189 Top startups in Cleveland for January 2025

We rank OnShift, Fello and 80 Acres Farms in Cleveland along with 186 other startups based on an algorithm that scores startups based on total investment, employee count, and quarterly website traffic. Cleveland ranks #124 globally and #43 in United States.

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Accelerators

Top Unicorn Startups in Cleveland for 2025

Keyfactor is the only unicorn in Cleveland raising more than USD 1.3B. It is the undefined ranked unicorn in North America.
SB Score:474

Keyfactor develops and maintains cybersecurity solutions to ensure safe online transactions for international enterprises.

Industry:
Software & Data
Subindustry:
Cybersecurity

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Total amount:1

Best Startups in Cleveland for 2025

SB Score:561

OnShift offers healthcare organizations cloud-based software and services to streamline workforce management. With proactive solutions, they help solve daily staffing challenges, making operations more efficient and effective.

Industry:
Software & Data
Subindustry:
Cloud

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SB Score:485

Fello equips agents with an iBuying solution, offering home sellers a smooth, reliable experience.

Industry:
Ecommerce & Retail
Subindustry:
Marketplaces

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SB Score:470

80 Acres Farms utilizes cutting-edge indoor farming technology to cultivate crops efficiently. Their innovative approach ensures high-quality produce while minimizing environmental impact.

Industry:
Foodtech
Subindustry:
Agtech

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SB Score:469

BoxCast offers comprehensive video-streaming solutions for businesses, providing a seamless experience from start to finish. With BoxCast, organizations can easily stream their content online, reaching a wider audience and maximizing engagement.

Industry:
Social & Leisure
Subindustry:
Sports

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SB Score:469

Splash Financial empowers young professionals with financial education and student loan refinancing, providing them with greater financial flexibility.

Industry:
Fintech
Subindustry:
Fintech-Other

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Midwest Shooting Center offers a safe and enjoyable shooting experience for firearms enthusiasts. With top-notch facilities and expert staff, visitors can sharpen their marksmanship skills and have a blast in a welcoming environment.

Industry:
Social & Leisure
Subindustry:
Sports

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SB Score:454

SPR Therapeutics develops peripheral nerve stimulation devices for pain management, providing clinicians with innovative solutions for treating patients.

Industry:
Healthtech
Subindustry:
Health Care

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SB Score:433

Within3 is revolutionizing healthcare with a secure platform connecting practitioners, institutions, and pharmaceutical companies worldwide. Our products improve collaboration and ultimately lead to better patient outcomes.

Industry:
Healthtech
Subindustry:
Medtech

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FuseBase, nominated as Product of the Year by Product Hunt in the team collaboration category, empowers teams to streamline communication and enhance productivity. In December 2023, it achieved remarkable recognition as the #1 product of the day, week, and month, showcasing its impact and popularity among users.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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10th

BIOHM
SB Score:420

BIOHM is a pioneering microbiome company that focuses on the essential role of fungi in digestive health. With over 20 years of NIH-supported research, it offers a range of whole probiotics and gut microbiome testing, empowering individuals to optimize their digestive wellness.

Industry:
Healthtech
Subindustry:
Health Care

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SB Score:411

Get quick insights from key stakeholders with our platform. Connect directly to decision-makers for winning results in hours. Streamlined and efficient communication for better outcomes.

Industry:
Marketing & Sales
Subindustry:
Market Research

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Total amount:189

Top 59 Software & Data Startups in Cleveland for 2025

The top three Software & Data startups in Cleveland have raised more than USD 107M. Cleveland ranks #116 globally for the Software & Data industry.
SB Score:561

OnShift offers healthcare organizations cloud-based software and services to streamline workforce management. With proactive solutions, they help solve daily staffing challenges, making operations more efficient and effective.

Industry:
Software & Data
Subindustry:
Cloud

National Rank (United States)

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FuseBase, nominated as Product of the Year by Product Hunt in the team collaboration category, empowers teams to streamline communication and enhance productivity. In December 2023, it achieved remarkable recognition as the #1 product of the day, week, and month, showcasing its impact and popularity among users.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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SB Score:393

DecisionDeskā„¢ streamlines application processing with video automation for clients in New York, NY and Cleveland, OH. Simplify submission and review workflows for high volumes of applications.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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Total amount:59

Top 35 Healthtech Startups in Cleveland for 2025

The top three Healthtech startups in Cleveland have raised more than USD 250M. Cleveland ranks #68 globally for the Healthtech industry.
SB Score:454

SPR Therapeutics develops peripheral nerve stimulation devices for pain management, providing clinicians with innovative solutions for treating patients.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

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SB Score:433

Within3 is revolutionizing healthcare with a secure platform connecting practitioners, institutions, and pharmaceutical companies worldwide. Our products improve collaboration and ultimately lead to better patient outcomes.

Industry:
Healthtech
Subindustry:
Medtech

National Rank (United States)

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SB Score:420

BIOHM is a pioneering microbiome company that focuses on the essential role of fungi in digestive health. With over 20 years of NIH-supported research, it offers a range of whole probiotics and gut microbiome testing, empowering individuals to optimize their digestive wellness.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

0

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Total amount:35

Top 16 Fintech Startups in Cleveland for 2025

The top three Fintech startups in Cleveland have raised more than USD 132M. Cleveland ranks #140 globally for the Fintech industry.
SB Score:469

Splash Financial empowers young professionals with financial education and student loan refinancing, providing them with greater financial flexibility.

Industry:
Fintech
Subindustry:
Fintech-Other

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SB Score:364

Revolutionize car titling with an online platform offering enhanced security, efficiency for owners, state governments, and law enforcement. Experience streamlined processes and peace of mind with our innovative solution.

Industry:
Fintech
Subindustry:
Blockchain

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SB Score:352

VotemĀ® is a mobile voting platform on the blockchain, empowering global citizens to vote conveniently online.

Industry:
Fintech
Subindustry:
Blockchain

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Total amount:16

Most Funded Startups in Cleveland for 2025

The top three most funded startups in Cleveland have raised total funding of more than USD 425M. 80 Acres Farms has 0.91% more funding than SPR Therapeutics.
SB Score:470

80 Acres Farms utilizes cutting-edge indoor farming technology to cultivate crops efficiently. Their innovative approach ensures high-quality produce while minimizing environmental impact.

Industry:
Foodtech
Subindustry:
Agtech

National Rank (United States)

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SB Score:454

SPR Therapeutics develops peripheral nerve stimulation devices for pain management, providing clinicians with innovative solutions for treating patients.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (United States)

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Diasome Pharmaceuticals is a cutting-edge company creating innovative insulin treatments for diabetes. Their focus is on developing effective therapies to improve the lives of those living with this chronic condition.

Industry:
Healthtech
Subindustry:
Biotechnology

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Total amount:189

Top Hiring Startups in Cleveland by Employee Number

The top three hiring startups in Cleveland have an median employee size that is between [501-1000]

GE Current, a Daintree company, uses LED technology, sensors, and software to help businesses and cities save energy. Their innovative solutions make it easy for commercial buildings, retail stores, and industrial facilities to operate more efficiently and sustainably.

Industry:
Energy & Environment
Subindustry:
Energy

National Rank (United States)

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SB Score:394

Experienced spa and salon operator specializing in providing top-notch services. Offering a wide range of treatments in a luxurious and relaxing environment. Ensuring clients receive the highest level of care and pampering.

Industry:
Healthtech
Subindustry:
Life Sciences

National Rank (United States)

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SB Score:470

80 Acres Farms utilizes cutting-edge indoor farming technology to cultivate crops efficiently. Their innovative approach ensures high-quality produce while minimizing environmental impact.

Industry:
Foodtech
Subindustry:
Agtech

National Rank (United States)

0

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Regional Rank (North America)

0

View

Global Rank (WorldWide)

0

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SB Score:433

Within3 is revolutionizing healthcare with a secure platform connecting practitioners, institutions, and pharmaceutical companies worldwide. Our products improve collaboration and ultimately lead to better patient outcomes.

Industry:
Healthtech
Subindustry:
Medtech

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

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Total amount:189

Explore the Startup Ecosystem of Cleveland

National Rank

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43rd

1

Regional Rank

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49th

1

Global Rank

(WorldWide)

124th

4

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Quantity Score
Quality ScoreBusiness Score
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710.966
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251.377
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121.937
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109.679
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