41 Top startups in Heidelberg for April 2025

We rank Getsafe, Aleph Alpha and Instaffo in Heidelberg along with 38 other startups based on an algorithm that scores startups based on total investment, employee count, and quarterly website traffic. Heidelberg is part of Rhine-Neckar Area startup ecosystem which ranks #152 globally and #38 in Western Europe.

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Best Startups in Heidelberg for 2025

SB Score:524

Getsafe is a modern insurance company designed for mobile users. Offering seamless digital solutions, Getsafe is perfect for today's tech-savvy individuals.

Industry:
Fintech
Subindustry:
Insurance

National Rank (Germany)

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Regional Rank (Western Europe)

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SB Score:518

Aleph Alpha transforms human-machine interactions. The company researches, develops, and operationalizes AI-based technology for the public and private sectors. Its generative AI solutions enable enterprises and governmental organizations to build intelligent products.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

National Rank (Germany)

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Regional Rank (Western Europe)

0

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SB Score:485

Instaffo revolutionizes recruiting with a fully automated platform for companies and ambitious professionals. Discover top talent and exciting career opportunities effortlessly.

Industry:
Software & Data
Subindustry:
Data Analytics

National Rank (Germany)

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Regional Rank (Western Europe)

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SB Score:384

Heidelberg Pharma GmbH, a drug development company, provides pre-clinical drug discovery and development services for the development of anti-cancer and anti-inflammatory drugs to pharmaceutical and biotechnology industries. It offers services, such as explorative pharmacology, drug metabolism and pharmacokinetics analysis, and molecular biology in the fields of oncology or inflammatory/autoimmune diseases.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (Germany)

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Regional Rank (Western Europe)

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Global Rank (WorldWide)

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Talk’n’Job is an innovative app for blue-collar workers and young professionals, providing a modern alternative to traditional job applications. Connect with employers in production, service, and logistics with ease.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (Germany)

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Regional Rank (Western Europe)

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SB Score:357

Apogenix creates innovative protein therapies for cancer and inflammatory conditions. Their biopharmaceutical products aim to revolutionize treatment options in these areas.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (Germany)

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Regional Rank (Western Europe)

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SB Score:338

Luxendo specializes in the manufacturing and sales of cutting-edge Single Plane Illumination Microscopes (SPIM), originally developed at EMBL by Lars Hufnagel and his team. These advanced microscopes enable researchers to achieve unparalleled imaging quality, enhancing their ability to explore biological processes with precision and clarity.

Industry:
Healthtech
Subindustry:
Life Sciences

National Rank (Germany)

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Regional Rank (Western Europe)

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SB Score:328

Paretos is a leading AI-driven decision intelligence platform that empowers organizations to make data-driven choices. With its no-code interface and seamless integrations, it enables business users to analyze complex data, forecast future scenarios, and execute optimal actions without requiring prior data science expertise.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

National Rank (Germany)

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Regional Rank (Western Europe)

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10th

Lora
SB Score:322

Lora specializes in aesthetic dental treatments, offering routine checkups, cleanings, implantology, orthodontics, and teeth whitening. With services like invisible tooth correction and veneers, Lora ensures a radiant smile. Convenient online booking is available for all treatments, making dental care accessible and hassle-free.

Industry:
Healthtech
Subindustry:
Health Care

National Rank (Germany)

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Regional Rank (Western Europe)

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SB Score:307

Quality Match is a premier knowledge annotation provider that delivers exceptional annotation services. By utilizing advanced techniques and skilled professionals, it enhances data quality, ensuring accurate and reliable insights for businesses seeking to optimize their machine learning and artificial intelligence projects.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

National Rank (Germany)

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Regional Rank (Western Europe)

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Total amount:41

Top 13 Software & Data Startups in Heidelberg for 2025

The top three Software & Data startups in Heidelberg have raised more than USD 764M. Heidelberg is part of Rhine-Neckar Area startup ecosystem which ranks #90 globally for the Software & Data industry.
SB Score:518

Aleph Alpha transforms human-machine interactions. The company researches, develops, and operationalizes AI-based technology for the public and private sectors. Its generative AI solutions enable enterprises and governmental organizations to build intelligent products.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

National Rank (Germany)

0

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Regional Rank (Western Europe)

0

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Global Rank (WorldWide)

0

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SB Score:485

Instaffo revolutionizes recruiting with a fully automated platform for companies and ambitious professionals. Discover top talent and exciting career opportunities effortlessly.

Industry:
Software & Data
Subindustry:
Data Analytics

National Rank (Germany)

0

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Regional Rank (Western Europe)

0

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Global Rank (WorldWide)

0

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Talk’n’Job is an innovative app for blue-collar workers and young professionals, providing a modern alternative to traditional job applications. Connect with employers in production, service, and logistics with ease.

Industry:
Software & Data
Subindustry:
Enterprise Technology

National Rank (Germany)

0

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Regional Rank (Western Europe)

0

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Global Rank (WorldWide)

0

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Total amount:13

Top 15 Healthtech Startups in Heidelberg for 2025

The top three Healthtech startups in Heidelberg have raised more than USD 131M. Heidelberg is part of Rhine-Neckar Area startup ecosystem which ranks #144 globally for the Healthtech industry.
SB Score:384

Heidelberg Pharma GmbH, a drug development company, provides pre-clinical drug discovery and development services for the development of anti-cancer and anti-inflammatory drugs to pharmaceutical and biotechnology industries. It offers services, such as explorative pharmacology, drug metabolism and pharmacokinetics analysis, and molecular biology in the fields of oncology or inflammatory/autoimmune diseases.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (Germany)

0

View

Regional Rank (Western Europe)

0

View

Global Rank (WorldWide)

0

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SB Score:357

Apogenix creates innovative protein therapies for cancer and inflammatory conditions. Their biopharmaceutical products aim to revolutionize treatment options in these areas.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (Germany)

0

View

Regional Rank (Western Europe)

0

View

Global Rank (WorldWide)

0

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SB Score:338

Luxendo specializes in the manufacturing and sales of cutting-edge Single Plane Illumination Microscopes (SPIM), originally developed at EMBL by Lars Hufnagel and his team. These advanced microscopes enable researchers to achieve unparalleled imaging quality, enhancing their ability to explore biological processes with precision and clarity.

Industry:
Healthtech
Subindustry:
Life Sciences

National Rank (Germany)

0

View

Regional Rank (Western Europe)

0

View

Global Rank (WorldWide)

0

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Total amount:15

Top 2 Fintech Startups in Heidelberg for 2025

The top three Fintech startups in Heidelberg have raised more than USD 118M. Heidelberg is part of Rhine-Neckar Area startup ecosystem which ranks #208 globally for the Fintech industry.
SB Score:524

Getsafe is a modern insurance company designed for mobile users. Offering seamless digital solutions, Getsafe is perfect for today's tech-savvy individuals.

Industry:
Fintech
Subindustry:
Insurance

National Rank (Germany)

0

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Regional Rank (Western Europe)

0

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Global Rank (WorldWide)

0

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2nd

Enzo
SB Score:285

Enzo delivers modern home insurance that matches the needs of today's customers in terms of usability and insurance coverage. We use IoT to fix one of the biggest problems of the traditional product line: tap water damage. To detect leakages early on, customers get a small sensor that sends data in real time and helps in automated processes.

Industry:
Fintech
Subindustry:
Insurance

National Rank (Germany)

0

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Regional Rank (Western Europe)

0

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Global Rank (WorldWide)

0

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Total amount:2

Most Funded Startups in Heidelberg for 2025

The top three most funded startups in Heidelberg have raised total funding of more than USD 892M. Aleph Alpha has 5.18% more funding than Getsafe.
SB Score:518

Aleph Alpha transforms human-machine interactions. The company researches, develops, and operationalizes AI-based technology for the public and private sectors. Its generative AI solutions enable enterprises and governmental organizations to build intelligent products.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

National Rank (Germany)

0

View

Regional Rank (Western Europe)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:524

Getsafe is a modern insurance company designed for mobile users. Offering seamless digital solutions, Getsafe is perfect for today's tech-savvy individuals.

Industry:
Fintech
Subindustry:
Insurance

National Rank (Germany)

0

View

Regional Rank (Western Europe)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:357

Apogenix creates innovative protein therapies for cancer and inflammatory conditions. Their biopharmaceutical products aim to revolutionize treatment options in these areas.

Industry:
Healthtech
Subindustry:
Biotechnology

National Rank (Germany)

0

View

Regional Rank (Western Europe)

0

View

Global Rank (WorldWide)

0

Browse
View full page

Total amount:41

Top Hiring Startups in Heidelberg by Employee Number

The top three hiring startups in Heidelberg have an median employee size that is between [251-500]
SB Score:338

Luxendo specializes in the manufacturing and sales of cutting-edge Single Plane Illumination Microscopes (SPIM), originally developed at EMBL by Lars Hufnagel and his team. These advanced microscopes enable researchers to achieve unparalleled imaging quality, enhancing their ability to explore biological processes with precision and clarity.

Industry:
Healthtech
Subindustry:
Life Sciences

National Rank (Germany)

0

View

Regional Rank (Western Europe)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:524

Getsafe is a modern insurance company designed for mobile users. Offering seamless digital solutions, Getsafe is perfect for today's tech-savvy individuals.

Industry:
Fintech
Subindustry:
Insurance

National Rank (Germany)

0

View

Regional Rank (Western Europe)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:518

Aleph Alpha transforms human-machine interactions. The company researches, develops, and operationalizes AI-based technology for the public and private sectors. Its generative AI solutions enable enterprises and governmental organizations to build intelligent products.

Industry:
Software & Data
Subindustry:
Artificial Intelligence

National Rank (Germany)

0

View

Regional Rank (Western Europe)

0

View

Global Rank (WorldWide)

0

Browse
View full page
SB Score:485

Instaffo revolutionizes recruiting with a fully automated platform for companies and ambitious professionals. Discover top talent and exciting career opportunities effortlessly.

Industry:
Software & Data
Subindustry:
Data Analytics

National Rank (Germany)

0

View

Regional Rank (Western Europe)

0

View

Global Rank (WorldWide)

0

Browse
View full page

Total amount:41

Explore the Startup Ecosystem of Heidelberg

National Rank

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Regional Rank

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38th

2

Global Rank

(WorldWide)

152nd

4

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Top Cities for Startups in Germany - Ranked by StartupBlink

StartupBlink ranks the startup ecosystems of more than 100 countries and 1,000 cities. Download our latest Global Startup Ecosystem Report.
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2024 National Rank CityGlobal Rank
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Total Score

Access subscores for 1000 cities and 100 countries

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Quantity Score
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Quality Score
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Business Score
1st
0
13th
-
2
49.918
00.00
00.00
00.00
2nd
0
39th
-
5
21.959
00.00
00.00
00.00
3rd
0
98th
-
8
8.060
00.00
00.00
00.00
4th
+
1
134th
+
26
5.112
00.00
00.00
00.00
5th
-
1
152nd
-
4
4.237
00.00
00.00
00.00
6th
0
154th
+
12
4.149
00.00
00.00
00.00
7th
+
1
163rd
+
25
3.886
00.00
00.00
00.00
8th
+
1
178th
+
26
3.244
00.00
00.00
00.00
9th
-
2
206th
-
24
2.481
00.00
00.00
00.00
10th
+
5
225th
+
40
2.084
00.00
00.00
00.00
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