40 Top startups in Aliso Viejo for April 2025

We rank indie Semiconductor, Vertos Medical and OrthAlign in Aliso Viejo along with 37 other startups based on an algorithm that scores startups based on total investment, employee count, and quarterly website traffic. Aliso Viejo is part of Los Angeles Area startup ecosystem which ranks #4 globally and #3 in North America.

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Best Startups in Aliso Viejo for 2025

SB Score:468

Indie is a tech company at the forefront of the autotech revolution, specializing in cutting-edge automotive semiconductors and software platforms.

Industry:
Transportation
Subindustry:
Automotive

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SB Score:432

Vertos Medical develops and sells innovative medical devices for treating spinal conditions. Their products are designed to address common spinal diseases, providing patients with effective treatment options.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:410

OrthAlign offers innovative medical devices for joint replacement patients, improving their quality of life with less pain.

Industry:
Healthtech
Subindustry:
Biotechnology

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SB Score:373

This innovative IT management and security solution seamlessly integrates Vulnerability Scanning, Patch Management, and EDR functionalities. Users can easily identify and address security vulnerabilities, manage patches effectively, and enhance endpoint security all in one platform.

Industry:
Software & Data
Subindustry:
Cloud

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SB Score:373

Spyglass Pharma is dedicated to developing innovative treatments for chronic eye diseases using advanced technology. The company aims to deliver a range of drugs targeting various ophthalmic conditions, striving to improve patient outcomes and enhance vision care.

Industry:
Software & Data
Subindustry:
Enterprise Technology

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SB Score:365

Gaikai (Gaikai Inc.) is a next generation video game technology company acquired by Sony Computer Entertainment (SCE) in 2012. Gaikai is powering SCE video game streaming services including Remote Play (between the PlayStation 4 and PlayStation Vita) and an upcoming cloud-based game streaming service (PlayStation Now). Gaikai is driven by a simple mission: make as many games available to as many people on as many devices as possible, easily and instantly. [Gaikai's Website](http://www.gaikai.com)

Industry:
Social & Leisure
Subindustry:
Gaming

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SB Score:361

Corent Technology offers SurPaaS, a platform for SaaS transformation and software delivery. Ideal for various companies, it streamlines processes and enhances efficiency.

Industry:
Software & Data
Subindustry:
Cloud

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SB Score:338

AWM Smart Shelf transforms the in-store shopping experience by seamlessly integrating online capabilities. It empowers retailers to enhance customer engagement, streamline inventory management, and provide personalized promotions, ultimately driving sales and improving customer satisfaction in physical marketplaces.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

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SB Score:336

Bright Uro develops cutting-edge diagnostic devices for Urology, combining advanced technology to provide clinicians with actionable insights. By leveraging hardware, software, and data science, they unlock new data streams to improve patient care.

Industry:
Healthtech
Subindustry:
Health Care

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SB Score:333

ThinkIQ develops a supply chain management cloud-based software designed to combine existing disparate and siloed supply chain data with modeling technology to detect material movements. Its software integrates advanced cloud, big data management, and time series historian technology to provide context for the data and correlate events over time to enable end-to-end granular supply chain visibility, allowing manufacturers and enterprises to generate significant financial savings and improve engagement with customers. The company was founded in 2015 and is headquartered in Aliso Viejo, California.

Industry:
Hardware & IoT
Subindustry:
Consumer Electronics

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Total amount:40

Top 14 Software & Data Startups in Aliso Viejo for 2025

The top three Software & Data startups in Aliso Viejo have raised more than USD 259M. Aliso Viejo is part of Los Angeles Area startup ecosystem which ranks #6 globally for the Software & Data industry.
SB Score:373

This innovative IT management and security solution seamlessly integrates Vulnerability Scanning, Patch Management, and EDR functionalities. Users can easily identify and address security vulnerabilities, manage patches effectively, and enhance endpoint security all in one platform.

Industry:
Software & Data
Subindustry:
Cloud

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SB Score:373

Spyglass Pharma is dedicated to developing innovative treatments for chronic eye diseases using advanced technology. The company aims to deliver a range of drugs targeting various ophthalmic conditions, striving to improve patient outcomes and enhance vision care.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

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SB Score:361

Corent Technology offers SurPaaS, a platform for SaaS transformation and software delivery. Ideal for various companies, it streamlines processes and enhances efficiency.

Industry:
Software & Data
Subindustry:
Cloud

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Total amount:14

Top 4 Ecommerce & Retail Startups in Aliso Viejo for 2025

The top three Ecommerce & Retail startups in Aliso Viejo have raised more than USD 550K. Aliso Viejo is part of Los Angeles Area startup ecosystem which ranks #3 globally for the Ecommerce & Retail industry.
SB Score:188

Visional is a cutting-edge platform and app that lets users explore and purchase products through livestream video. Discover and shop for your favorite items in real-time with ease.

Industry:
Ecommerce & Retail
Subindustry:
Ecommerce

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SB Score:53

Leadific is an innovative automation software that simplifies marketing processes by integrating essential systems. It empowers clients to streamline their operations, enabling them to focus on generating revenue through effective client acquisition without the burden of managing multiple platforms.

Industry:
Ecommerce & Retail
Subindustry:
Social Commerce

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SB Score:23

Develops discreet and effective pelvic floor exercise devices for women’s health.

Industry:
Ecommerce & Retail
Subindustry:
Consumer Goods

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Total amount:4

Top 2 Social & Leisure Startups in Aliso Viejo for 2025

The top three Social & Leisure startups in Aliso Viejo have raised more than USD 45M. Aliso Viejo is part of Los Angeles Area startup ecosystem which ranks #4 globally for the Social & Leisure industry.
SB Score:365

Gaikai (Gaikai Inc.) is a next generation video game technology company acquired by Sony Computer Entertainment (SCE) in 2012. Gaikai is powering SCE video game streaming services including Remote Play (between the PlayStation 4 and PlayStation Vita) and an upcoming cloud-based game streaming service (PlayStation Now). Gaikai is driven by a simple mission: make as many games available to as many people on as many devices as possible, easily and instantly. [Gaikai's Website](http://www.gaikai.com)

Industry:
Social & Leisure
Subindustry:
Gaming

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SB Score:108

A premier music platform for independent artists and labels to showcase, promote, and earn from their content. Boost exposure and monetize your talent in the global music community.

Industry:
Social & Leisure
Subindustry:
Entertainment

National Rank (United States)

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Total amount:2

Most Funded Startups in Aliso Viejo for 2025

The top three most funded startups in Aliso Viejo have raised total funding of more than USD 396M. Vertos Medical has 0.82% more funding than Spyglass Pharma.
SB Score:432

Vertos Medical develops and sells innovative medical devices for treating spinal conditions. Their products are designed to address common spinal diseases, providing patients with effective treatment options.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

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Regional Rank (North America)

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SB Score:373

Spyglass Pharma is dedicated to developing innovative treatments for chronic eye diseases using advanced technology. The company aims to deliver a range of drugs targeting various ophthalmic conditions, striving to improve patient outcomes and enhance vision care.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:361

Corent Technology offers SurPaaS, a platform for SaaS transformation and software delivery. Ideal for various companies, it streamlines processes and enhances efficiency.

Industry:
Software & Data
Subindustry:
Cloud

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

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Total amount:40

Top Hiring Startups in Aliso Viejo by Employee Number

The top three hiring startups in Aliso Viejo have an median employee size that is between [501-1000]
SB Score:468

Indie is a tech company at the forefront of the autotech revolution, specializing in cutting-edge automotive semiconductors and software platforms.

Industry:
Transportation
Subindustry:
Automotive

National Rank (United States)

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SB Score:236

CyberProof efficiently handles security operations, reducing response time and costs while minimizing business risk.

Industry:
Software & Data
Subindustry:
Cloud

National Rank (United States)

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SB Score:373

This innovative IT management and security solution seamlessly integrates Vulnerability Scanning, Patch Management, and EDR functionalities. Users can easily identify and address security vulnerabilities, manage patches effectively, and enhance endpoint security all in one platform.

Industry:
Software & Data
Subindustry:
Cloud

National Rank (United States)

0

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Regional Rank (North America)

0

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Global Rank (WorldWide)

0

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SB Score:432

Vertos Medical develops and sells innovative medical devices for treating spinal conditions. Their products are designed to address common spinal diseases, providing patients with effective treatment options.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (United States)

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Global Rank (WorldWide)

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Total amount:40

Explore the Startup Ecosystem of Aliso Viejo

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Top Cities for Startups in United States - Ranked by StartupBlink

StartupBlink ranks the startup ecosystems of more than 100 countries and 1,000 cities. Download our latest Global Startup Ecosystem Report.
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2024 National Rank CityGlobal Rank
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Total Score

Access subscores for 1000 cities and 100 countries

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Quantity Score
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Quality Score
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Business Score
1st
0
1st
0
710.966
00.00
00.00
00.00
2nd
0
2nd
0
251.377
00.00
00.00
00.00
3rd
0
4th
0
121.937
00.00
00.00
00.00
4th
0
5th
0
109.679
00.00
00.00
00.00
5th
0
12th
0
52.052
00.00
00.00
00.00
6th
0
15th
0
42.256
00.00
00.00
00.00
7th
+
1
17th
+
4
41.259
00.00
00.00
00.00
8th
-
1
19th
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1
37.971
00.00
00.00
00.00
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0
24th
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2
34.098
00.00
00.00
00.00
10th
0
25th
+
1
33.768
00.00
00.00
00.00
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