solutions. They offer a streamlined and user-friendly platform for individuals looking to protect their valuables.

Industry:
Fintech
Subindustry:
Insurance

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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Fidus Investment Corporation specializes in leveraged buyouts and refinancing for businesses. Their focus is on providing financial support for companies looking to grow and expand. With a strong track record in business development, Fidus Investment Corporation is a trusted partner for companies seeking strategic financial solutions.

Industry:
Fintech
Subindustry:
Fintech-Other

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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Total amount:4

Most Funded Startups in Evanston for 2025

The top three most funded startups in Evanston have raised total funding of more than USD 483M. BloXroute Labs has 0.61% more funding than Naurex.
SB Score:426

BloXroute is a blockchain distribution network that helps in scaling blockchains to thousands of transactions/second on-chain. The company's platform utilizes a global network of servers optimized for network performance using compression, encryption, and advanced networking techniques, propagates transactions and blocks faster, enabling clients to make the propagation of data more efficient, resulting in increased transaction throughput.

Industry:
Fintech
Subindustry:
Blockchain

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:326

Naurex Inc. is a clinical-stage company developing novel therapies for depression and other CNS disorders based on a new mechanism of action for modulating the N-methyl-D-aspartic acid receptor (NMDAR). Using these discoveries, Naurex researchers have generated novel chemical drug classes known as glycine-site functional partial agonists (GFPAs), which modulate the receptor in a different way than existing NMDAR agents. The company's drug development programs based on its GFPA NMDAR modulators include the first-generation molecule, GLYX-13, the second-generation NRX-1050 small molecule series and additional compounds from Naurex's platform of novel NMDAR modulators.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:402

Everspring creates interactive online and hybrid courses that break free from traditional limitations, offering engaging learning experiences.

Industry:
Edtech
Subindustry:
Edtech

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

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Total amount:24

Top Hiring Startups in Evanston by Employee Number

The top three hiring startups in Evanston have an median employee size that is between [251-500]
SB Score:402

Everspring creates interactive online and hybrid courses that break free from traditional limitations, offering engaging learning experiences.

Industry:
Edtech
Subindustry:
Edtech

National Rank (United States)

0

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Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

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Fidus Investment Corporation specializes in leveraged buyouts and refinancing for businesses. Their focus is on providing financial support for companies looking to grow and expand. With a strong track record in business development, Fidus Investment Corporation is a trusted partner for companies seeking strategic financial solutions.

Industry:
Fintech
Subindustry:
Fintech-Other

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:422

Founded in 1998, Legacy.com is an innovative technology company that is the online leader in the memorial and obituary market. As the leader in the online memorial and obituary market, Legacy.com draws more than 18 million unique visitors each month, making it one of the 50 most visited websites in the U.S. In addition to hosting more than 20 million obituaries, Legacy.com also provides newspapers with online solutions for their celebration, pet and public notice categories. Legacy.com is headquartered in Evanston, Illinois, with information technology facilities in nearby Naperville, Illinois. The U.K. and European markets are supported through their London office. In Europe, they also manage iAnnounce, whose parent company, Web Announcements Ltd., was acquired by Legacy.com in 2013. Legacy.com is a privately held company.

Industry:
Social & Leisure
Subindustry:
Entertainment

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:437

Synapse Health streamlines the medical supply ordering process for patients, providers, and health plans, aiming to reduce costs and enhance efficiency. Specializing in medical devices and healthcare solutions, it simplifies access to essential personal health products, making healthcare more accessible for everyone involved.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

0

View

Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

Browse
View full page

Total amount:24

Explore the Startup Ecosystem of Evanston

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Regional Rank

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Global Rank

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Top Cities for Startups in United States - Ranked by StartupBlink

StartupBlink ranks the startup ecosystems of more than 100 countries and 1,000 cities. Download our latest Global Startup Ecosystem Report.
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2024 National Rank CityGlobal Rank
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Total Score

Access subscores for 1000 cities and 100 countries

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Quantity Score
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Quality Score
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Business Score
1st
0
1st
0
710.966
00.00
00.00
00.00
2nd
0
2nd
0
251.377
00.00
00.00
00.00
3rd
0
4th
0
121.937
00.00
00.00
00.00
4th
0
5th
0
109.679
00.00
00.00
00.00
5th
0
12th
0
52.052
00.00
00.00
00.00
6th
0
15th
0
42.256
00.00
00.00
00.00
7th
+
1
17th
+
4
41.259
00.00
00.00
00.00
8th
-
1
19th
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1
37.971
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00.00
00.00
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0
24th
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2
34.098
00.00
00.00
00.00
10th
0
25th
+
1
33.768
00.00
00.00
00.00
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