195 Top startups in Cleveland for April 2025

We rank OnShift, Splash Financial and SPR Therapeutics in Cleveland along with 192 other startups based on an algorithm that scores startups based on total investment, employee count, and quarterly website traffic. Cleveland startup ecosystem ranks #124 globally and #43 in United States.

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Top Unicorn Startups in Cleveland for 2025

Keyfactor is the only unicorn in Cleveland raising more than USD 1.3B. It is the undefined ranked unicorn in North America.
SB Score:443

Keyfactor develops and maintains cybersecurity solutions to ensure safe online transactions for international enterprises.

Industry:
Software & Data
Subindustry:
Cybersecurity

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Best Startups in Cleveland for 2025

SB Score:548

OnShift offers healthcare organizations cloud-based software and services to streamline workforce management. With proactive solutions, they help solve daily staffing challenges, making operations more efficient and effective.

Industry:
Software & Data
Subindustry:
Cloud

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SB Score:492

Splash Financial''s mission is to make people more powerful than their debt. To that end, Splash helps borrowers easily shop and compare financial products from a Splash-powered network of credit unions and bank partners. Splash’s unique hybrid marketplace model and automated underwriting platform has helped the average person refinancing their student loans save thousands. Splash has raised over $60 million in venture capital from leading investors including DST Global, Citi Ventures, Detroit Venture Partners, CMFG Ventures and Northwestern Mutual Future Ventures.

Industry:
Edtech
Subindustry:
Education-Other

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SB Score:481

SPR Therapeutics develops peripheral nerve stimulation devices for pain management, providing clinicians with innovative solutions for treating patients.

Industry:
Healthtech
Subindustry:
Health Care

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SB Score:466

80 Acres Farms utilizes cutting-edge indoor farming technology to cultivate crops efficiently. Their innovative approach ensures high-quality produce while minimizing environmental impact.

Industry:
Foodtech
Subindustry:
Agtech

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SB Score:451

Cleveland HeartLab, Inc. is a specialty clinical laboratory and disease management company focused on novel biomarker technologies and the creation of proprietary diagnostic tests.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:441

BoxCast offers comprehensive video-streaming solutions for businesses, providing a seamless experience from start to finish. With BoxCast, organizations can easily stream their content online, reaching a wider audience and maximizing engagement.

Industry:
Social & Leisure
Subindustry:
Sports

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FuseBase, nominated as Product of the Year by Product Hunt in the team collaboration category, empowers teams to streamline communication and enhance productivity. In December 2023, it achieved remarkable recognition as the #1 product of the day, week, and month, showcasing its impact and popularity among users.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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Midwest Shooting Center offers a safe and enjoyable shooting experience for firearms enthusiasts. With top-notch facilities and expert staff, visitors can sharpen their marksmanship skills and have a blast in a welcoming environment.

Industry:
Social & Leisure
Subindustry:
Sports

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SB Score:406

Within3 is revolutionizing healthcare with a secure platform connecting practitioners, institutions, and pharmaceutical companies worldwide. Our products improve collaboration and ultimately lead to better patient outcomes.

Industry:
Healthtech
Subindustry:
Medtech

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10th

BIOHM
SB Score:405

BIOHM is a pioneering microbiome company that focuses on the essential role of fungi in digestive health. With over 20 years of NIH-supported research, it offers a range of whole probiotics and gut microbiome testing, empowering individuals to optimize their digestive wellness.

Industry:
Healthtech
Subindustry:
Health Care

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SB Score:396

Complion provides clinical research sites with an eRegulatory solution. Streamline regulatory processes and enhance compliance with this innovative platform.

Industry:
Healthtech
Subindustry:
Health Care

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Total amount:195

Top 61 Software & Data Startups in Cleveland for 2025

The top three Software & Data startups in Cleveland have raised more than USD 150M. Cleveland startup ecosystem ranks #116 globally for the Software & Data industry.
SB Score:548

OnShift offers healthcare organizations cloud-based software and services to streamline workforce management. With proactive solutions, they help solve daily staffing challenges, making operations more efficient and effective.

Industry:
Software & Data
Subindustry:
Cloud

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FuseBase, nominated as Product of the Year by Product Hunt in the team collaboration category, empowers teams to streamline communication and enhance productivity. In December 2023, it achieved remarkable recognition as the #1 product of the day, week, and month, showcasing its impact and popularity among users.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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SB Score:348

Axuall is a platform where users can securely store and manage their verified credentials from trusted sources. With Axuall, individuals can easily access and share their important documents, making identity verification a breeze.

Industry:
Software & Data
Subindustry:
Comtech

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Total amount:61

Top 36 Healthtech Startups in Cleveland for 2025

The top three Healthtech startups in Cleveland have raised more than USD 333M. Cleveland startup ecosystem ranks #68 globally for the Healthtech industry.
SB Score:481

SPR Therapeutics develops peripheral nerve stimulation devices for pain management, providing clinicians with innovative solutions for treating patients.

Industry:
Healthtech
Subindustry:
Health Care

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SB Score:451

Cleveland HeartLab, Inc. is a specialty clinical laboratory and disease management company focused on novel biomarker technologies and the creation of proprietary diagnostic tests.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

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SB Score:406

Within3 is revolutionizing healthcare with a secure platform connecting practitioners, institutions, and pharmaceutical companies worldwide. Our products improve collaboration and ultimately lead to better patient outcomes.

Industry:
Healthtech
Subindustry:
Medtech

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Total amount:36

Top 15 Fintech Startups in Cleveland for 2025

The top three Fintech startups in Cleveland have raised more than USD 85.7M. Cleveland startup ecosystem ranks #140 globally for the Fintech industry.
SB Score:322

Revolutionize car titling with an online platform offering enhanced security, efficiency for owners, state governments, and law enforcement. Experience streamlined processes and peace of mind with our innovative solution.

Industry:
Fintech
Subindustry:
Blockchain

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SB Score:288

24 Exchange offers a cutting-edge trading platform for professional quants and active traders. Easily trade multiple assets in one place, catering to advanced users seeking efficient and powerful trading tools.

Industry:
Fintech
Subindustry:
Financial Services

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3rd

Mezu
SB Score:281

The only money app that puts your privacy first. Give & Get Money, don’t share your personal information. It’s the Experience of Cash.

Industry:
Fintech
Subindustry:
Financial Technology

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Total amount:15

Most Funded Startups in Cleveland for 2025

The top three most funded startups in Cleveland have raised total funding of more than USD 605M. 80 Acres Farms has 1.65% more funding than Centerline Biomedical.
SB Score:466

80 Acres Farms utilizes cutting-edge indoor farming technology to cultivate crops efficiently. Their innovative approach ensures high-quality produce while minimizing environmental impact.

Industry:
Foodtech
Subindustry:
Agtech

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SB Score:367

Centerline Biomedical, a spin-off from Cleveland Clinic, is creating a cutting-edge system for medical procedures. Their innovative technology aims to improve accuracy and efficiency in healthcare, revolutionizing the way procedures are performed.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

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SB Score:481

SPR Therapeutics develops peripheral nerve stimulation devices for pain management, providing clinicians with innovative solutions for treating patients.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

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Total amount:195

Top Hiring Startups in Cleveland by Employee Number

The top three hiring startups in Cleveland have an median employee size that is between [501-1000]

GE Current, a Daintree company, uses LED technology, sensors, and software to help businesses and cities save energy. Their innovative solutions make it easy for commercial buildings, retail stores, and industrial facilities to operate more efficiently and sustainably.

Industry:
Energy & Environment
Subindustry:
Energy

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SB Score:335

Experienced spa and salon operator specializing in providing top-notch services. Offering a wide range of treatments in a luxurious and relaxing environment. Ensuring clients receive the highest level of care and pampering.

Industry:
Healthtech
Subindustry:
Life Sciences

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SB Score:466

80 Acres Farms utilizes cutting-edge indoor farming technology to cultivate crops efficiently. Their innovative approach ensures high-quality produce while minimizing environmental impact.

Industry:
Foodtech
Subindustry:
Agtech

National Rank (United States)

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0

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SB Score:406

Within3 is revolutionizing healthcare with a secure platform connecting practitioners, institutions, and pharmaceutical companies worldwide. Our products improve collaboration and ultimately lead to better patient outcomes.

Industry:
Healthtech
Subindustry:
Medtech

National Rank (United States)

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Total amount:195

Explore the Startup Ecosystem of Cleveland

National Rank

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Regional Rank

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49th

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Global Rank

(WorldWide)

124th

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Top Cities for Startups in United States - Ranked by StartupBlink

StartupBlink ranks the startup ecosystems of more than 100 countries and 1,000 cities. Download our latest Global Startup Ecosystem Report.
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Quantity Score
Quality ScoreBusiness Score
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710.966
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251.377
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121.937
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109.679
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