236 Top startups in Durham for April 2025

We rank ServiceTrade, Wolfspeed and ProcessMaker in Durham along with 233 other startups based on an algorithm that scores startups based on total investment, employee count, and quarterly website traffic. Durham is part of Raleigh Durham startup ecosystem which ranks #41 globally and #18 in North America.

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Best Startups in Durham for 2025

SB Score:556

ServiceTrade provides mobile and web apps for maintenance businesses to increase service calls and improve customer communication.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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SB Score:521

Wolfspeed pioneers LED lighting and semiconductor solutions for wireless and power applications, driving innovation in the industry.

Industry:
Energy & Environment
Subindustry:
Energy

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SB Score:507

ProcessMaker Inc. creates the ProcessMaker Workflow & BPM software suite, empowering businesses to streamline processes efficiently.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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SB Score:500

Teamworks is a dynamic platform for sports organizations to streamline communication and operations. It enhances team collaboration and efficiency, making it easier for athletes, coaches, and staff to stay connected and organized.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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SB Score:463

Validic is a technology platform that offers digital health and remote care programs for healthcare organizations. It connects to over 400 in-home clinical and mobile health devices and applications. The company's mission is to improve the quality of human life by building technology that makes personal data actionable.

Industry:
Software & Data
Subindustry:
Apps

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SB Score:462

Get Spiffy is an on-demand car wash and detailing service. A team of experienced Triangle, NC entrepreneurs are building the World's first on-demand smartphone-powered technology-enabled mobile car wash and detailing service. The app is used for both communication and payment. Additionally, Spiffy is highly concerned about the environment, and all of its washes are eco-friendly.

Industry:
Software & Data
Subindustry:
Apps

National Rank (United States)

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SB Score:461

Metabolon pioneers metabolomics-based biomarker discovery through innovative analytical methods and software, enabling cutting-edge research in personalized medicine and precision health.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

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SB Score:455

Alcove is a vibrant shared living community that offers individual room leases in beautifully furnished homes. Their innovative technology matches residents with ideal bedrooms while providing essential amenities like Wi-Fi, utilities, housekeeping, and engaging community events, creating a seamless and enriching living experience.

Industry:
Ecommerce & Retail
Subindustry:
Proptech

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SB Score:452

FoodLogiQ offers software for tracing food, ensuring safety, enhancing sustainability, and providing transparency in the supply chain.

Industry:
Software & Data
Subindustry:
Apps

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SB Score:451

Spreedly offers a solution for businesses needing to work with multiple payment gateways. Store credit cards securely in the cloud, saving on PCI compliance costs. Easily integrate with 50 different payment gateways using one API. Ideal for global transactions with local processing or customer-provided merchant accounts. Start building the next big platform with Spreedly.

Industry:
Software & Data
Subindustry:
SaaS

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SB Score:449

restor3d empowers surgeons with 3D printed implants for enhanced body reconstruction. Revolutionizing medical procedures, this startup improves surgical outcomes and patient recovery.

Industry:
Hardware & IoT
Subindustry:
3D Printing

National Rank (United States)

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Regional Rank (North America)

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Total amount:236

Top 12 Social & Leisure Startups in Durham for 2025

The top three Social & Leisure startups in Durham have raised more than USD 82.5M. Durham is part of Raleigh Durham startup ecosystem which ranks #8 globally for the Social & Leisure industry.
SB Score:440

GoTriangle is a collaborative effort of public transportation agencies in the Triangle region. Their mission is to enhance commuter benefits and promote sustainable transportation options.

Industry:
Social & Leisure
Subindustry:
Communities

National Rank (United States)

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Regional Rank (North America)

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SB Score:363

Sportvision, Inc. is the premier innovator of sports and entertainment products for fans, media and marketers. Sportvision is a privately held corporation whose solutions have enhanced experiences for fans, media and marketing partners of the NFL, NBA, NASCAR, NHL, PGA TOUR, LPGA Tour, Major League Baseball, NCAA football and basketball, WTA, Major League Soccer and other sporting events on-air and online. The company has captured ten Emmy Awards for its products, including three for its signature broadcast enhancements, the iconic virtual yellow 1st & Ten® line and K-Zone™. We were voted one of the World’s Top 50 Most Innovative Companies in 2010 by Fast Company.

Industry:
Social & Leisure
Subindustry:
Entertainment

National Rank (United States)

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Regional Rank (North America)

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Total amount:12

Top 81 Healthtech Startups in Durham for 2025

The top three Healthtech startups in Durham have raised more than USD 905M. Durham is part of Raleigh Durham startup ecosystem which ranks #15 globally for the Healthtech industry.
SB Score:461

Metabolon pioneers metabolomics-based biomarker discovery through innovative analytical methods and software, enabling cutting-edge research in personalized medicine and precision health.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

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Regional Rank (North America)

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SB Score:430

Precision BioSciences is a biotechnology company dedicated to improving lives through its next-generation gene editing technology, ARCUS. Precision BioSciences’ mission is to translate the world’s most powerful genome editing technology into greatly needed products throughout the life sciences. Precision’s proprietary ARCUS genome editing technology enables the production of highly specific nucleases that can insert, remove, and modify DNA at essentially any location in a complex genome.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

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Regional Rank (North America)

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SB Score:417

BioSkryb Genomics is an innovative organization revolutionizing single-cell molecular discovery and analysis. By leveraging cutting-edge technology, it enables researchers to unlock intricate biological insights, driving advancements in genomics and personalized medicine.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

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Regional Rank (North America)

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Global Rank (WorldWide)

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Total amount:81

Top 61 Software & Data Startups in Durham for 2025

The top three Software & Data startups in Durham have raised more than USD 643M. Durham is part of Raleigh Durham startup ecosystem which ranks #49 globally for the Software & Data industry.
SB Score:556

ServiceTrade provides mobile and web apps for maintenance businesses to increase service calls and improve customer communication.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

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SB Score:507

ProcessMaker Inc. creates the ProcessMaker Workflow & BPM software suite, empowering businesses to streamline processes efficiently.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:500

Teamworks is a dynamic platform for sports organizations to streamline communication and operations. It enhances team collaboration and efficiency, making it easier for athletes, coaches, and staff to stay connected and organized.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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Total amount:61

Most Funded Startups in Durham for 2025

The top three most funded startups in Durham have raised total funding of more than USD 1.37B. Metabolon has 0.15% more funding than Phononic.
SB Score:461

Metabolon pioneers metabolomics-based biomarker discovery through innovative analytical methods and software, enabling cutting-edge research in personalized medicine and precision health.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

0

View

Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:436

Phononic creates innovative thermoelectric chips as an eco-friendly alternative to traditional refrigeration methods, replacing compressor technology.

Industry:
Hardware & IoT
Subindustry:
Hardware

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:462

Get Spiffy is an on-demand car wash and detailing service. A team of experienced Triangle, NC entrepreneurs are building the World's first on-demand smartphone-powered technology-enabled mobile car wash and detailing service. The app is used for both communication and payment. Additionally, Spiffy is highly concerned about the environment, and all of its washes are eco-friendly.

Industry:
Software & Data
Subindustry:
Apps

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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Total amount:236

Top Hiring Startups in Durham by Employee Number

The top three hiring startups in Durham have an median employee size that is between [501-1000]
SB Score:521

Wolfspeed pioneers LED lighting and semiconductor solutions for wireless and power applications, driving innovation in the industry.

Industry:
Energy & Environment
Subindustry:
Energy

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:363

Sportvision, Inc. is the premier innovator of sports and entertainment products for fans, media and marketers. Sportvision is a privately held corporation whose solutions have enhanced experiences for fans, media and marketing partners of the NFL, NBA, NASCAR, NHL, PGA TOUR, LPGA Tour, Major League Baseball, NCAA football and basketball, WTA, Major League Soccer and other sporting events on-air and online. The company has captured ten Emmy Awards for its products, including three for its signature broadcast enhancements, the iconic virtual yellow 1st & Ten® line and K-Zone™. We were voted one of the World’s Top 50 Most Innovative Companies in 2010 by Fast Company.

Industry:
Social & Leisure
Subindustry:
Entertainment

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:313

ArchiveSocial is the top choice for government agencies and school districts looking to archive social media content for compliance and risk management. Stay safe and organized with our leading solution for social media archiving.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:500

Teamworks is a dynamic platform for sports organizations to streamline communication and operations. It enhances team collaboration and efficiency, making it easier for athletes, coaches, and staff to stay connected and organized.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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Total amount:236

Explore the Startup Ecosystem of Durham

National Rank

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Regional Rank

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18th

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Global Rank

(WorldWide)

41st

2

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Quality ScoreBusiness Score
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710.966
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251.377
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121.937
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109.679
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